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dc.contributor.authorPehkonen, Jaakko
dc.contributor.authorViinikainen, Jutta
dc.contributor.authorKari, Jaana T.
dc.contributor.authorBöckerman, Petri
dc.contributor.authorLehtimäki, Terho
dc.contributor.authorViikari, Jorma
dc.contributor.authorRaitakari, Olli
dc.date.accessioned2021-12-20T12:11:09Z
dc.date.available2021-12-20T12:11:09Z
dc.date.issued2022
dc.identifier.citationPehkonen, J., Viinikainen, J., Kari, J. T., Böckerman, P., Lehtimäki, T., Viikari, J., & Raitakari, O. (2022). Birth weight, adult weight, and cardiovascular biomarkers : Evidence from the Cardiovascular Young Finns Study. <i>Preventive Medicine</i>, <i>154</i>, Article 106894. <a href="https://doi.org/10.1016/j.ypmed.2021.106894" target="_blank">https://doi.org/10.1016/j.ypmed.2021.106894</a>
dc.identifier.otherCONVID_102952828
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/79045
dc.description.abstractThis study quantifies the causal effect of birth weight on cardiovascular biomarkers in adulthood using the Cardiovascular Risk in Young Finns Study (YFS). We apply a multivariable Mendelian randomization (MVMR) method that provides a novel approach to improve inference in causal analysis based on a mediation framework. The results show that birth weight is linked to triglyceride levels (β = −0.294; 95% CI [−0.591, 0.003]) but not to low-density lipoprotein (LDL) cholesterol levels (β = 0.007; 95% CI [−0.168, 0.183]). The total effect of birth weight on triglyceride levels is partly offset by a mediation pathway linking birth weight to adult BMI (β = 0.111; 95% CI [−0.013, 0.234]). The negative total effect is consistent with the fetal programming hypothesis. The positive indirect effect via adult BMI highlights the persistence of body weight throughout a person's life and the adverse effects of high BMI on health. The results are consistent with previous findings that both low birth weight and weight gain increase health risks in adulthood.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherElsevier BV
dc.relation.ispartofseriesPreventive Medicine
dc.rightsCC BY-NC-ND 4.0
dc.subject.othercausal mediation
dc.subject.othermultivariable Mendelian randomization
dc.subject.otherbirth weight
dc.subject.otheradult BMI
dc.subject.othertriglycerides
dc.subject.otherLDL cholesterol
dc.titleBirth weight, adult weight, and cardiovascular biomarkers : Evidence from the Cardiovascular Young Finns Study
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202112206028
dc.contributor.laitosKauppakorkeakoulufi
dc.contributor.laitosSchool of Business and Economicsen
dc.contributor.oppiaineEmpirical Microeconomicsfi
dc.contributor.oppiaineTaloustiedefi
dc.contributor.oppiainePäätöksentekoa tukeva taloustiede ja talouden kilpailukyky (painoala)fi
dc.contributor.oppiaineBasic or discovery scholarshipfi
dc.contributor.oppiaineEmpirical Microeconomicsen
dc.contributor.oppiaineEconomicsen
dc.contributor.oppiainePolicy-Relevant Economics and Competitiveness of Economy (focus area)en
dc.contributor.oppiaineBasic or discovery scholarshipen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn0091-7435
dc.relation.volume154
dc.type.versionpublishedVersion
dc.rights.copyright© 2021 the Authors
dc.rights.accesslevelopenAccessfi
dc.subject.ysotriglyseridit
dc.subject.ysomonimuuttujamenetelmät
dc.subject.ysosyntymäpaino
dc.subject.ysopainoindeksi
dc.subject.ysokausaliteetti
dc.subject.ysosydän- ja verisuonitaudit
dc.subject.ysobiomarkkerit
dc.subject.ysoLDL-kolesteroli
dc.subject.ysogeneettiset tekijät
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p23740
jyx.subject.urihttp://www.yso.fi/onto/yso/p2131
jyx.subject.urihttp://www.yso.fi/onto/yso/p21306
jyx.subject.urihttp://www.yso.fi/onto/yso/p21142
jyx.subject.urihttp://www.yso.fi/onto/yso/p333
jyx.subject.urihttp://www.yso.fi/onto/yso/p9886
jyx.subject.urihttp://www.yso.fi/onto/yso/p12288
jyx.subject.urihttp://www.yso.fi/onto/yso/p14054
jyx.subject.urihttp://www.yso.fi/onto/yso/p21661
dc.rights.urlhttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.relation.doi10.1016/j.ypmed.2021.106894
jyx.fundinginformationThe YFS has been financially supported by the Academy of Finland (grant numbers 322098, 286284, 134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117787 (Gendi), 41071 (Skidi)); Social Insurance Institution of Finland; Competitive State Research Financing of the Expert Responsibility area of Kuopio; Tampere and Turku University Hospitals (grant number X51001); Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation for Cardiovascular Research; Finnish Cultural Foundation; the Sigrid Juselius Foundation; Tampere Tuberculosis Foundation; Emil Aaltonen Foundation; Yrjö Jahnsson Foundation; Signe and Ane Gyllenberg Foundation; Jenny and Antti Wihuri Foundation; Diabetes Research Foundation of Finnish Diabetes Association; EU Horizon 2020 (grant number 755320 for TAX-INOMISIS); European Research Council (grant number 742927 for MULTIEPIGEN project); Tampere University Hospital Supporting Foundation; the Society of Finnish Clinical Chemistry.
dc.type.okmA1


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