Showing items with similar title or keywords.

• No evidence of EMAST in whole genome sequencing data from 248 colorectal cancers 

  Kondelin, Johanna; Martin, Samantha; Katainen, Riku; Renkonen‐Sinisalo, Laura; Lepistö, Anna; Koskensalo, Selja; Böhm, Jan; Mecklin, Jukka‐Pekka; Cajuso, Tatiana; Hänninen, Ulrika A.; Välimäki, Niko; Ravantti, Janne; Rajamäki, Kristiina; Palin, Kimmo; Aaltonen, Lauri A. (John Wiley & Sons, 2021)

  Microsatellite instability (MSI) is caused by defective DNA mismatch repair (MMR), and manifests as accumulation of small insertions and deletions (indels) in short tandem repeats of the genome. Another form of repeat ...

• Somatic mutation profiles as molecular classifiers of ulcerative colitis‐associated colorectal cancer 

  Mäki‐Nevala, Satu; Ukwattage, Sanjeevi; Olkinuora, Alisa; Almusa, Henrikki; Ahtiainen, Maarit; Ristimäki, Ari; Seppälä, Toni; Lepistö, Anna; Mecklin, Jukka‐Pekka; Peltomäki, Päivi (John Wiley & Sons, 2021)

  Ulcerative colitis increases colorectal cancer risk by mechanisms that remain incompletely understood. We approached this question by determining the genetic and epigenetic profiles of colitis‐associated colorectal carcinomas ...

• Immune Contexture of MMR-Proficient Primary Colorectal Cancer and Matched Liver and Lung Metastases 

  Ahtiainen, Maarit; Elomaa, Hanna; Väyrynen, Juha P.; Wirta, Erkki-Ville; Kuopio, Teijo; Helminen, Olli; Seppälä, Toni T.; Kellokumpu, Ilmo; Mecklin, Jukka-Pekka (MDPI AG, 2021)

  Purpose: To evaluate immune cell infiltration, the programmed death-1/programmed death ligand-1 (PD-1/PD-L1) expression and their prognostic value in a series of mismatch proficient (pMMR) CRC with matched liver and lung ...

• Incidence and management of patients with colorectal cancer and synchronous and metachronous colorectal metastases : a population-based study 

  Väyrynen, V.; Wirta, E; Seppälä, T.; Sihvo, E.; Mecklin, J-P.; Vasala, K.; Kellokumpu, I. (John Wiley & Sons, 2020)

  Background This population-based study aimed to examine the incidence, patterns and results of multimodal management of metastatic colorectal cancer. Methods A retrospective population-based study was conducted on patients ...

• Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study : a double-blind, randomised, placebo-controlled trial 

  Burn, John; Sheth, Harsh; Elliott, Faye; Reed, Lynn; Macrae, Finlay; Mecklin, Jukka-Pekka; Möslein, Gabriela; McRonald, Fiona E.; Bertario, Lucio; Evans, D. Gareth; Gerdes, Anne-Marie; Ho, Judy W. C.; Lindblom, Annika; Morrison, Patrick J.; Rashbass, Jem; Ramesar, Raj; Seppälä, Toni; Thomas, Huw J. W.; Pylvänäinen, Kirsi; Borthwick, Gillian M.; Mathers, John C.; Bishop, D. Timothy (Elsevier, 2020)

  Background: Lynch syndrome is associated with an increased risk of colorectal cancer and with a broader spectrum of cancers, especially endometrial cancer. In 2011, our group reported long-term cancer outcomes (mean follow-up ...