Schizophrenia polygenic risk score and long-term success in the labour market : A cohort study
| dc.contributor.author | Viinikainen, Jutta | |
| dc.contributor.author | Böckerman, Petri | |
| dc.contributor.author | Hakulinen, Christian | |
| dc.contributor.author | Kari, Jaana, T. | |
| dc.contributor.author | Lehtimäki, Terho | |
| dc.contributor.author | Raitakari, Olli, T. | |
| dc.contributor.author | Pehkonen, Jaakko | |
| dc.date.accessioned | 2022-07-06T06:59:31Z | |
| dc.date.available | 2022-07-06T06:59:31Z | |
| dc.date.issued | 2022 | |
| dc.identifier.citation | Viinikainen, J., Böckerman, P., Hakulinen, C., Kari, J., Lehtimäki, T., Raitakari, O., & Pehkonen, J. (2022). Schizophrenia polygenic risk score and long-term success in the labour market : A cohort study. <i>Journal of Psychiatric Research</i>, <i>151</i>, 638-641. <a href="https://doi.org/10.1016/j.jpsychires.2022.05.041" target="_blank">https://doi.org/10.1016/j.jpsychires.2022.05.041</a> | |
| dc.identifier.other | CONVID_147250450 | |
| dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/82236 | |
| dc.description.abstract | Employment is rare among people with a schizophrenia diagnosis. Meanwhile, a genetic liability for schizophrenia may hinder labour market performance. We studied how the polygenic risk score (PGS) for schizophrenia related to education and labour market outcomes. We found that a higher PGS was linked to lower educational levels and weaker labour market outcomes as well as a higher likelihood of receiving social income transfers, particularly among men. Assuming that the link is causal, our results indicate that individuals with schizophrenia or schizophrenia-related traits have a weakened ability to fully participate in the labour market, potentially reinforcing social exclusion. | en |
| dc.format.mimetype | application/pdf | |
| dc.language.iso | eng | |
| dc.publisher | Elsevier | |
| dc.relation.ispartofseries | Journal of Psychiatric Research | |
| dc.rights | CC BY 4.0 | |
| dc.subject.other | Polygenic risk score | |
| dc.subject.other | Education | |
| dc.subject.other | Earnings | |
| dc.subject.other | Social income transfers | |
| dc.title | Schizophrenia polygenic risk score and long-term success in the labour market : A cohort study | |
| dc.type | article | |
| dc.identifier.urn | URN:NBN:fi:jyu-202207063835 | |
| dc.contributor.laitos | Kauppakorkeakoulu | fi |
| dc.contributor.laitos | School of Business and Economics | en |
| dc.contributor.oppiaine | Päätöksentekoa tukeva taloustiede ja talouden kilpailukyky (painoala) | fi |
| dc.contributor.oppiaine | Taloustiede | fi |
| dc.contributor.oppiaine | Empirical Microeconomics | fi |
| dc.contributor.oppiaine | Basic or discovery scholarship | fi |
| dc.contributor.oppiaine | Policy-Relevant Economics and Competitiveness of Economy (focus area) | en |
| dc.contributor.oppiaine | Economics | en |
| dc.contributor.oppiaine | Empirical Microeconomics | en |
| dc.contributor.oppiaine | Basic or discovery scholarship | en |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
| dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
| dc.description.reviewstatus | peerReviewed | |
| dc.format.pagerange | 638-641 | |
| dc.relation.issn | 0022-3956 | |
| dc.relation.volume | 151 | |
| dc.type.version | publishedVersion | |
| dc.rights.copyright | © 2022 the Authors | |
| dc.rights.accesslevel | openAccess | fi |
| dc.subject.yso | koulutustaso | |
| dc.subject.yso | perinnöllinen alttius | |
| dc.subject.yso | perinnölliset taudit | |
| dc.subject.yso | työllistyminen | |
| dc.subject.yso | työmarkkina-asema | |
| dc.subject.yso | skitsofrenia | |
| dc.format.content | fulltext | |
| jyx.subject.uri | http://www.yso.fi/onto/yso/p12157 | |
| jyx.subject.uri | http://www.yso.fi/onto/yso/p24980 | |
| jyx.subject.uri | http://www.yso.fi/onto/yso/p19997 | |
| jyx.subject.uri | http://www.yso.fi/onto/yso/p3542 | |
| jyx.subject.uri | http://www.yso.fi/onto/yso/p23554 | |
| jyx.subject.uri | http://www.yso.fi/onto/yso/p9659 | |
| dc.rights.url | https://creativecommons.org/licenses/by/4.0/ | |
| dc.relation.doi | 10.1016/j.jpsychires.2022.05.041 | |
| jyx.fundinginformation | The Young Finns Study has been financially supported by the Academy of Finland: grants 322098, 286284, 134309 (Eye), 126925, 121584, 124282, 255381, 256474, 283115, 319060, 320297, 314389, 338395, 330809, and 104821, 129378 (Salve), 117797 (Gendi), and 141071 (Skidi); the Social Insurance Institution of Finland; Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals (grant X51001); Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation for Cardiovascular Research; Finnish Cultural Foundation; The Sigrid Juselius Foundation; Tampere Tuberculosis Foundation; Emil Aaltonen Foundation; Yrj ̈o Jahnsson Foundation; Signe and Ane Gyllenberg Foundation; Diabetes Research Foundation of Finnish Diabetes Association; EU Horizon 2020 (grant 755320 for TAXINOMISIS and grant 848146 for To Aition); European Research Council (grant 742927 for MULTIEPIGEN project); Tampere University Hospital Supporting Foundation, Finnish Society of Clinical Chemistry and the Cancer Foundation Finland. The use of the YFS-FLEED-LPC data has been supported by OP Group Research Foundation and Palkansaajas ̈a ̈ati ̈o. | |
| dc.type.okm | A1 |
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