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dc.contributor.authorRoine, Eija
dc.contributor.authorSintonen, Harri
dc.contributor.authorKellokumpu-Lehtinen, Pirkko-Liisa
dc.contributor.authorPenttinen, Heidi
dc.contributor.authorUtriainen, Meri
dc.contributor.authorVehmanen, Leena
dc.contributor.authorHuovinen, Riikka
dc.contributor.authorKautiainen, Hannu
dc.contributor.authorNikander, Riku
dc.contributor.authorBlomqvist, Carl
dc.contributor.authorHakamies-Blomqvist, Liisa
dc.contributor.authorSaarto, Tiina
dc.date.accessioned2021-07-06T09:13:50Z
dc.date.available2021-07-06T09:13:50Z
dc.date.issued2021
dc.identifier.citationRoine, E., Sintonen, H., Kellokumpu-Lehtinen, P.-L., Penttinen, H., Utriainen, M., Vehmanen, L., Huovinen, R., Kautiainen, H., Nikander, R., Blomqvist, C., Hakamies-Blomqvist, L., & Saarto, T. (2021). Long-term health-related quality of life of breast cancer survivors remains impaired compared to the age-matched general population especially in young women : Results from the prospective controlled BREX exercise study. <i>Breast</i>, <i>59</i>, 110-116. <a href="https://doi.org/10.1016/j.breast.2021.06.012" target="_blank">https://doi.org/10.1016/j.breast.2021.06.012</a>
dc.identifier.otherCONVID_98418254
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/77015
dc.description.abstractObjective To investigate long-term health-related quality of life (HRQoL) changes over time in younger compared to older disease-free breast cancer survivors who participated in a prospective randomized exercise trial. Methods Survivors (aged 35–68 years) were randomized to a 12-month exercise trial after adjuvant treatment and followed up for ten years. HRQoL was assessed with the generic 15D instrument during follow-up and the younger (baseline age ≤ 50) and older (age >50) survivors’ HRQoL was compared to that of the age-matched general female population (n = 892). The analysis included 342 survivors. Results The decline of HRQoL compared to the population was steeper and recovery slower in the younger survivors (p for interaction < 0.001). The impairment was also larger among the younger survivors (p = 0.027) whose mean HRQoL deteriorated for three years after treatment and started to slowly improve thereafter but still remained below the population level after ten years (difference −0.017, 95% CI: 0.031 to −0.004). The older survivors’ mean HRQoL gradually approached the population level during the first five years but also remained below it at ten years (difference −0.019, 95% CI: 0.032 to −0.007). The largest differences were on the dimensions of sleeping and sexual activity, on which both age groups remained below the population level throughout the follow-up. Conclusions HRQoL developed differently in younger and older survivors both regarding the most affected dimensions of HRQoL and the timing of the changes during follow-up. HRQoL of both age groups remained below the population level even ten years after treatment.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofseriesBreast
dc.rightsCC BY-NC-ND 4.0
dc.subject.otherbreast neoplasms
dc.subject.othercancer survivors
dc.subject.otherexercise
dc.subject.otherfollow-up studies
dc.subject.otherhealth-related quality of life
dc.subject.otherutility
dc.titleLong-term health-related quality of life of breast cancer survivors remains impaired compared to the age-matched general population especially in young women : Results from the prospective controlled BREX exercise study
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202107064201
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.format.pagerange110-116
dc.relation.issn0960-9776
dc.relation.volume59
dc.type.versionpublishedVersion
dc.rights.copyright© 2021 The Authors. Published by Elsevier Ltd.
dc.rights.accesslevelopenAccessfi
dc.subject.ysokuntoliikunta
dc.subject.ysoelämänlaatu
dc.subject.ysoseurantatutkimus
dc.subject.ysorintasyöpä
dc.subject.ysotoipuminen
dc.subject.ysoliikuntahoito
dc.subject.ysosyöpätaudit
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p3708
jyx.subject.urihttp://www.yso.fi/onto/yso/p10759
jyx.subject.urihttp://www.yso.fi/onto/yso/p13719
jyx.subject.urihttp://www.yso.fi/onto/yso/p20019
jyx.subject.urihttp://www.yso.fi/onto/yso/p339
jyx.subject.urihttp://www.yso.fi/onto/yso/p7811
jyx.subject.urihttp://www.yso.fi/onto/yso/p678
dc.rights.urlhttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.relation.doi10.1016/j.breast.2021.06.012
jyx.fundinginformationThe BREX study was supported by the Cancer Society of Finland and Competitive State Research Financing of the Expert Responsibility of Tampere University Hospital.


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