Show simple item record

dc.contributor.authorStraminelli, Leonardo
dc.contributor.authorVicentini, Francesco
dc.contributor.authorDi Sabato, Antonio
dc.contributor.authorMontone, Carmela Maria
dc.contributor.authorCavaliere, Chiara
dc.contributor.authorRissanen, Kari
dc.contributor.authorLeonelli, Francesca
dc.contributor.authorVetica, Fabrizio
dc.date.accessioned2022-08-22T09:59:57Z
dc.date.available2022-08-22T09:59:57Z
dc.date.issued2022
dc.identifier.citationStraminelli, L., Vicentini, F., Di Sabato, A., Montone, C. M., Cavaliere, C., Rissanen, K., Leonelli, F., & Vetica, F. (2022). Stereoselective Synthesis of Spiro-Decalin Oxindole Derivatives via Sequential Organocatalytic Michael-Domino Michael/Aldol Reaction. <i>Journal of Organic Chemistry</i>, <i>87</i>(15), 10454-10461. <a href="https://doi.org/10.1021/acs.joc.2c01046" target="_blank">https://doi.org/10.1021/acs.joc.2c01046</a>
dc.identifier.otherCONVID_150935357
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/82754
dc.description.abstractA highly stereoselective procedure for the synthesis of spiro-polycyclic oxindoles bearing five contiguous stereogenic centers including two tetrasubstituted carbons has been developed. Under sequential organocatalysis performed by a pyrrolidine-based organocatalyst and DBU, a highly atom-economical Michael–domino Michael/aldol reaction sequence was optimized, yielding variously functionalized spiro-decalin oxindoles with excellent stereoselectivity (>99:1 dr, up to 92% ee).en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherAmerican Chemical Society (ACS)
dc.relation.ispartofseriesJournal of Organic Chemistry
dc.rightsCC BY 4.0
dc.titleStereoselective Synthesis of Spiro-Decalin Oxindole Derivatives via Sequential Organocatalytic Michael-Domino Michael/Aldol Reaction
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202208224292
dc.contributor.laitosKemian laitosfi
dc.contributor.laitosDepartment of Chemistryen
dc.contributor.oppiaineOrgaaninen kemiafi
dc.contributor.oppiaineOrganic Chemistryen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange10454-10461
dc.relation.issn0022-3263
dc.relation.numberinseries15
dc.relation.volume87
dc.type.versionpublishedVersion
dc.rights.copyright© 2022 The Authors. Published by American Chemical Society
dc.rights.accesslevelopenAccessfi
dc.subject.ysokemiallinen synteesi
dc.subject.ysoorgaaninen kemia
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p8468
jyx.subject.urihttp://www.yso.fi/onto/yso/p11902
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1021/acs.joc.2c01046
jyx.fundinginformationThe authors gratefully thank the colleagues at Sapienza University of Rome (Prof. Patrizia Gentili, Prof. Marta Feroci, Prof. Marco Bella), Dr. Giuliana Righi, and the Institute of Biological Systems (ISB) of the Italian National Research Council (CNR) for the donation of chemicals. Financial support from Sapienza University of Rome (Grant Number RP12117A5C0CA0CC) is gratefully acknowledged.
dc.type.okmA1


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

CC BY 4.0
Except where otherwise noted, this item's license is described as CC BY 4.0