Schizophrenia polygenic risk score and long-term success in the labour market : A cohort study
Viinikainen, J., Böckerman, P., Hakulinen, C., Kari, J., Lehtimäki, T., Raitakari, O., & Pehkonen, J. (2022). Schizophrenia polygenic risk score and long-term success in the labour market : A cohort study. Journal of Psychiatric Research, 151, 638-641. https://doi.org/10.1016/j.jpsychires.2022.05.041
Published inJournal of Psychiatric Research
DisciplinePäätöksentekoa tukeva taloustiede ja talouden kilpailukyky (painoala)TaloustiedeEmpirical MicroeconomicsBasic or discovery scholarshipPolicy-Relevant Economics and Competitiveness of Economy (focus area)EconomicsEmpirical MicroeconomicsBasic or discovery scholarship
© 2022 the Authors
Employment is rare among people with a schizophrenia diagnosis. Meanwhile, a genetic liability for schizophrenia may hinder labour market performance. We studied how the polygenic risk score (PGS) for schizophrenia related to education and labour market outcomes. We found that a higher PGS was linked to lower educational levels and weaker labour market outcomes as well as a higher likelihood of receiving social income transfers, particularly among men. Assuming that the link is causal, our results indicate that individuals with schizophrenia or schizophrenia-related traits have a weakened ability to fully participate in the labour market, potentially reinforcing social exclusion.
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- Kauppakorkeakoulu 
Additional information about fundingThe Young Finns Study has been financially supported by the Academy of Finland: grants 322098, 286284, 134309 (Eye), 126925, 121584, 124282, 255381, 256474, 283115, 319060, 320297, 314389, 338395, 330809, and 104821, 129378 (Salve), 117797 (Gendi), and 141071 (Skidi); the Social Insurance Institution of Finland; Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals (grant X51001); Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation for Cardiovascular Research; Finnish Cultural Foundation; The Sigrid Juselius Foundation; Tampere Tuberculosis Foundation; Emil Aaltonen Foundation; Yrj ̈o Jahnsson Foundation; Signe and Ane Gyllenberg Foundation; Diabetes Research Foundation of Finnish Diabetes Association; EU Horizon 2020 (grant 755320 for TAXINOMISIS and grant 848146 for To Aition); European Research Council (grant 742927 for MULTIEPIGEN project); Tampere University Hospital Supporting Foundation, Finnish Society of Clinical Chemistry and the Cancer Foundation Finland. The use of the YFS-FLEED-LPC data has been supported by OP Group Research Foundation and Palkansaajas ̈a ̈ati ̈o. ...
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