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dc.contributor.authorMøller, Pål
dc.contributor.authorSeppälä, Toni
dc.contributor.authorDowty, James G.
dc.contributor.authorHaupt, Saskia
dc.contributor.authorDominguez-Valentin, Mev
dc.contributor.authorSunde, Lone
dc.contributor.authorBernstein, Inge
dc.contributor.authorEngel, Christoph
dc.contributor.authorAretz, Stefan
dc.contributor.authorNielsen, Maartje
dc.contributor.authorCapella, Gabriel
dc.contributor.authorEvans, Dafydd Gareth
dc.contributor.authorBurn, John
dc.contributor.authorHolinski-Feder, Elke
dc.contributor.authorBertario, Lucio
dc.contributor.authorBonanni, Bernardo
dc.contributor.authorLindblom, Annika
dc.contributor.authorLevi, Zohar
dc.contributor.authorMacrae, Finlay
dc.contributor.authorWinship, Ingrid
dc.contributor.authorPlazzer, John-Paul
dc.contributor.authorSijmons, Rolf
dc.contributor.authorLaghi, Luigi
dc.contributor.authorValle Della, Adriana
dc.contributor.authorHeinimann, Karl
dc.contributor.authorHalf, Elizabeth
dc.contributor.authorLopez-Koestner, Francisco
dc.contributor.authorAlvarez-Valenzuela, Karin
dc.contributor.authorScott, Rodney J.
dc.contributor.authorKatz, Lior
dc.contributor.authorLaish, Ido
dc.contributor.authorVainer, Elez
dc.contributor.authorVaccaro, Carlos Alberto
dc.contributor.authorCarraro, Dirce Maria
dc.contributor.authorGluck, Nathan
dc.contributor.authorAbu-Freha, Naim
dc.contributor.authorStakelum, Aine
dc.contributor.authorKennelly, Rory
dc.contributor.authorWinter, Des
dc.contributor.authorRossi, Benedito Mauro
dc.contributor.authorGreenblatt, Marc
dc.contributor.authorBohorquez, Mabel
dc.contributor.authorSheth, Harsh
dc.contributor.authorTibiletti, Maria Grazia
dc.contributor.authorLino-Silva, Leonardo S.
dc.contributor.authorHorisberger, Karoline
dc.contributor.authorPortenkirchner, Carmen
dc.contributor.authorNascimento, Ivana
dc.contributor.authorRossi, Norma Teresa
dc.contributor.authorda Silva, Leandro Apolinário
dc.contributor.authorThomas, Huw
dc.contributor.authorZaránd, Attila
dc.contributor.authorMecklin, Jukka-Pekka
dc.contributor.authorPylvänäinen, Kirsi
dc.contributor.authorRenkonen-Sinisalo, Laura
dc.contributor.authorLepistö, Anna
dc.contributor.authorPeltomäki, Päivi
dc.contributor.authorTherkildsen, Christina
dc.contributor.authorLindberg, Lars Joachim
dc.contributor.authorThorlacius-Ussing, Ole
dc.contributor.authorvon Knebel, Doeberitz Magnus
dc.contributor.authorLoeffler, Markus
dc.contributor.authorRahner, Nils
dc.contributor.authorSteinke-Lange, Verena
dc.contributor.authorSchmiegel, Wolff
dc.contributor.authorVangala, Deepak
dc.contributor.authorPerne, Claudia
dc.contributor.authorHüneburg, Robert
dc.contributor.authorde Vargas, Aída Falcón
dc.contributor.authorLatchford, Andrew
dc.contributor.authorGerdes, Anne-Marie
dc.contributor.authorBackman, Ann-Sofie
dc.contributor.authorGuillén-Ponce, Carmen
dc.contributor.authorSnyder, Carrie
dc.contributor.authorLautrup, Charlotte K.
dc.contributor.authorAmor, David
dc.contributor.authorPalmero, Edenir
dc.contributor.authorStoffel, Elena
dc.contributor.authorDuijkers, Floor
dc.contributor.authorHall, Michael J.
dc.contributor.authorHampel, Heather
dc.contributor.authorWilliams, Heinric
dc.contributor.authorOkkels, Henrik
dc.contributor.authorLubiński, Jan
dc.contributor.authorReece, Jeanette
dc.contributor.authorNgeow, Joanne
dc.contributor.authorGuillem, Jose G.
dc.contributor.authorArnold, Julie
dc.contributor.authorWadt, Karin
dc.contributor.authorMonahan, Kevin
dc.contributor.authorSenter, Leigha
dc.contributor.authorRasmussen, Lene J.
dc.contributor.authorvan Hest, Liselotte P.
dc.contributor.authorRicciardiello, Luigi
dc.contributor.authorKohonen-Corish, Maija R. J.
dc.contributor.authorLigtenberg, Marjolijn J. L.
dc.contributor.authorSouthey, Melissa
dc.contributor.authorAronson, Melyssa
dc.contributor.authorZahary, Mohd N.
dc.contributor.authorSamadder, N. Jewel
dc.contributor.authorPoplawski, Nicola
dc.contributor.authorHoogerbrugge, Nicoline
dc.contributor.authorMorrison, Patrick J.
dc.contributor.authorJames, Paul
dc.contributor.authorLee, Grant
dc.contributor.authorChen-Shtoyerman, Rakefet
dc.contributor.authorAnkathil, Ravindran
dc.contributor.authorPai, Rish
dc.contributor.authorWard, Robyn
dc.contributor.authorParry, Susan
dc.contributor.authorDębniak, Tadeusz
dc.contributor.authorJohn, Thomas
dc.contributor.authorvan Overeem, Hansen Thomas
dc.contributor.authorCaldés, Trinidad
dc.contributor.authorYamaguchi, Tatsuro
dc.contributor.authorBarca-Tierno, Verónica
dc.contributor.authorGarre, Pilar
dc.contributor.authorCavestro, Giulia Martina
dc.contributor.authorWeitz, Jürgen
dc.contributor.authorRedler, Silke
dc.contributor.authorBüttner, Reinhard
dc.contributor.authorHeuveline, Vincent
dc.contributor.authorHopper, John L.
dc.contributor.authorWin, Aung Ko
dc.contributor.authorLindor, Noralane
dc.contributor.authorGallinger, Steven
dc.contributor.authorLe Marchand, Loïc
dc.contributor.authorNewcomb, Polly A.
dc.contributor.authorFigueiredo, Jane
dc.contributor.authorBuchanan, Daniel D.
dc.contributor.authorThibodeau, Stephen N.
dc.contributor.authorten Broeke, Sanne W.
dc.contributor.authorHovig, Eivind
dc.contributor.authorNakken, Sigve
dc.contributor.authorPineda, Marta
dc.contributor.authorDueñas, Nuria
dc.contributor.authorBrunet, Joan
dc.contributor.authorGreen, Kate
dc.contributor.authorLalloo, Fiona
dc.contributor.authorNewton, Katie
dc.contributor.authorCrosbie, Emma J.
dc.contributor.authorMints, Miriam
dc.contributor.authorTjandra, Douglas
dc.contributor.authorNeffa, Florencia
dc.contributor.authorEsperon, Patricia
dc.contributor.authorKariv, Revital
dc.contributor.authorRosner, Guy
dc.contributor.authorPavicic, Walter Hernán
dc.contributor.authorKalfayan, Pablo
dc.contributor.authorTorrezan, Giovana Tardin
dc.contributor.authorBassaneze, Thiago
dc.contributor.authorMartin, Claudia
dc.contributor.authorMoslein, Gabriela
dc.contributor.authorAhadova, Aysel
dc.contributor.authorKloor, Matthias
dc.contributor.authorSampson, Julian R.
dc.contributor.authorJenkins, Mark A.
dc.contributor.authorThe European Hereditary Tumour Group (EHTG)
dc.contributor.authorthe International Mismatch Repair Consortium (IMRC)
dc.date.accessioned2022-10-04T06:17:38Z
dc.date.available2022-10-04T06:17:38Z
dc.date.issued2022
dc.identifier.citationMøller, Pål, Seppälä, Toni, Dowty, James G., Haupt, Saskia, Dominguez-Valentin, Mev, Sunde, Lone, Bernstein, Inge, Engel, Christoph, Aretz, Stefan, Nielsen, Maartje, Capella, Gabriel, Evans, Dafydd Gareth, Burn, John, Holinski-Feder, Elke, Bertario, Lucio, Bonanni, Bernardo, Lindblom, Annika, Levi, Zohar, Macrae, Finlay, Winship, Ingrid, Plazzer, John-Paul, Sijmons, Rolf, Laghi, Luigi, Valle Della, Adriana, Heinimann, Karl, Half, Elizabeth, Lopez-Koestner, Francisco, Alvarez-Valenzuela, Karin, Scott, Rodney J., Katz, Lior, Laish, Ido, Vainer, Elez, Vaccaro, Carlos Alberto, Carraro, Dirce Maria, Gluck, Nathan, Abu-Freha, Naim, Stakelum, Aine, Kennelly, Rory, Winter, Des, Rossi, Benedito Mauro, Greenblatt, Marc, Bohorquez, Mabel, Sheth, Harsh, Tibiletti, Maria Grazia, Lino-Silva, Leonardo S., Horisberger, Karoline, Portenkirchner, Carmen, Nascimento, Ivana, Rossi, Norma Teresa, da Silva, Leandro Apolinário, Thomas, Huw, Zaránd, Attila, Mecklin, Jukka-Pekka, Pylvänäinen, Kirsi, Renkonen-Sinisalo, Laura, Lepistö, Anna, Peltomäki, Päivi, Therkildsen, Christina, Lindberg, Lars Joachim, Thorlacius-Ussing, Ole, von Knebel, Doeberitz Magnus, Loeffler, Markus, Rahner, Nils, Steinke-Lange, Verena, Schmiegel, Wolff, Vangala, Deepak, Perne, Claudia, Hüneburg, Robert, de Vargas, Aída Falcón, Latchford, Andrew, Gerdes, Anne-Marie, Backman, Ann-Sofie, Guillén-Ponce, Carmen, Snyder, Carrie, Lautrup, Charlotte K., Amor, David, Palmero, Edenir, Stoffel, Elena, Duijkers, Floor, Hall, Michael J., Hampel, Heather, Williams, Heinric, Okkels, Henrik, Lubiński, Jan, Reece, Jeanette, Ngeow, Joanne, Guillem, Jose G., Arnold, Julie, Wadt, Karin, Monahan, Kevin, Senter, Leigha, Rasmussen, Lene J., van Hest, Liselotte P., Ricciardiello, Luigi, Kohonen-Corish, Maija R. J., Ligtenberg, Marjolijn J. L., Southey, Melissa, Aronson, Melyssa, Zahary, Mohd N., Samadder, N. Jewel, Poplawski, Nicola, Hoogerbrugge, Nicoline, Morrison, Patrick J., James, Paul, Lee, Grant, Chen-Shtoyerman, Rakefet, Ankathil, Ravindran, Pai, Rish, Ward, Robyn, Parry, Susan, Dębniak, Tadeusz, John, Thomas, van Overeem, Hansen Thomas, Caldés, Trinidad, Yamaguchi, Tatsuro, Barca-Tierno, Verónica, Garre, Pilar, Cavestro, Giulia Martina, Weitz, Jürgen, Redler, Silke, Büttner, Reinhard, Heuveline, Vincent, Hopper, John L., Win, Aung Ko, Lindor, Noralane, Gallinger, Steven, Le Marchand, Loïc, Newcomb, Polly A., Figueiredo, Jane, Buchanan, Daniel D., Thibodeau, Stephen N., ten Broeke, Sanne W., Hovig, Eivind, Nakken, Sigve, Pineda, Marta, Dueñas, Nuria, Brunet, Joan, Green, Kate, Lalloo, Fiona, Newton, Katie, Crosbie, Emma J., Mints, Miriam, Tjandra, Douglas, Neffa, Florencia, Esperon, Patricia, Kariv, Revital, Rosner, Guy, Pavicic, Walter Hernán, Kalfayan, Pablo, Torrezan, Giovana Tardin, Bassaneze, Thiago, Martin, Claudia, Moslein, Gabriela, Ahadova, Aysel, Kloor, Matthias, Sampson, Julian R., Jenkins, Mark A., The European Hereditary Tumour Group (EHTG), the International Mismatch Repair Consortium (IMRC). (2022). Colorectal cancer incidences in Lynch syndrome : a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium. <i>Hereditary cancer in clinical practice</i>, <i>20</i>, Article 36. <a href="https://doi.org/10.1186/s13053-022-00241-1" target="_blank">https://doi.org/10.1186/s13053-022-00241-1</a>
dc.identifier.otherCONVID_156898767
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/83432
dc.description.abstractObjective: To compare colorectal cancer (CRC) incidences in carriers of pathogenic variants of the MMR genes in the PLSD and IMRC cohorts, of which only the former included mandatory colonoscopy surveillance for all participants. Methods: CRC incidences were calculated in an intervention group comprising a cohort of confirmed carriers of pathogenic or likely pathogenic variants in mismatch repair genes (path_MMR) followed prospectively by the Prospective Lynch Syndrome Database (PLSD). All had colonoscopy surveillance, with polypectomy when polyps were identified. Comparison was made with a retrospective cohort reported by the International Mismatch Repair Consortium (IMRC). This comprised confirmed and inferred path_MMR carriers who were first- or second-degree relatives of Lynch syndrome probands. Results: In the PLSD, 8,153 subjects had follow-up colonoscopy surveillance for a total of 67,604 years and 578 carriers had CRC diagnosed. Average cumulative incidences of CRC in path_MLH1 carriers at 70 years of age were 52% in males and 41% in females; for path_MSH2 50% and 39%; for path_MSH6 13% and 17% and for path_PMS2 11% and 8%. In contrast, in the IMRC cohort, corresponding cumulative incidences were 40% and 27%; 34% and 23%; 16% and 8% and 7% and 6%. Comparing just the European carriers in the two series gave similar findings. Numbers in the PLSD series did not allow comparisons of carriers from other continents separately. Cumulative incidences at 25 years were < 1% in all retrospective groups. Conclusions: Prospectively observed CRC incidences (PLSD) in path_MLH1 and path_MSH2 carriers undergoing colonoscopy surveillance and polypectomy were higher than in the retrospective (IMRC) series, and were not reduced in path_MSH6 carriers. These findings were the opposite to those expected. CRC point incidence before 50 years of age was reduced in path_PMS2 carriers subjected to colonoscopy, but not significantly so.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherBiomed Central
dc.relation.ispartofseriesHereditary cancer in clinical practice
dc.rightsCC BY 4.0
dc.subject.otherLynch syndrome
dc.subject.otherepidemiology
dc.subject.otherprevention
dc.subject.otherpenetrance
dc.subject.othercolorectal cancer
dc.subject.othersegregation analysis
dc.subject.otherprospective
dc.subject.otherincidence
dc.subject.otherover-diagnosis
dc.subject.othercolonoscopy
dc.titleColorectal cancer incidences in Lynch syndrome : a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202210044776
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn1731-2302
dc.relation.volume20
dc.type.versionpublishedVersion
dc.rights.copyright© The Author(s) 2022
dc.rights.accesslevelopenAccessfi
dc.subject.ysosegregaatio
dc.subject.ysoläpäisevyys
dc.subject.ysoilmaantuvuus
dc.subject.ysoLynchin oireyhtymä
dc.subject.ysoehkäisy
dc.subject.ysosuolistosyövät
dc.subject.ysoepidemiologia
dc.subject.ysokoloskopia
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p20563
jyx.subject.urihttp://www.yso.fi/onto/yso/p19404
jyx.subject.urihttp://www.yso.fi/onto/yso/p25910
jyx.subject.urihttp://www.yso.fi/onto/yso/p23697
jyx.subject.urihttp://www.yso.fi/onto/yso/p793
jyx.subject.urihttp://www.yso.fi/onto/yso/p25845
jyx.subject.urihttp://www.yso.fi/onto/yso/p11307
jyx.subject.urihttp://www.yso.fi/onto/yso/p1078
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1186/s13053-022-00241-1
jyx.fundinginformationToni T. Seppälä: Finnish Medical Foundation, Emil Aaltonen Foundation, Cancer Society Finland, Jane and Aatos Erkko Foundation, iCAN Digital Precision Cancer Medicine Flagship, Relander Foundation, Sigrid Juselius Foundation, and Academy of Finland. Jukka-Pekka Mecklin: Cancer Society Finland, Jane and Aatos Erkko Foundation. G Capellá team: funded by the Spanish Ministry of Economy and Competitiveness and co-funded by FEDER funds -a way to build Europe- (grant PID2019-111254RB-I00) and CIBERONC (CB16/12/00234). We thank CERCA Program / Generalitat de Catalunya for institutional support. S Aretz , E Holinski-Feder, and V Steinke-Lange were sup ported by the European Reference Network on Genetic Tumor Risk Syndromes (ERN GENTURIS) – Project ID No 739547. ERN GENTURIS is partly co-funded by the European Union within the framework of the Third Health Programme “ERN-2016 – Framework Partnership Agreement 2017–2021”. BMRossi team: we thank LA-GETH (Latin America - Grupo de Estudios de Tumores Heredi tarios) for the Institutional support. DGE and EJC are supported by the all Manchester NIHR Biomedical Research Centre (IS-BRC-1215-20007). JRS thanks HCRW for its support via Wales Gene Park. MRJ Kohonen-Corish had a grant from Cancer Council NSW grant RG19-01. J Burn contributed with support from Cancer Research U.K. catalyst award: Aspirin for Cancer Prevention AsCaP CRUK A24991. ”. The German Consortium for Familial Intestinal Cancer was supported by grants of the German Cancer Aid. DM Carraro and GT Torrezan: Funded by the National Institute of Science and Technology in Oncogenom ics and Therapeutic Innovation (FAPESP 2014/509443-1, CNPq 465682/2014-6 and CAPES - 88887.136405/2017-00). ). We acknowledge funding from the Norwegian Cancer Society, contract 194751-2017.
dc.type.okmA1


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