Inadequate oral anticoagulation with warfarin in women with cerebrovascular event and history of atrial fibrillation : the FibStroke study
Bah, A., Nuotio, I., Palomäki, A., Mustonen, P., Kiviniemi, T., Ylitalo, A., Hartikainen, P., Airaksinen, K. E. J., & Hartikainen, J. E. K. (2021). Inadequate oral anticoagulation with warfarin in women with cerebrovascular event and history of atrial fibrillation : the FibStroke study. Annals of Medicine, 53(1), 287-294. https://doi.org/10.1080/07853890.2021.1875499
Published inAnnals of Medicine
© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group
Background: Women with atrial fibrillation (AF) may be treated less actively with oral anticoagulation (OAC) than men. Patients and methods: We assessed sex differences in the implementation of stroke risk stratification with CHADS2 and CHA2DS2-VASc scores and reasons not to use OAC in 1747 AF patients suffering their first cerebrovascular event after the AF diagnosis. Results: Women were older and had more often a high stroke risk (CHADS2/CHA2DS2-VASc 2) than men (p < .001). On admission, 46.4% of women and 48.2% of men were on OAC with no sex difference (p ¼ .437). However, of patients without OAC, 74.4% of women and 49.5% of men should have been on OAC based on CHADS2/CHA2DS2-VASc 2 (p < .001). Conversely, 34.8% of men and 17.5% of women on OAC had a low or moderate risk (CHADS2/CHA2DS2-VASc 0–1, p < .001). A valid reason to omit OAC was reported in 38.6% of patients and less often in women (p < .001). Conclusions: OAC was underused in high-risk AF patients, particularly women, but prescribed often in men with low or moderate stroke risk. Reasons for omitting OAC treatment were poorly reported, particularly for women. ...
PublisherTaylor & Francis
ISSN Search the Publication Forum0785-3890
Publication in research information system
MetadataShow full item record
Additional information about fundingThis research is supported by The Finnish Foundation for Cardiovascular Research, Helsinki, Finland and the Clinical Research Fund (EVO) of Turku University Hospital, Turku, Finland.
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