Dysconnectivity of oscillatory networks in major depression disorder
Julkaistu sarjassa
JYU dissertationsTekijät
Päivämäärä
2021Tekijänoikeudet
© The Author & University of Jyväskylä
Majordepression disorder(MDD)isaprevalent psychiatric disorder globally,affecting one in six people. From the view of theoretical models, the dysconnectivityof functional networksis considereda critical causeinthe cognitive and emotional dysfunctions of MDD. However, the pathophysiology of MDD remains unclear due to the non-replicability in terms of methodologies and datasets. Both of the causes of MDD and the human connectome are incredibly complex, and novel experimental paradigms and advanced methodologies are needed to explore the pathophysiological mechanisms of MDD.
In this thesis, we explored the altered oscillatory functional connectivity in MDD during music listening conditions andresting states. In the frst study, we investigated the frequency-specifc static functional connectivity (FC) in MDD during music listening at the sensor level. We found altered FC networks and the non-lateralized effect in the delta and beta bands, and we got the best classifcation performance in the beta band by the support vector machine classifer. In the second study, we proposed a comprehensive framework to identify the dysconnectivity of oscillatory networks in MDD during resting states at the cortical source level. Fully considering the incomplete consistency in the adjacency and spectral modes between the healthy group and the MDD group and the multiway structure of the constructed data, we frst introduced the coupled tensor decomposition (CTD) model for EEG signals recorded during music listening. We identifed three hyperconnectivity networks and three hypoconnectivity networks characterizing the dysconnectivity networks in MDD under music perception. Based on the CTD model, we also explored the hyper-and hypo-connectivity networks in MDD during resting states. In the third study, we examined the dysfunction of sensor-level networks in the alpha band. In the fourth study, we explored the source-level dysconnectivity networks characterized by spatio-temporal-spectral modes of covariation in MDD.
In conclusion, this thesis investigated potential biomarkers of oscillatory networks and provided promising references to reveal the pathoconnectomics in MDD. The proposed analysis pipeline based on the CTD model can be extended to other psychiatric disorders.
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Julkaisija
Jyväskylän yliopistoISBN
978-951-39-8903-3ISSN Hae Julkaisufoorumista
2489-9003Julkaisuun sisältyy osajulkaisuja
- Artikkeli I: Liu, W., Zhang, C., Wang, X., Xu, J., Chang, Y., Ristaniemi, T., & Cong, F. (2020). Functional connectivity of major depression disorder using ongoing EEG during music perception. Clinical Neurophysiology, 131(10), 2413-2422. DOI: 10.1016/j.clinph.2020.06.031. JYX: jyx.jyu.fi/handle/123456789/71500
- Artikkeli II: Liu, W., Wang, X., Xu, J., Chang, Yi., Hämäläinen, T., & Cong, F. (2021). Identifying Oscillatory Hyperconnectivity and Hypoconnectivity Networks in Major Depression Using Coupled Tensor Decomposition. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 29, 1895-1904. DOI: 10.1109/tnsre.2021.3111564
- Artikkeli III: Liu, W., Wang, X., Cong, F. and Hämäläinen, T. (2021). Alpha Band Dysconnectivity Networks in Major Depression during Resting State. 29th European Signal Processing Conference (EUSIPCO 2021), Dublin, Ireland. Accepted.
- Artikkeli IV: Liu, W., Wang, X., Hämäläinen, T. and Cong. F. (2021). Exploring Oscillatory Dysconnectivity Networks in Major Depression during Resting State Using Coupled Tensor Decomposition. Submitted to IEEE Transactions on Biomedical Engineering.
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Näytä kaikki kuvailutiedotKokoelmat
- JYU Dissertations [806]
- Väitöskirjat [3515]
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Exploring Oscillatory Dysconnectivity Networks in Major Depression during Resting State Using Coupled Tensor Decomposition
Liu, Wenya; Wang, Xiulin; Hämäläinen, Timo; Cong, Fengyu (Institute of Electrical and Electronics Engineers (IEEE), 2022)Dysconnectivity of large-scale brain networks has been linked to major depression disorder (MDD) during resting state. Recent researches show that the temporal evolution of brain networks regulated by oscillations reveals ... -
Altered EEG Oscillatory Brain Networks During Music-Listening in Major Depression
Zhu, Yongjie; Wang, Xiaoyu; Mathiak, Klaus; Toiviainen, Petri; Ristaniemi, Tapani; Xu, Jing; Chang, Yi; Cong, Fengyu (World Scientific, 2021)To examine the electrophysiological underpinnings of the functional networks involved in music listening, previous approaches based on spatial independent component analysis (ICA) have recently been used to ongoing ... -
Identifying Oscillatory Hyperconnectivity and Hypoconnectivity Networks in Major Depression Using Coupled Tensor Decomposition
Liu, Wenya; Wang, Xiulin; Xu, Jing; Chang, Yi.; Hämäläinen, Timo; Cong, Fengyu (Institute of Electrical and Electronics Engineers (IEEE), 2021)Previous researches demonstrate that major depression disorder (MDD) is associated with widespread network dysconnectivity, and the dynamics of functional connectivity networks are important to delineate the neural mechanisms ... -
Functional connectivity of major depression disorder using ongoing EEG during music perception
Liu, Wenya; Zhang, Chi; Wang, Xiaoyu; Xu, Jing; Chang, Yi; Ristaniemi, Tapani; Cong, Fengyu (Elsevier BV, 2020)Objective The functional connectivity (FC) of major depression disorder (MDD) has not been well studied under naturalistic and continuous stimuli conditions. In this study, we investigated the frequency-specific FC of MDD ... -
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