Exome and immune cell score analyses reveal great variation within synchronous primary colorectal cancers

Hänninen, Ulrika A.; Wirta, Erkki-Ville; Katainen, Riku; Tanskanen, Tomas; Hamberg, Jiri; Taipale, Minna; Böhm, Jan; Renkonen-Sinisalo, Laura; Lepistö, Anna; Forsström, Linda M.; Pitkänen, Esa; Palin, Kimmo; Seppälä, Toni T.; Mäkinen, Netta; Mecklin, Jukka-Pekka; Aaltonen, Lauri A.

doi:10.1038/s41416-019-0427-4

dc.contributor.author	Hänninen, Ulrika A.
dc.contributor.author	Wirta, Erkki-Ville
dc.contributor.author	Katainen, Riku
dc.contributor.author	Tanskanen, Tomas
dc.contributor.author	Hamberg, Jiri
dc.contributor.author	Taipale, Minna
dc.contributor.author	Böhm, Jan
dc.contributor.author	Renkonen-Sinisalo, Laura
dc.contributor.author	Lepistö, Anna
dc.contributor.author	Forsström, Linda M.
dc.contributor.author	Pitkänen, Esa
dc.contributor.author	Palin, Kimmo
dc.contributor.author	Seppälä, Toni T.
dc.contributor.author	Mäkinen, Netta
dc.contributor.author	Mecklin, Jukka-Pekka
dc.contributor.author	Aaltonen, Lauri A.
dc.date.accessioned	2021-08-03T11:33:07Z
dc.date.available	2021-08-03T11:33:07Z
dc.date.issued	2019
dc.identifier.citation	Hänninen, U. A., Wirta, E.-V., Katainen, R., Tanskanen, T., Hamberg, J., Taipale, M., Böhm, J., Renkonen-Sinisalo, L., Lepistö, A., Forsström, L. M., Pitkänen, E., Palin, K., Seppälä, T. T., Mäkinen, N., Mecklin, J.-P., & Aaltonen, L. A. (2019). Exome and immune cell score analyses reveal great variation within synchronous primary colorectal cancers. <i>British Journal of Cancer</i>, <i>120</i>(9), 922-930. <a href="https://doi.org/10.1038/s41416-019-0427-4" target="_blank">https://doi.org/10.1038/s41416-019-0427-4</a>
dc.identifier.other	CONVID_28984061
dc.identifier.other	TUTKAID_81033
dc.identifier.uri	https://jyx.jyu.fi/handle/123456789/77269
dc.format.mimetype	application/pdf
dc.language.iso	eng
dc.publisher	Nature Publishing Group
dc.relation.ispartofseries	British Journal of Cancer
dc.rights	CC BY 4.0
dc.subject.other	cancer genetics
dc.subject.other	colorectal cancer
dc.title	Exome and immune cell score analyses reveal great variation within synchronous primary colorectal cancers
dc.type	article
dc.identifier.urn	URN:NBN:fi:jyu-202108034437
dc.contributor.laitos	Liikuntatieteellinen tiedekunta	fi
dc.contributor.laitos	Faculty of Sport and Health Sciences	en
dc.type.uri	http://purl.org/eprint/type/JournalArticle
dc.type.coar	http://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatus	peerReviewed
dc.format.pagerange	922-930
dc.relation.issn	0007-0920
dc.relation.numberinseries	9
dc.relation.volume	120
dc.type.version	publishedVersion
dc.rights.copyright	© 2019 Cancer Research UK
dc.rights.accesslevel	openAccess	fi
dc.subject.yso	suolistosyövät
dc.subject.yso	DNA-analyysi
dc.format.content	fulltext
jyx.subject.uri	http://www.yso.fi/onto/yso/p25845
jyx.subject.uri	http://www.yso.fi/onto/yso/p25695
dc.rights.url	https://creativecommons.org/licenses/by/4.0/
dc.relation.doi	10.1038/s41416-019-0427-4
dc.type.okm	A1

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Somatic mutation profiles as molecular classifiers of ulcerative colitis‐associated colorectal cancer

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No evidence of EMAST in whole genome sequencing data from 248 colorectal cancers

Kondelin, Johanna; Martin, Samantha; Katainen, Riku; Renkonen‐Sinisalo, Laura; Lepistö, Anna; Koskensalo, Selja; Böhm, Jan; Mecklin, Jukka‐Pekka; Cajuso, Tatiana; Hänninen, Ulrika A.; Välimäki, Niko; Ravantti, Janne; Rajamäki, Kristiina; Palin, Kimmo; Aaltonen, Lauri A. (John Wiley & Sons, 2021)

Microsatellite instability (MSI) is caused by defective DNA mismatch repair (MMR), and manifests as accumulation of small insertions and deletions (indels) in short tandem repeats of the genome. Another form of repeat ...
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Ahtiainen, Maarit; Elomaa, Hanna; Väyrynen, Juha P.; Wirta, Erkki-Ville; Kuopio, Teijo; Helminen, Olli; Seppälä, Toni T.; Kellokumpu, Ilmo; Mecklin, Jukka-Pekka (MDPI AG, 2021)

Purpose: To evaluate immune cell infiltration, the programmed death-1/programmed death ligand-1 (PD-1/PD-L1) expression and their prognostic value in a series of mismatch proficient (pMMR) CRC with matched liver and lung ...
Impact of Primary Tumor Location on Demographics, Resectability, Outcomes, and Quality of Life in Finnish Metastatic Colorectal Cancer Patients (Subgroup Analysis of the RAXO Study)

Aho, Sonja; Osterlund, Emerik; Ristimäki, Ari; Nieminen, Lasse; Sundström, Jari; Mäkinen, Markus J.; Kuopio, Teijo; Kytölä, Soili; Ålgars, Annika; Ristamäki, Raija; Heervä, Eetu; Kallio, Raija; Halonen, Päivi; Soveri, Leena-Maija; Nordin, Arno; Uutela, Aki; Salminen, Tapio; Stedt, Hanna; Lamminmäki, Annamarja; Muhonen, Timo; Kononen, Juha; Glimelius, Bengt; Isoniemi, Helena; Lehto, Juho T.; Lehtomäki, Kaisa; Osterlund, Pia (MDPI AG, 2024)

The primary tumor location (PTL) is associated with the phenotype, metastatic sites, mutations, and outcomes of metastatic colorectal cancer (mCRC) patients, but this has mostly been studied according to sidedness (right ...
Incidence and management of patients with colorectal cancer and synchronous and metachronous colorectal metastases : a population-based study

Väyrynen, V.; Wirta, E; Seppälä, T.; Sihvo, E.; Mecklin, J-P.; Vasala, K.; Kellokumpu, I. (John Wiley & Sons, 2020)

Background This population-based study aimed to examine the incidence, patterns and results of multimodal management of metastatic colorectal cancer. Methods A retrospective population-based study was conducted on patients ...

Exome and immune cell score analyses reveal great variation within synchronous primary colorectal cancers

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Somatic mutation profiles as molecular classifiers of ulcerative colitis‐associated colorectal cancer ﻿

No evidence of EMAST in whole genome sequencing data from 248 colorectal cancers ﻿

Immune Contexture of MMR-Proficient Primary Colorectal Cancer and Matched Liver and Lung Metastases ﻿

Impact of Primary Tumor Location on Demographics, Resectability, Outcomes, and Quality of Life in Finnish Metastatic Colorectal Cancer Patients (Subgroup Analysis of the RAXO Study) ﻿

Incidence and management of patients with colorectal cancer and synchronous and metachronous colorectal metastases : a population-based study ﻿

Somatic mutation profiles as molecular classifiers of ulcerative colitis‐associated colorectal cancer

No evidence of EMAST in whole genome sequencing data from 248 colorectal cancers

Immune Contexture of MMR-Proficient Primary Colorectal Cancer and Matched Liver and Lung Metastases

Impact of Primary Tumor Location on Demographics, Resectability, Outcomes, and Quality of Life in Finnish Metastatic Colorectal Cancer Patients (Subgroup Analysis of the RAXO Study)

Incidence and management of patients with colorectal cancer and synchronous and metachronous colorectal metastases : a population-based study