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dc.contributor.authorIso-Markku, Paula
dc.contributor.authorKujala, Urho M
dc.contributor.authorKnittle, Keegan
dc.contributor.authorPolet, Juho
dc.contributor.authorVuoksimaa, Eero
dc.contributor.authorWaller, Katja
dc.date.accessioned2022-03-21T09:33:07Z
dc.date.available2022-03-21T09:33:07Z
dc.date.issued2022
dc.identifier.citationIso-Markku, P., Kujala, U. M., Knittle, K., Polet, J., Vuoksimaa, E., & Waller, K. (2022). Physical activity as a protective factor for dementia and Alzheimer’s disease : systematic review, meta-analysis and quality assessment of cohort and case-control studies. <i>British Journal of Sports Medicine</i>, <i>56</i>(12), 701-709. <a href="https://doi.org/10.1136/bjsports-2021-104981" target="_blank">https://doi.org/10.1136/bjsports-2021-104981</a>
dc.identifier.otherCONVID_104677633
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/80258
dc.description.abstractOBJECTIVE - Physical activity (PA) is associated with a decreased incidence of dementia, but much of the evidence comes from short follow-ups prone to reverse causation. This meta-analysis investigates the effect of study length on the association. -- DESIGN - A systematic review and meta-analysis. Pooled effect sizes, dose–response analysis and funnel plots were used to synthesise the results. -- DATA SOURCES - CINAHL (last search 19 October 2021), PsycInfo, Scopus, PubMed, Web of Science (21 October 2021) and SPORTDiscus (26 October 2021). -- ELIGIBILITY CRITERIA - Studies of adults with a prospective follow-up of at least 1 year, a valid cognitive measure or cohort in mid-life at baseline and an estimate of the association between baseline PA and follow-up all-cause dementia, Alzheimer’s disease or vascular dementia were included (n=58). -- RESULTS - PA was associated with a decreased risk of all-cause dementia (pooled relative risk 0.80, 95% CI 0.77 to 0.84, n=257 983), Alzheimer’s disease (0.86, 95% CI 0.80 to 0.93, n=128 261) and vascular dementia (0.79, 95% CI 0.66 to 0.95, n=33 870), even in longer follow-ups (≥20 years) for all-cause dementia and Alzheimer’s disease. Neither baseline age, follow-up length nor study quality significantly moderated the associations. Dose–response meta-analyses revealed significant linear, spline and quadratic trends within estimates for all-cause dementia incidence, but only a significant spline trend for Alzheimer’s disease. Funnel plots showed possible publication bias for all-cause dementia and Alzheimer’s disease. -- CONCLUSION - PA was associated with lower incidence of all-cause dementia and Alzheimer’s disease, even in longer follow-ups, supporting PA as a modifiable protective lifestyle factor, even after reducing the effects of reverse causation.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherBMJ Publishing Group
dc.relation.ispartofseriesBritish Journal of Sports Medicine
dc.relation.urihttp://dx.doi.org/10.1136/bjsports-2021-104981
dc.rightsCC BY 4.0
dc.subject.otherphysical activity
dc.subject.otherprotective factor
dc.subject.otherdementia
dc.subject.otherAlzheimer’s disease
dc.titlePhysical activity as a protective factor for dementia and Alzheimer’s disease : systematic review, meta-analysis and quality assessment of cohort and case-control studies
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202203211953
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiaineLiikuntapsykologiafi
dc.contributor.oppiaineSports and Exercise Medicineen
dc.contributor.oppiaineSport and Exercise Psychologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.format.pagerange701-709
dc.relation.issn0306-3674
dc.relation.numberinseries12
dc.relation.volume56
dc.type.versionpublishedVersion
dc.rights.copyright© Authors 2022
dc.rights.accesslevelopenAccessfi
dc.subject.ysofyysinen aktiivisuus
dc.subject.ysoennaltaehkäisy
dc.subject.ysoAlzheimerin tauti
dc.subject.ysodementia
dc.subject.ysosystemaattiset kirjallisuuskatsaukset
dc.subject.ysometa-analyysi
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p23102
jyx.subject.urihttp://www.yso.fi/onto/yso/p19552
jyx.subject.urihttp://www.yso.fi/onto/yso/p8412
jyx.subject.urihttp://www.yso.fi/onto/yso/p1711
jyx.subject.urihttp://www.yso.fi/onto/yso/p29683
jyx.subject.urihttp://www.yso.fi/onto/yso/p27697
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1136/bjsports-2021-104981
jyx.fundinginformationThis study was funded by Juho Vainio Foundation, HUS Diagnostic Center research funding and the Academy of Finland (grants 314639 and 320109 to EV).


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