Stromal hyaluronan accumulation is associated with low immune response and poor prognosis in pancreatic cancer
Tahkola, K., Ahtiainen, M., Mecklin, J.-P., Kellokumpu, I., Laukkarinen, J., Tammi, M., Tammi, R., Väyrynen, J. P., & Böhm, J. (2021). Stromal hyaluronan accumulation is associated with low immune response and poor prognosis in pancreatic cancer. Scientific Reports, 11, Article 12216. https://doi.org/10.1038/s41598-021-91796-x
Published in
Scientific ReportsAuthors
Date
2021Copyright
© The Author(s) 2021
Hyaluronan (HA) accumulation has been associated with poor survival in various cancers, but the mechanisms for this phenomenon are still unclear. The aim of this study was to investigate the prognostic significance of stromal HA accumulation and its association with host immune response in pancreatic ductal adenocarcinoma (PDAC). The study material consisted of 101 radically treated patients for PDAC from a single geographical area. HA staining was evaluated using a HA-specific probe, and the patterns of CD3, CD8, CD73 and PD-L1 expression were evaluated using immunohistochemistry. HA staining intensity of tumour stromal areas was assessed digitally using QuPath. CD3- and CD8-based immune cell score (ICS) was determined. High-level stromal HA expression was significantly associated with poor disease-specific survival (p = 0.037) and overall survival (p = 0.013) In multivariate analysis, high-level stromal HA expression was an independent negative prognostic factor together with histopathological grade, TNM stage, CD73 positivity in tumour cells and low ICS. Moreover, high-level stromal HA expression was associated with low ICS (p = 0.017). In conclusion, stromal HA accumulation is associated with poor survival and low immune response in PDAC.
...
Publisher
Nature Publishing GroupISSN Search the Publication Forum
2045-2322Publication in research information system
https://converis.jyu.fi/converis/portal/detail/Publication/97851070
Metadata
Show full item recordCollections
- Liikuntatieteiden tiedekunta [3076]
Additional information about funding
This study received funding from the Cancer Foundation Finland, the Finnish Medical Foundation, the Jane and Aatos Erkko Foundation, the Emil Aaltonen Foundation and the State Research Funding.License
Related items
Showing items with similar title or keywords.
-
Prognostic impact of CD73 expression and its relationship to PD-L1 in patients with radically treated pancreatic cancer
Tahkola, Kyösti; Ahtiainen, Maarit; Kellokumpu, Ilmo; Mecklin, Jukka-Pekka; Laukkarinen Johanna; Laakkonen, Joni; Kenessey, Istvan; Jalkanen, Sirpa; Salmi, Marko; Böhm, Jan (Springer, 2021)Immune suppressing molecule CD73 is overexpressed in various cancers and associated with poor survival. Little is so far known about the predictive value of CD73 in pancreatic ductal adenocarcinoma (PDAC). The purpose of ... -
IGF2BP3 Associates with Proliferative Phenotype and Prognostic Features in B-Cell Acute Lymphoblastic Leukemia
Mäkinen, Artturi; Nikkilä, Atte; Haapaniemi, Teppo; Oksa, Laura; Mehtonen, Juha; Vänskä, Matti; Heinäniemi, Merja; Paavonen, Timo; Lohi, Olli (MDPI, 2021)The oncofetal protein insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) belongs to a family of RNA-binding proteins involved in localization, stability, and translational regulation of target RNAs. IGF2BP3 is ... -
The expression and prognostic relevance of programmed cell death protein 1 in tongue squamous cell carcinoma
Tervo, Sanni; Seppälä, Miia; Rautiainen, Markus; Huhtala, Heini; Salo, Tuula; Al‐Samadi, Ahmed; Kuopio, Teijo; Ahtiainen, Maarit; Tommola, Satu; Paavonen, Timo; Toppila‐Salmi, Sanna (Wiley-Blackwell, 2020)Background Programmed cell death protein 1 (PD‐1) is an immune checkpoint receptor which plays an important role in a patient´s immune responses to microbial and cancer antigens. It is expressed in tumor infiltrating ... -
Analysis of Mucin glycoprotein expression in colorectal cancer
Tarkiainen, Vilma (2023)Colorectal cancer is a global problem and one of the leading causes of cancer-associated deaths. It is diagnosed with standard classification based on the tumour node metastasis classification system provided by the Union ... -
Immunophenotype based on inflammatory cells, PD-1/PD-L1 signalling pathway and M2 macrophages predicts survival in gastric cancer
Junttila, Anna; Helminen, Olli; Väyrynen, Juha P.; Ahtiainen, Maarit; Kenessey, Istvan; Jalkanen, Sirpa; Mecklin, Jukka-Pekka; Kellokumpu, Ilmo; Kuopio, Teijo; Böhm, Jan; Mrena, Johanna (Nature Publishing Group, 2020)Background: Immune response against cancer has prognostic impact but its role in gastric cancer is poorly known. The aim of the study was to assess the prognostic significance of immune cell score (CD3+, CD8+), tumour ...