National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio : A pooled analysis of 458 population-based studies in Asian and Western countries
NCD Risk Factor Collaboration. (2020). National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio : A pooled analysis of 458 population-based studies in Asian and Western countries. International Journal of Epidemiology, 49(1), Article 173-192. https://doi.org/10.1093/ije/dyz099
Published inInternational Journal of Epidemiology
© 2019 the Author(s)
Background: Although high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC). Our aim was to compare trends in total, HDL and nonHDL cholesterol and the total-to-HDL cholesterol ratio in Asian and Western countries. Methods: We pooled 458 population-based studies with 82.1 million participants in 23 Asian and Western countries. We estimated changes in mean total, HDL and non-HDL cholesterol and mean total-to-HDL cholesterol ratio by country, sex and age group. Results: Since similar to 1980, mean TC increased in Asian countries. In Japan and South Korea, the TC rise was due to rising HDL cholesterol, which increased by up to 0.17 mmol/L per decade in Japanese women; in China, it was due to rising non-HDL cholesterol. TC declined in Western countries, except in Polish men. The decline was largest in Finland and Norway, at similar to 0.4 mmol/L per decade. The decline in TC in most Western countries was the net effect of an increase in HDL cholesterol and a decline in non-HDL cholesterol, with the HDL cholesterol increase largest in New Zealand and Switzerland. Mean total-to-HDL cholesterol ratio declined in Japan, South Korea and most Western countries, by as much as similar to 0.7 per decade in Swiss men (equivalent to similar to 26% decline in coronary heart disease risk per decade). The ratio increased in China. Conclusions: HDL cholesterol has risen and the total-to-HDL cholesterol ratio has declined in many Western countries, Japan and South Korea, with only a weak correlation with changes in TC or non-HDL cholesterol. ...
PublisherOxford University Press
Publication in research information system
MetadataShow full item record
- Liikuntatieteiden tiedekunta 
Additional information about fundingThis work was supported by the Wellcome Trust (grant numbers 101506/Z/13/Z and Research Training Fellowship 203616/Z/16/Z). R.C. acknowledges funding from the Ministry of Health of the Czech Republic (grant number 15-27109A).
Showing items with similar title or keywords.
Menopausal status and physical activity are independently associated with cardiovascular risk factors of healthy middle-aged women : cross-sectional and longitudinal evidence Karvinen, Sira; Jergenson, Matthew J.; Hyvärinen, Matti; Aukee, Pauliina; Tammelin, Tuija; Sipilä, Sarianna; Kovanen, Vuokko; Kujala, Urho M.; Laakkonen, Eija K. (Frontiers Media, 2019)Cardiovascular disease (CVD) is the primary cause of mortality in women in developed countries. CVD risk rises with age, yet for women there is a rapid increase in CVD risk that occurs after the onset of menopause. This ...
Liikunnan ja hormonikorvaushoidon vaikutus veren HDL- ja LDL-kolesterolipitoisuuteen postmenopausaalisilla naisilla Karppinen, Miira (2021)Kardiometabolinen terveys heikkenee naisilla menopaussin jälkeen hormonitasojen muutosten seurauksena. Riskitekijöitä sydän- ja verisuonisairauksille ovat alhainen HDL- ja korkea LDL-kolesterolipitoisuus. Vaihdevuodet eli ...
Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants NCD Risk Factor Collaboration (Elsevier BV, 2020)Background Comparable global data on health and nutrition of school-aged children and adolescents are scarce. We aimed to estimate age trajectories and time trends in mean height and mean body-mass index (BMI), which ...
Taipale, Sakari; Oinas, Tomi; Karhinen, Joonas (Elsevier, 2021)The concept of aged heterogeneity has been associated with older adults' ability to adapt to the digital age without a systematic empirical analysis. We analyse retired adults' (aged 62 or more) use of traditional media ...
The effects of a 2-year physical activity and dietary intervention on plasma lipid concentrations in children : the PANIC Study Eloranta, Aino-Maija; Sallinen, Taisa; Viitasalo, Anna; Lintu, Niina; Väistö, Juuso; Jalkanen, Henna; Tompuri, Tuomo T.; Soininen, Sonja; Haapala, Eero A.; Kiiskinen, Sanna; Schnurr, Theresia M.; Kilpeläinen, Tuomas O.; Mikkonen, Santtu; Savonen, Kai; Atalay, Mustafa; Brage, Soren; Laaksonen, David E.; Lindi, Virpi; Ågren, Jyrki; Schwab, Ursula; Jääskeläinen, Jarmo; Lakka, Timo A. (Springer, 2021)Purpose: We studied the effects of a physical activity and dietary intervention on plasma lipids in a general population of children. We also investigated how lifestyle changes contributed to the intervention effects. ...