The expression and prognostic relevance of programmed cell death protein 1 in tongue squamous cell carcinoma
Tervo, S., Seppälä, M., Rautiainen, M., Huhtala, H., Salo, T., Al‐Samadi, A., Kuopio, T., Ahtiainen, M., Tommola, S., Paavonen, T., & Toppila‐Salmi, S. (2020). The expression and prognostic relevance of programmed cell death protein 1 in tongue squamous cell carcinoma. APMIS, 128(12), 626-636. https://doi.org/10.1111/apm.13084
© Wiley-Blackwell, 2020
Background Programmed cell death protein 1 (PD‐1) is an immune checkpoint receptor which plays an important role in a patient´s immune responses to microbial and cancer antigens. It is expressed in tumor infiltrating lymphocytes (TILs) with many different malignancies. The aim of the study was to evaluate PD‐1 expression and its prognostic value in tongue cancer. Methods The data of tongue squamous cell carcinoma (TSCC) patients (N=81) treated in Tampere University Hospital between 1999‐2013 was used. Control data consisted of patients with non‐malignant tongue mucous membrane lesions (N=48). The formalin‐fixed paraffin‐embedded samples were stained immunohistochemically and scanned via digital microscope. The staining of PD‐1 was examined semi‐quantitatively. Results The density and intensity of PD‐1+ cells were significantly higher in TSCC than in control samples. The expression of PD‐1 correlated with better survival. Conclusions The expression of PD‐1 could be a potential prognostic marker in TSCC. Further research using larger sample size is needed. ...
ISSN Search the Publication Forum0903-4641
Publication in research information system
MetadataShow full item record
Additional information about fundingThe study was supported in part by research grants from the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital, the Helsinki University Central Hospital Research Fund, Tampere Tuberculosis association, the Finnish Association of Otorhinolaryngology and Head and Neck Surgery, Jane and Aatos Erkko Foundation, Paulo Foundation, Yrjö Jahnsson Foundation, Foundation of the Finnish Anti-Tuberculosis Association and Väinö and Laina Kivi Foundation. ...
Showing items with similar title or keywords.
IGF2BP3 Associates with Proliferative Phenotype and Prognostic Features in B-Cell Acute Lymphoblastic Leukemia Mäkinen, Artturi; Nikkilä, Atte; Haapaniemi, Teppo; Oksa, Laura; Mehtonen, Juha; Vänskä, Matti; Heinäniemi, Merja; Paavonen, Timo; Lohi, Olli (MDPI, 2021)The oncofetal protein insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) belongs to a family of RNA-binding proteins involved in localization, stability, and translational regulation of target RNAs. IGF2BP3 is ...
Prognostic impact of CD73 expression and its relationship to PD-L1 in patients with radically treated pancreatic cancer Tahkola, Kyösti; Ahtiainen, Maarit; Kellokumpu, Ilmo; Mecklin, Jukka-Pekka; Laukkarinen Johanna; Laakkonen, Joni; Kenessey, Istvan; Jalkanen, Sirpa; Salmi, Marko; Böhm, Jan (Springer, 2021)Immune suppressing molecule CD73 is overexpressed in various cancers and associated with poor survival. Little is so far known about the predictive value of CD73 in pancreatic ductal adenocarcinoma (PDAC). The purpose of ...
Resectability, conversion, metastasectomy and outcome according to RAS and BRAF status for metastatic colorectal cancer in the prospective RAXO study Uutela, Aki; Osterlund, Emerik; Halonen, Päivi; Kallio, Raija; Ålgars, Annika; Salminen, Tapio; Lamminmäki, Annamarja; Soveri, Leena-Maija; Ristamäki, Raija; Lehtomäki, Kaisa; Stedt, Hanna; Heervä, Eetu; Muhonen, Timo; Kononen, Juha; Nordin, Arno; Ovissi, Ali; Kytölä, Soili; Keinänen, Mauri; Sundström, Jari; Nieminen, Lasse; Mäkinen, Markus J.; Kuopio, Teijo; Ristimäki, Ari; Isoniemi, Helena; Osterlund, Pia (Nature Publishing Group, 2022)Background Outcomes after metastasectomy for metastatic colorectal cancer (mCRC) vary with RAS and BRAF mutational status, but their effects on resectability and conversion rates have not been extensively studied. Me ...
Predictive value of p53, Ki67 and TLR5 in neoplastic progression of Barrett’s esophagus : a matched case-control study Helminen, Olli; Melkko, Jukka; Saarnio, Juha; Sihvo, Eero; Kuopio, Teijo; Ohtonen, Pasi; Kauppila, Joonas H.; Karttunen, Tuomo J.; Huhta, Heikki (Springer, 2022)Barrett’s esophagus progresses to high-grade dysplasia or cancer along the well-established metaplasia-dysplasia-adenocarcinoma sequence. The aim of this study was to evaluate the value of p53, Ki67, and toll-like receptor ...
Prognostic Value of Immune Environment Analysis in Small Bowel Adenocarcinomas with Verified Mutational Landscape and Predisposing Conditions Wirta, Erkki-Ville; Szeto, Säde; Hänninen, Ulrika; Ahtiainen, Maarit; Böhm, Jan; Mecklin, Jukka-Pekka; Aaltonen, Lauri A.; Seppälä, Toni T. (MDPI, 2020)Background: Small bowel adenocarcinoma (SBA) is a rare yet insidious cancer with poor survival. The abundance of tumour-infiltrating lymphocytes is associated with improved survival, but the role of the programmed ...