Musculoskeletal Responses to Exercise plus Nutrition in Men with Prostate Cancer on Androgen Deprivation : A 12-month RCT
Via, J. D., Owen, P. J., Daly, R. M., Mundell, N. L., Livingston, P. M., Rantalainen, T., Foulkes, S. J., Millar, J. L., Murphy, D. G., & Fraser, S. F. (2021). Musculoskeletal Responses to Exercise plus Nutrition in Men with Prostate Cancer on Androgen Deprivation : A 12-month RCT. Medicine and Science in Sports and Exercise, 53(10), 2054-2065. https://doi.org/10.1249/mss.0000000000002682
Published inMedicine and Science in Sports and Exercise
Embargoed until: 2022-04-16Request copy from author
© 2021 American College of Sports Medicine
Purpose Androgen deprivation therapy (ADT) for prostate cancer (PCa) has multiple adverse effects on musculoskeletal health. This 12-month randomised controlled trial aimed to assess the effects of multi-component exercise training combined with whey protein, calcium and vitamin D supplementation on bone mineral density (BMD), structure and strength, body composition, muscle strength and physical function in ADT-treated men. Methods Seventy ADT-treated men were randomised to exercise plus supplementation (Ex+Suppl; n=34) or usual care (Control; n=36). Ex+Suppl involved thrice weekly progressive resistance training plus weight-bearing impact exercise with daily multi-nutrient supplementation. Primary outcomes were DXA hip and spine areal BMD. Secondary outcomes included: tibia and radius pQCT volumetric BMD, bone structure and strength; DXA body composition; pQCT muscle and fat cross-sectional area and muscle density; muscle strength and physical function. Results Sixty men (86%) completed the study. Mean exercise and supplement adherence were 56% and 77%, respectively. There were no effects of the intervention on bone or body composition outcomes. Ex+Suppl improved leg muscle strength (net difference [95% CI] 14.5% [-0.2, 29.2], P=0.007) and dynamic mobility (four-square-step test time, -9.3% [-17.3, -1.3], P=0.014) relative to controls. Per-protocol analysis of adherent participants (≥66% exercise, ≥80% supplement) showed Ex+Suppl preserved femoral neck aBMD (1.9% [0.1, 3.8], P=0.026) and improved total body lean mass (1.0 kg [-0.23, 2.22], P=0.044) relative to controls. Conclusion Exercise training combined with multi-nutrient supplementation had limited effect on ameliorating the adverse musculoskeletal consequences of ADT, likely related to the modest intervention adherence. ...
PublisherLippincott Williams & Wilkins
Publication in research information system
MetadataShow full item record
- Liikuntatieteiden tiedekunta 
Additional information about fundingThe study received in-kind support from YMCA Victoria, Ostelin and Omniblend. Facilities, equipment and internal funding were provided by Deakin University.
Showing items with similar title or keywords.
Radiotherapy before or during androgen-deprivation therapy does not blunt the exercise-induced body composition protective effects in prostate cancer patients : A secondary analysis of two randomized controlled trials Newton, Robert U.; Mavropalias, Georgios; Fragala, Maren S.; Kraemer, William J.; Häkkinen, Keijo; Taaffe, Dennis R.; Spry, Nigel; Joseph, David; Galvão, Daniel A. (Elsevier, 2021)Background Androgen deprivation therapy (ADT) contributes to lean mass loss and adiposity increases in prostate cancer patients. Radiotherapy during ADT might act synergistically and further worsen body composition. ...
Supervised Physical Training Enhances Muscle Strength but Not Muscle Mass in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy : A Systematic Review and Meta-Analysis Chen, Ziyuan; Zhang, Yuan; Lu, Chunyan; Zeng, Hao; Schumann, Moritz; Cheng, Sulin (Frontiers Media, 2019)Introduction: Androgen deprivation therapy (ADT) is considered the basic treatment for advanced prostate cancer, but it is highly associated with detrimental changes in muscle mass and muscle strength. The aim of this ...
Does Use of Androgen Deprivation Therapy (ADT) in Men with Prostate Cancer Increase the Risk of Sarcopenia? Owen, Patrick J.; Daly, Robin M.; Dalla Via, Jack; Mundell, Niamh L.; Livingston, Patricia M.; Rantalainen, Timo; Fraser, Steve F. (Springer New York LLC, 2019)Androgen deprivation therapy (ADT) for prostate cancer (PCa) can compromise muscle health. Hence, we aimed to quantify the prevalence of sarcopenia (i.e., compromised lean mass, muscle strength, and physical function) in ...
Bone mineral density, structure, distribution and strength in men with prostate cancer treated with androgen deprivation therapy Via, Jack Dalla; Daly, Robin M.; Owen, Patrick J.; Mundell, Niamh L.; Rantalainen, Timo; Fraser, Steve F. (Elsevier Inc., 2019)Androgen deprivation therapy (ADT) improves survival in men with advanced prostate cancer (PCa), but has been associated with compromised skeletal health and increased fracture risk. However, limited previous research has ...
The clinical relevance of adiposity when assessing muscle health in men treated with androgen deprivation for prostate cancer Owen, Patrick J.; Daly, Robin M.; Via, Jack Dalla; Mundell, Niamh L.; Livingston, Patricia M.; Rantalainen, Timo; Fraser, Steve F. (Wiley - VCH Verlag GmbH & Co. KGaA, 2019)Background: Androgen deprivation therapy (ADT) for prostate cancer (PCa) may prospectively decrease absolute lean mass (LM) and increase absolute fat mass (FM). Given that estimates of LM by dual‐energy X‐ray absorptiometry ...