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Schizophrenia polygenic risk score and long-term success in the labour market : A cohort study

dc.contributor.authorViinikainen, Jutta
dc.contributor.authorBöckerman, Petri
dc.contributor.authorHakulinen, Christian
dc.contributor.authorKari, Jaana, T.
dc.contributor.authorLehtimäki, Terho
dc.contributor.authorRaitakari, Olli, T.
dc.contributor.authorPehkonen, Jaakko
dc.date.accessioned2022-07-06T06:59:31Z
dc.date.available2022-07-06T06:59:31Z
dc.date.issued2022
dc.identifier.citationViinikainen, J., Böckerman, P., Hakulinen, C., Kari, J., Lehtimäki, T., Raitakari, O., & Pehkonen, J. (2022). Schizophrenia polygenic risk score and long-term success in the labour market : A cohort study. <i>Journal of Psychiatric Research</i>, <i>151</i>, 638-641. <a href="https://doi.org/10.1016/j.jpsychires.2022.05.041" target="_blank">https://doi.org/10.1016/j.jpsychires.2022.05.041</a>
dc.identifier.otherCONVID_147250450
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/82236
dc.description.abstractEmployment is rare among people with a schizophrenia diagnosis. Meanwhile, a genetic liability for schizophrenia may hinder labour market performance. We studied how the polygenic risk score (PGS) for schizophrenia related to education and labour market outcomes. We found that a higher PGS was linked to lower educational levels and weaker labour market outcomes as well as a higher likelihood of receiving social income transfers, particularly among men. Assuming that the link is causal, our results indicate that individuals with schizophrenia or schizophrenia-related traits have a weakened ability to fully participate in the labour market, potentially reinforcing social exclusion.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofseriesJournal of Psychiatric Research
dc.rightsCC BY 4.0
dc.subject.otherPolygenic risk score
dc.subject.otherEducation
dc.subject.otherEarnings
dc.subject.otherSocial income transfers
dc.titleSchizophrenia polygenic risk score and long-term success in the labour market : A cohort study
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202207063835
dc.contributor.laitosKauppakorkeakoulufi
dc.contributor.laitosSchool of Business and Economicsen
dc.contributor.oppiainePäätöksentekoa tukeva taloustiede ja talouden kilpailukyky (painoala)fi
dc.contributor.oppiaineTaloustiedefi
dc.contributor.oppiaineEmpirical Microeconomicsfi
dc.contributor.oppiaineBasic or discovery scholarshipfi
dc.contributor.oppiainePolicy-Relevant Economics and Competitiveness of Economy (focus area)en
dc.contributor.oppiaineEconomicsen
dc.contributor.oppiaineEmpirical Microeconomicsen
dc.contributor.oppiaineBasic or discovery scholarshipen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange638-641
dc.relation.issn0022-3956
dc.relation.volume151
dc.type.versionpublishedVersion
dc.rights.copyright© 2022 the Authors
dc.rights.accesslevelopenAccessfi
dc.subject.ysokoulutustaso
dc.subject.ysoperinnöllinen alttius
dc.subject.ysoperinnölliset taudit
dc.subject.ysotyöllistyminen
dc.subject.ysotyömarkkina-asema
dc.subject.ysoskitsofrenia
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p12157
jyx.subject.urihttp://www.yso.fi/onto/yso/p24980
jyx.subject.urihttp://www.yso.fi/onto/yso/p19997
jyx.subject.urihttp://www.yso.fi/onto/yso/p3542
jyx.subject.urihttp://www.yso.fi/onto/yso/p23554
jyx.subject.urihttp://www.yso.fi/onto/yso/p9659
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1016/j.jpsychires.2022.05.041
jyx.fundinginformationThe Young Finns Study has been financially supported by the Academy of Finland: grants 322098, 286284, 134309 (Eye), 126925, 121584, 124282, 255381, 256474, 283115, 319060, 320297, 314389, 338395, 330809, and 104821, 129378 (Salve), 117797 (Gendi), and 141071 (Skidi); the Social Insurance Institution of Finland; Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals (grant X51001); Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation for Cardiovascular Research; Finnish Cultural Foundation; The Sigrid Juselius Foundation; Tampere Tuberculosis Foundation; Emil Aaltonen Foundation; Yrj ̈o Jahnsson Foundation; Signe and Ane Gyllenberg Foundation; Diabetes Research Foundation of Finnish Diabetes Association; EU Horizon 2020 (grant 755320 for TAXINOMISIS and grant 848146 for To Aition); European Research Council (grant 742927 for MULTIEPIGEN project); Tampere University Hospital Supporting Foundation, Finnish Society of Clinical Chemistry and the Cancer Foundation Finland. The use of the YFS-FLEED-LPC data has been supported by OP Group Research Foundation and Palkansaajas ̈a ̈ati ̈o.
dc.type.okmA1


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