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dc.contributor.authorKunutsor, Setor K.
dc.contributor.authorSeidu, Samuel
dc.contributor.authorLaukkanen, Jari A.
dc.date.accessioned2021-12-27T12:22:11Z
dc.date.available2021-12-27T12:22:11Z
dc.date.issued2022
dc.identifier.citationKunutsor, S. K., Seidu, S., & Laukkanen, J. A. (2022). Physical activity reduces the risk of pneumonia : systematic review and meta-analysis of 10 prospective studies involving 1,044,492 participants. <i>GeroScience</i>, <i>44</i>(1), 519-532. <a href="https://doi.org/10.1007/s11357-021-00491-2" target="_blank">https://doi.org/10.1007/s11357-021-00491-2</a>
dc.identifier.otherCONVID_103447999
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/79195
dc.description.abstractThe beneficial effects of regular physical activity in promoting health and preventing chronic diseases are well documented. The relationship between regular physical activity and the risk of pneumonia is uncertain. We aimed to evaluate the magnitude and specificity of the prospective association between regular physical activity and the risk of pneumonia using a systematic review and meta-analysis of published observational cohort studies in general populations. Relevant studies with at least 1 year of follow-up were sought from inception until 15 September 2021 in MEDLINE, Embase, Web of Science, and manual search of relevant articles. Relative risks (RRs) with 95% confidence intervals (CIs) for the maximum versus the minimal amount of physical activity groups were pooled using fixed effects meta-analysis. The quality of the evidence was evaluated using the GRADE tool. A total of 10 prospective cohort studies comprising 1,044,492 participants and 7681 events were eligible. The pooled multivariable-adjusted RR (95% CI) of pneumonia comparing the most versus the least physically active groups was 0.69 (0.64–0.74). This association was significantly modified by type of outcome (p-value for meta-regression = .002): 0.82 (0.72–0.93) for incident pneumonia and 0.64 (0.59–0.70) for pneumonia-related mortality. There was no evidence of heterogeneity and publication bias. The GRADE quality of the evidence ranged from moderate to low. Aggregate analysis of 10 cohort studies shows that regular physical activity is associated with lowered risk of incident pneumonia and pneumonia-related mortality in the general population. Physical activity types that are attractive to and feasible for high-risk populations need to be identified and encouraged. Systematic review registration: PROSPERO 2021: CRD42021277514.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofseriesGeroScience
dc.rightsCC BY 4.0
dc.subject.otherphysical activity
dc.subject.otherpneumonia
dc.subject.othercohort study
dc.subject.otherrisk factor
dc.subject.othersystematic review
dc.subject.othermeta-analysis
dc.titlePhysical activity reduces the risk of pneumonia : systematic review and meta-analysis of 10 prospective studies involving 1,044,492 participants
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202112276176
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiaineSports and Exercise Medicineen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.format.pagerange519-532
dc.relation.issn2509-2715
dc.relation.numberinseries1
dc.relation.volume44
dc.type.versionpublishedVersion
dc.rights.copyright© 2021 the Authors
dc.rights.accesslevelopenAccessfi
dc.subject.ysokeuhkokuume
dc.subject.ysosystemaattiset kirjallisuuskatsaukset
dc.subject.ysoriskitekijät
dc.subject.ysofyysinen aktiivisuus
dc.subject.ysokohorttitutkimus
dc.subject.ysometa-analyysi
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p1805
jyx.subject.urihttp://www.yso.fi/onto/yso/p29683
jyx.subject.urihttp://www.yso.fi/onto/yso/p13277
jyx.subject.urihttp://www.yso.fi/onto/yso/p23102
jyx.subject.urihttp://www.yso.fi/onto/yso/p25606
jyx.subject.urihttp://www.yso.fi/onto/yso/p27697
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1007/s11357-021-00491-2
jyx.fundinginformationThis study was supported by the NIHR Biomedical Research Centre at University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol (BRC-1215–20011). The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care.


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