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dc.contributor.authorLisko, Inna
dc.contributor.authorKulmala, Jenni
dc.contributor.authorAnnetorp, Martin
dc.contributor.authorNgandu, Tiia
dc.contributor.authorMangialasche, Francesca
dc.contributor.authorKivipelto, Miia
dc.date.accessioned2020-12-22T07:30:00Z
dc.date.available2020-12-22T07:30:00Z
dc.date.issued2021
dc.identifier.citationLisko, I., Kulmala, J., Annetorp, M., Ngandu, T., Mangialasche, F., & Kivipelto, M. (2021). How can dementia and disability be prevented in older adults : Where are we today and where are we going?. <i>Journal of Internal Medicine</i>, <i>289</i>(6), 807-830. <a href="https://doi.org/10.1111/joim.13227" target="_blank">https://doi.org/10.1111/joim.13227</a>
dc.identifier.otherCONVID_47397053
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/73372
dc.description.abstractAgeing of the population, together with population growth, has brought along an ample increase in the number of older individuals living with dementia and disabilities. Dementia is the main cause of disability in old age and promoting healthy brain ageing is considered as a key element in diminishing the burden of age‐related disabilities. The World Health Organization recently launched the first risk reduction guidelines for cognitive impairment and dementia. According to recent estimates approximately 40% of dementia cases worldwide could be attributable to 12 modifiable risk factors: low education; midlife hypertension and obesity; diabetes, smoking, excessive alcohol use, physical inactivity, depression, low social contact, hearing loss, traumatic brain injury and air pollution indicating clear prevention potential. Dementia and physical disability are closely linked with shared risk factors and possible shared underlying mechanisms supporting the possibility of integrated preventive interventions. FINGER trial was the first large randomized controlled trial indicting that multidomain lifestyle‐based intervention can prevent cognitive and functional decline among at risk older adults from the general population. Within the World‐Wide FINGERS network, the multidomain FINGER concept is now tested and adapted worldwide proving evidence and tools for effective and easily implementable preventive strategies. Close collaboration between researchers, policy makers, and health care practitioners, involvement of older adults and utilization of new technologies to support self‐management is needed to facilitate implementation of the research findings. In this scoping review, we present the current scientific evidence in the field of dementia and disability prevention and discuss future directions in the field.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofseriesJournal of Internal Medicine
dc.rightsCC BY 4.0
dc.subject.otherdementia
dc.subject.othercognitive impairment
dc.subject.othermuscle physiology
dc.subject.otherageing
dc.subject.otherprevention
dc.titleHow can dementia and disability be prevented in older adults : Where are we today and where are we going?
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202012227315
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.format.pagerange807-830
dc.relation.issn0954-6820
dc.relation.numberinseries6
dc.relation.volume289
dc.type.versionpublishedVersion
dc.rights.copyright© 2020 The Authors. Journal of Internal Medicine published by John Wiley & Sons Ltd on behalf of Association for Publication of The Journal of Internal Medicine.
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber334419
dc.subject.ysoikääntyminen
dc.subject.ysoliikuntarajoitteet
dc.subject.ysomuistisairaudet
dc.subject.ysoikääntyneet
dc.subject.ysodementia
dc.subject.ysotoimintakyky
dc.subject.ysoriskitekijät
dc.subject.ysoehkäisevä lääketiede
dc.subject.ysoliikuntakyky
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p5056
jyx.subject.urihttp://www.yso.fi/onto/yso/p27708
jyx.subject.urihttp://www.yso.fi/onto/yso/p22037
jyx.subject.urihttp://www.yso.fi/onto/yso/p2433
jyx.subject.urihttp://www.yso.fi/onto/yso/p1711
jyx.subject.urihttp://www.yso.fi/onto/yso/p10213
jyx.subject.urihttp://www.yso.fi/onto/yso/p13277
jyx.subject.urihttp://www.yso.fi/onto/yso/p17163
jyx.subject.urihttp://www.yso.fi/onto/yso/p22622
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1111/joim.13227
dc.relation.funderSuomen Akatemiafi
dc.relation.funderAcademy of Finlanden
jyx.fundingprogramTutkijatohtori, SAfi
jyx.fundingprogramPostdoctoral Researcher, AoFen
jyx.fundinginformationAcknowledgments This work was financially supported by Juho Vainio Foundation, Finnish Cultural Foundation, Yrjö Jahnsson Foundation, Alzheimer’s Research and Prevention Foundation, Jalmari and Rauha Ahokas Foundation; Academy of Finland (grant numbers 334419 and 317465); EURO-FINGERS, an EU Joint Programme - Neurodegenerative Disease Research (JPND) project (supported through the following funding organisations under the aegis of JPND - www.jpnd.eu Finland: Academy of Finland (grant number 334804); Sweden: Swedish Research Council (grant number 2019-02226); Alzheimerfonden Sweden, Knut and Alice Wallenberg Foundation; Center for Innovative Medicine (CIMED) at Karolinska Institutet, Sweden, Region Stockholm (ALF grant), Sweden; Stiftelsen Stockholms sjukhem, Konung Gustaf V:s och Drottning Victorias Frimurarstiftelse


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