The expression and prognostic relevance of programmed cell death protein 1 in tongue squamous cell carcinoma
Tervo, S., Seppälä, M., Rautiainen, M., Huhtala, H., Salo, T., Al‐Samadi, A., Kuopio, T., Ahtiainen, M., Tommola, S., Paavonen, T., & Toppila‐Salmi, S. (2020). The expression and prognostic relevance of programmed cell death protein 1 in tongue squamous cell carcinoma. APMIS, 128(12), 626-636. https://doi.org/10.1111/apm.13084
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2020Copyright
© Wiley-Blackwell, 2020
Background
Programmed cell death protein 1 (PD‐1) is an immune checkpoint receptor which plays an important role in a patient´s immune responses to microbial and cancer antigens. It is expressed in tumor infiltrating lymphocytes (TILs) with many different malignancies. The aim of the study was to evaluate PD‐1 expression and its prognostic value in tongue cancer.
Methods
The data of tongue squamous cell carcinoma (TSCC) patients (N=81) treated in Tampere University Hospital between 1999‐2013 was used. Control data consisted of patients with non‐malignant tongue mucous membrane lesions (N=48). The formalin‐fixed paraffin‐embedded samples were stained immunohistochemically and scanned via digital microscope. The staining of PD‐1 was examined semi‐quantitatively.
Results
The density and intensity of PD‐1+ cells were significantly higher in TSCC than in control samples. The expression of PD‐1 correlated with better survival.
Conclusions
The expression of PD‐1 could be a poten
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Wiley-BlackwellISSN Search the Publication Forum
0903-4641Keywords
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https://converis.jyu.fi/converis/portal/detail/Publication/42231605
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Additional information about funding
The study was supported in part by research grants from the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital, the Helsinki University Central Hospital Research Fund, Tampere Tuberculosis association, the Finnish Association of Otorhinolaryngology and Head and Neck Surgery, Jane and Aatos Erkko Foundation, Paulo Foundation, Yrjö Jahnsson Foundat ...
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Except where otherwise noted, this item's license is described as In Copyright