Show simple item record

dc.contributor.authorVia, Jack Dalla
dc.contributor.authorOwen, Patrick J.
dc.contributor.authorDaly, Robin M.
dc.contributor.authorMundell, Niamh L.
dc.contributor.authorLivingston, Patricia M.
dc.contributor.authorRantalainen, Timo
dc.contributor.authorFoulkes, Stephen J.
dc.contributor.authorMillar, Jeremy L.
dc.contributor.authorMurphy, Declan G.
dc.contributor.authorFraser, Steve F.
dc.date.accessioned2021-04-21T05:41:29Z
dc.date.available2021-04-21T05:41:29Z
dc.date.issued2021
dc.identifier.citationVia, J. D., Owen, P. J., Daly, R. M., Mundell, N. L., Livingston, P. M., Rantalainen, T., Foulkes, S. J., Millar, J. L., Murphy, D. G., & Fraser, S. F. (2021). Musculoskeletal Responses to Exercise plus Nutrition in Men with Prostate Cancer on Androgen Deprivation : A 12-month RCT. <i>Medicine and Science in Sports and Exercise</i>, <i>53</i>(10), 2054-2065. <a href="https://doi.org/10.1249/mss.0000000000002682" target="_blank">https://doi.org/10.1249/mss.0000000000002682</a>
dc.identifier.otherCONVID_67371871
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/75142
dc.description.abstractPurpose Androgen deprivation therapy (ADT) for prostate cancer (PCa) has multiple adverse effects on musculoskeletal health. This 12-month randomised controlled trial aimed to assess the effects of multi-component exercise training combined with whey protein, calcium and vitamin D supplementation on bone mineral density (BMD), structure and strength, body composition, muscle strength and physical function in ADT-treated men. Methods Seventy ADT-treated men were randomised to exercise plus supplementation (Ex+Suppl; n=34) or usual care (Control; n=36). Ex+Suppl involved thrice weekly progressive resistance training plus weight-bearing impact exercise with daily multi-nutrient supplementation. Primary outcomes were DXA hip and spine areal BMD. Secondary outcomes included: tibia and radius pQCT volumetric BMD, bone structure and strength; DXA body composition; pQCT muscle and fat cross-sectional area and muscle density; muscle strength and physical function. Results Sixty men (86%) completed the study. Mean exercise and supplement adherence were 56% and 77%, respectively. There were no effects of the intervention on bone or body composition outcomes. Ex+Suppl improved leg muscle strength (net difference [95% CI] 14.5% [-0.2, 29.2], P=0.007) and dynamic mobility (four-square-step test time, -9.3% [-17.3, -1.3], P=0.014) relative to controls. Per-protocol analysis of adherent participants (≥66% exercise, ≥80% supplement) showed Ex+Suppl preserved femoral neck aBMD (1.9% [0.1, 3.8], P=0.026) and improved total body lean mass (1.0 kg [-0.23, 2.22], P=0.044) relative to controls. Conclusion Exercise training combined with multi-nutrient supplementation had limited effect on ameliorating the adverse musculoskeletal consequences of ADT, likely related to the modest intervention adherence.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofseriesMedicine and Science in Sports and Exercise
dc.rightsIn Copyright
dc.subject.otherexercise
dc.subject.othernutrition
dc.subject.othercancer
dc.subject.otherbone
dc.subject.othermuscle
dc.subject.otherandrogen deprivation therapy
dc.titleMusculoskeletal Responses to Exercise plus Nutrition in Men with Prostate Cancer on Androgen Deprivation : A 12-month RCT
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202104212441
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineBiomekaniikkafi
dc.contributor.oppiaineGerontology and Public Healthen
dc.contributor.oppiaineBiomechanicsen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.format.pagerange2054-2065
dc.relation.issn0195-9131
dc.relation.numberinseries10
dc.relation.volume53
dc.type.versionacceptedVersion
dc.rights.copyright© 2021 American College of Sports Medicine
dc.rights.accesslevelopenAccessfi
dc.subject.ysoluusto
dc.subject.ysoeturauhassyöpä
dc.subject.ysosyöpätaudit
dc.subject.ysokuntoliikunta
dc.subject.ysoravinto
dc.subject.ysolihakset
dc.subject.ysosyöpähoidot
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p7233
jyx.subject.urihttp://www.yso.fi/onto/yso/p14843
jyx.subject.urihttp://www.yso.fi/onto/yso/p678
jyx.subject.urihttp://www.yso.fi/onto/yso/p3708
jyx.subject.urihttp://www.yso.fi/onto/yso/p3671
jyx.subject.urihttp://www.yso.fi/onto/yso/p2784
jyx.subject.urihttp://www.yso.fi/onto/yso/p27422
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.doi10.1249/mss.0000000000002682
jyx.fundinginformationThe study received in-kind support from YMCA Victoria, Ostelin and Omniblend. Facilities, equipment and internal funding were provided by Deakin University.


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

In Copyright
Except where otherwise noted, this item's license is described as In Copyright