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dc.contributor.authorSelenius, Jannica S.
dc.contributor.authorWasenius, Niko S.
dc.contributor.authorKautiainen, Hannu
dc.contributor.authorSalonen, Minna
dc.contributor.authorvon Bonsdorff, Mikaela
dc.contributor.authorEriksson, Johan G.
dc.date.accessioned2020-11-10T08:46:02Z
dc.date.available2020-11-10T08:46:02Z
dc.date.issued2020
dc.identifier.citationSelenius, J. S., Wasenius, N. S., Kautiainen, H., Salonen, M., von Bonsdorff, M., & Eriksson, J. G. (2020). Impaired glucose regulation, depressive symptoms, and health-related quality of life. <i>BMJ Open Diabetes Research and Care</i>, <i>8</i>, Article e001568. <a href="https://doi.org/10.1136/bmjdrc-2020-001568" target="_blank">https://doi.org/10.1136/bmjdrc-2020-001568</a>
dc.identifier.otherCONVID_43605670
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/72561
dc.description.abstractIntroduction: This study aims to investigate whether the associations between impaired glucose regulation and health-related quality of life are modified by severity or type of depressive symptoms. Research design and methods: For this cross-sectional study, we included 1939 individuals (mean age 61.5 years) from the Helsinki Birth Cohort Study. Between 2001 and 2004, a standard 2-hour 75 g oral glucose tolerance test was applied to define normoglycemia, pre-diabetes, and newly diagnosed diabetes. Information on previously diagnosed diabetes was collected from national registers and questionnaires. Pre-diabetes was defined as having either impaired fasting glucose or impaired glucose tolerance. The Mental and Physical Component Scores of health-related quality of life were assessed with Short Form-36. Beck's Depression Inventory was employed to investigate the severity of depressive symptoms and to define minimal (depression score <10), non-melancholic, and melancholic types of depression. We analyzed data with general linear models adjusted for sex, age, lifestyle factors, comorbidities, and body mass index. Results: Glucose regulation subgroups, especially previously known diabetes, were associated with lower Physical Component Score (p=0.001) and higher depression score (p=0.015), but not with the Mental Component Score (p=0.189). Non-melancholic depression was associated with lower Physical and Mental Component Scores compared with those with depression score <10 and melancholic depression (p<0.001), independently of glucose regulation status (p for glucose regulation status by depression type interaction >0.54). Conclusions: Non-melancholic type of depression and previously known diabetes are independently associated with lower health-related quality of life. This should be appraised in long-term treatment of diabetes and when treating non-melancholic depressive symptoms to maintain a higher health-related quality of life.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherBMJ Publishing Group Ltd
dc.relation.ispartofseriesBMJ Open Diabetes Research and Care
dc.rightsCC BY 4.0
dc.subject.otherdepression
dc.subject.otherdiabetes mellitus
dc.subject.otherinsulin resistance
dc.subject.otherquality of life
dc.subject.othertype 2
dc.titleImpaired glucose regulation, depressive symptoms, and health-related quality of life
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202011106599
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontologian tutkimuskeskusfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.contributor.oppiaineGerontology Research Centeren
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.relation.issn2052-4897
dc.relation.volume8
dc.type.versionpublishedVersion
dc.rights.copyright© 2020 the Authors
dc.rights.accesslevelopenAccessfi
dc.subject.ysoikääntyneet
dc.subject.ysofyysinen hyvinvointi
dc.subject.ysoinsuliiniresistenssi
dc.subject.ysoelämänlaatu
dc.subject.ysoaikuistyypin diabetes
dc.subject.ysokeski-ikäiset
dc.subject.ysohenkinen hyvinvointi
dc.subject.ysomasennus
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p2433
jyx.subject.urihttp://www.yso.fi/onto/yso/p38424
jyx.subject.urihttp://www.yso.fi/onto/yso/p22290
jyx.subject.urihttp://www.yso.fi/onto/yso/p10759
jyx.subject.urihttp://www.yso.fi/onto/yso/p8303
jyx.subject.urihttp://www.yso.fi/onto/yso/p11718
jyx.subject.urihttp://www.yso.fi/onto/yso/p1946
jyx.subject.urihttp://www.yso.fi/onto/yso/p7995
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1136/bmjdrc-2020-001568
jyx.fundinginformationHBCS was supported by Finnish Foundation for Cardiovascular Research, Finnish Foundation for Diabetes Research, Juho Vainio Foundation, Academy of Finland, Novo Nordisk Foundation, Signe and Ane Gyllenberg Foundation, Samfundet Folkhälsan, Finska Läkaresällskapet, Liv och Hälsa, European Commission FP7 (DORIAN) Grant Agreement No 278 603 and EU H2020-PHC-2014-DynaHealth Grant No 633 595 and EU Horizon 2020 Award 733 206 LIFECYCLE.


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