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dc.contributor.authorZand, Armin M.
dc.contributor.authorTavazoei, Mohammad Saleh
dc.contributor.authorKuznetsov, Nikolay V.
dc.date.accessioned2021-12-02T11:15:49Z
dc.date.available2021-12-02T11:15:49Z
dc.date.issued2022
dc.identifier.citationZand, A. M., Tavazoei, M. S., & Kuznetsov, N. V. (2022). Chaos and its Degradation-Promoting-Based Control in an Antithetic Integral Feedback Circuit. <i>IEEE Control Systems Letters</i>, <i>6</i>, 1622-1627. <a href="https://doi.org/10.1109/LCSYS.2021.3129320" target="_blank">https://doi.org/10.1109/LCSYS.2021.3129320</a>
dc.identifier.otherCONVID_102299519
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/78876
dc.description.abstractThis letter deals with a novel variant of antithetic integral feedback controller (AIFC) motifs which can feature robust perfect adaptation, a pervasive (desired) ability in natural (synthetic) biomolecular circuits, when coupled with a wide class of process networks to be regulated. Using the separation of timescales in the proposed kind of AIFC, here we find a reducedorder controller that captures the governing slow part of the original solutions under suitable assumptions. Inspired by R(ossler systems, we then make use of such a simpler controller to show that the antithetic circuit can exhibit chaotic behaviors with strange attractors, where the bifurcation from a homeostatic state to chaotic orbits can happen, e.g., when considering saturated Hill-type reactions for the actuation. Addition of degradation terms to the controller species, whether naturally due to dilution or exogenously using protein tags, is showcased by simulation results to be an effective solution in suppressing deterministic chaos and aperiodic oscillations. In the same vein, we recapitulate the recently introduced antithetic rein IFC motif and confirm that the promotion of degradation by a rein mechanism also can control chaos and improve the stability of closed-loop circuit.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherInstitute of Electrical and Electronics Engineers (IEEE)
dc.relation.ispartofseriesIEEE Control Systems Letters
dc.rightsIn Copyright
dc.subject.otherchaos
dc.subject.otherprocess control
dc.subject.otherdegradation
dc.subject.othermathematical models
dc.subject.otheroscillators
dc.subject.otherintegrated circuit modeling
dc.subject.otherbiological system modeling
dc.titleChaos and its Degradation-Promoting-Based Control in an Antithetic Integral Feedback Circuit
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202112025874
dc.contributor.laitosInformaatioteknologian tiedekuntafi
dc.contributor.laitosFaculty of Information Technologyen
dc.contributor.oppiaineTietotekniikkafi
dc.contributor.oppiaineComputing, Information Technology and Mathematicsfi
dc.contributor.oppiaineLaskennallinen tiedefi
dc.contributor.oppiaineMathematical Information Technologyen
dc.contributor.oppiaineComputing, Information Technology and Mathematicsen
dc.contributor.oppiaineComputational Scienceen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1622-1627
dc.relation.issn2475-1456
dc.relation.volume6
dc.type.versionacceptedVersion
dc.rights.copyright© IEEE 2021
dc.rights.accesslevelopenAccessfi
dc.subject.ysomatemaattiset mallit
dc.subject.ysosäätöteoria
dc.subject.ysoelektroniset piirit
dc.subject.ysokaaosteoria
dc.subject.ysomallit (mallintaminen)
dc.subject.ysooskillaattorit
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p11401
jyx.subject.urihttp://www.yso.fi/onto/yso/p868
jyx.subject.urihttp://www.yso.fi/onto/yso/p953
jyx.subject.urihttp://www.yso.fi/onto/yso/p6339
jyx.subject.urihttp://www.yso.fi/onto/yso/p510
jyx.subject.urihttp://www.yso.fi/onto/yso/p6393
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.doi10.1109/LCSYS.2021.3129320
jyx.fundinginformationThis work was supported by a joint Russian-Iranian program, entitled ”Oscillatory Behavior Analysis in Dynamical Systems and its Applications in Control Systems,” between St. Petersburg University and Sharif University of Technology (Corresponding author: M. S. Tavazoei)


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