Schizophrenia polygenic risk score and long-term success in the labour market : A cohort study
Abstract
Employment is rare among people with a schizophrenia diagnosis. Meanwhile, a genetic liability for schizophrenia may hinder labour market performance. We studied how the polygenic risk score (PGS) for schizophrenia related to education and labour market outcomes. We found that a higher PGS was linked to lower educational levels and weaker labour market outcomes as well as a higher likelihood of receiving social income transfers, particularly among men. Assuming that the link is causal, our results indicate that individuals with schizophrenia or schizophrenia-related traits have a weakened ability to fully participate in the labour market, potentially reinforcing social exclusion.
Main Authors
Format
Articles
Research article
Published
2022
Series
Subjects
Publication in research information system
Publisher
Elsevier
The permanent address of the publication
https://urn.fi/URN:NBN:fi:jyu-202207063835Käytä tätä linkitykseen.
Review status
Peer reviewed
ISSN
0022-3956
DOI
https://doi.org/10.1016/j.jpsychires.2022.05.041
Language
English
Published in
Journal of Psychiatric Research
Citation
- Viinikainen, J., Böckerman, P., Hakulinen, C., Kari, J., Lehtimäki, T., Raitakari, O., & Pehkonen, J. (2022). Schizophrenia polygenic risk score and long-term success in the labour market : A cohort study. Journal of Psychiatric Research, 151, 638-641. https://doi.org/10.1016/j.jpsychires.2022.05.041
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Additional information about funding
The Young Finns Study has been financially supported by the Academy of Finland: grants 322098, 286284, 134309 (Eye), 126925, 121584, 124282, 255381, 256474, 283115, 319060, 320297, 314389, 338395, 330809, and 104821, 129378 (Salve), 117797 (Gendi), and 141071 (Skidi); the Social Insurance Institution of Finland; Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals (grant X51001); Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation for Cardiovascular Research; Finnish Cultural Foundation; The Sigrid Juselius Foundation; Tampere Tuberculosis Foundation; Emil Aaltonen Foundation; Yrj ̈o Jahnsson Foundation; Signe and Ane Gyllenberg Foundation; Diabetes Research Foundation of Finnish Diabetes Association; EU Horizon 2020 (grant 755320 for TAXINOMISIS and grant 848146 for To Aition); European Research Council (grant 742927 for MULTIEPIGEN project); Tampere University Hospital Supporting Foundation, Finnish Society of Clinical Chemistry and the Cancer Foundation Finland. The use of the YFS-FLEED-LPC data has been supported by OP Group Research Foundation and Palkansaajas ̈a ̈ati ̈o.
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