dc.contributor.author | Thapa, Chandan J. | |
dc.contributor.author | Haataja, Tatu | |
dc.contributor.author | Pentikäinen, Ulla | |
dc.contributor.author | Permi, Perttu | |
dc.date.accessioned | 2020-06-03T04:16:49Z | |
dc.date.available | 2020-06-03T04:16:49Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Thapa, C. J., Haataja, T., Pentikäinen, U., & Permi, P. (2020). 1H, 13C and 15N NMR chemical shift assignments of cAMP-regulated phosphoprotein-19 and -16 (ARPP-19 and ARPP-16). <i>Biomolecular NMR Assignments</i>, <i>14</i>(2), 227-231. <a href="https://doi.org/10.1007/s12104-020-09951-w" target="_blank">https://doi.org/10.1007/s12104-020-09951-w</a> | |
dc.identifier.other | CONVID_35788340 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/69659 | |
dc.description.abstract | Protein Phosphatase 2A, PP2A, the principal Serine/threonine phosphatase, has major roles in broad range of signaling pathways that include regulation of cell cycle, cell proliferation and neuronal signaling. The loss of function of PP2A is linked with many human diseases, like cancer and neurodegenerative disorders. Protein phosphatase 2A (PP2A) functions as tumor suppressor and its tumor suppressor activity is inhibited by the overexpression of PP2A inhibitor proteins in most of the cancers. ARPP-19/ARPP-16 has been identified as one of the potential PP2A inhibitor proteins. Here, we report the resonance assignment of backbone 1H, 13C and 15N atoms of human ARPP-19 and ARPP-16 proteins. These chemical shift values can provide valuable information for the further study of the dynamics and interaction of ARPP-proteins to PP2A using NMR spectroscopy. | en |
dc.format.mimetype | application/pdf | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | Springer | |
dc.relation.ispartofseries | Biomolecular NMR Assignments | |
dc.rights | CC BY 4.0 | |
dc.subject.other | assignments | |
dc.subject.other | cAMP-regulated phosphoprotein-19 | |
dc.subject.other | HA-detection, intrinsically disordered protein | |
dc.subject.other | NMR spectroscopy | |
dc.title | 1H, 13C and 15N NMR chemical shift assignments of cAMP-regulated phosphoprotein-19 and -16 (ARPP-19 and ARPP-16) | |
dc.type | research article | |
dc.identifier.urn | URN:NBN:fi:jyu-202006033917 | |
dc.contributor.laitos | Bio- ja ympäristötieteiden laitos | fi |
dc.contributor.laitos | Department of Biological and Environmental Science | en |
dc.contributor.oppiaine | Nanoscience Center | fi |
dc.contributor.oppiaine | Solu- ja molekyylibiologia | fi |
dc.contributor.oppiaine | Nanoscience Center | en |
dc.contributor.oppiaine | Cell and Molecular Biology | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
dc.description.reviewstatus | peerReviewed | |
dc.format.pagerange | 227-231 | |
dc.relation.issn | 1874-2718 | |
dc.relation.numberinseries | 2 | |
dc.relation.volume | 14 | |
dc.type.version | publishedVersion | |
dc.rights.copyright | © The Authors, 2020 | |
dc.rights.accesslevel | openAccess | fi |
dc.type.publication | article | |
dc.relation.grantnumber | 288235 | |
dc.subject.yso | entsyymit | |
dc.subject.yso | NMR-spektroskopia | |
dc.subject.yso | soluviestintä | |
dc.subject.yso | proteiinit | |
dc.format.content | fulltext | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p4769 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p26254 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p28740 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p4332 | |
dc.rights.url | https://creativecommons.org/licenses/by/4.0/ | |
dc.relation.doi | 10.1007/s12104-020-09951-w | |
dc.relation.funder | Research Council of Finland | en |
dc.relation.funder | Suomen Akatemia | fi |
jyx.fundingprogram | Academy Project, AoF | en |
jyx.fundingprogram | Akatemiahanke, SA | fi |
jyx.fundinginformation | Open access funding provided by University of Jyväskylä (JYU). This work is supported by grants from Academy of Finland (Number 288235 to PP and 28348 to UP). Chandan Thapa is a recipient of doctoral student scholarship from the University of Jyvaskyla Graduate School (JYUGS), Department of Biological and Environmental science, University of Jyvaskyla. | |
dc.type.okm | A1 | |