A hexavalent Coxsackievirus B vaccine is highly immunogenic and has a strong protective capacity in mice and nonhuman primates
Stone, V. M., Hankaniemi, M.M., Laitinen, O. H., Sioofy-Khojine, A. B., Lin, A., Diaz Lozano, I. M., Mazur, M. A., Marjomäki, V., Loré, K., Hyöty, H., Hytönen, V. P., & Flodström-Tullberg, M. (2020). A hexavalent Coxsackievirus B vaccine is highly immunogenic and has a strong protective capacity in mice and nonhuman primates. Science Advances, 6(19), Article eaaz2433. https://doi.org/10.1126/sciadv.aaz2433
Julkaistu sarjassa
Science AdvancesPäivämäärä
2020Tekijänoikeudet
© 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
Coxsackievirus B (CVB) enteroviruses are common human pathogens known to cause severe diseases including myocarditis, chronic dilated cardiomyopathy, and aseptic meningitis. CVBs are also hypothesized to be a causal factor in type 1 diabetes. Vaccines against CVBs are not currently available, and here we describe the generation and preclinical testing of a novel hexavalent vaccine targeting the six known CVB serotypes. We show that the vaccine has an excellent safety profile in murine models and nonhuman primates and that it induces strong neutralizing antibody responses to the six serotypes in both species without an adjuvant. We also demonstrate that the vaccine provides immunity against acute CVB infections in mice, including CVB infections known to cause virus-induced myocarditis. In addition, it blocks CVB-induced diabetes in a genetically permissive mouse model. Our preclinical proof-of-concept studies demonstrate the successful generation of a promising hexavalent CVB vaccine with high immunogenicity capable of preventing CVB-induced diseases.
...
![showless](/themes/JYX2//images/showless.png)
![showmore](/themes/JYX2//images/showmore.png)
Julkaisija
American Association for the Advancement of ScienceISSN Hae Julkaisufoorumista
2375-2548Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/35400162
Metadata
Näytä kaikki kuvailutiedotKokoelmat
Lisätietoja rahoituksesta
We would like to acknowledge the financial support from the Business Finland [formerly TEKES (THERDIAB project, diary no. 1843/31/2014)]; the Academy of Finland (grant nos. 288671 and 1309455); the Swedish Child Diabetes Foundation; and Karolinska Institutet including the Strategic Research Program in Diabetes.Lisenssi
Samankaltainen aineisto
Näytetään aineistoja, joilla on samankaltainen nimeke tai asiasanat.
-
A comparative study of the effect of UV and formalin inactivation on the stability and immunogenicity of a Coxsackievirus B1 vaccine
Hankaniemi, Minna M.; Stone, Virginia M.; Sioofy-Khojine, Amir-Babak; Heinimäki, Suvi; Marjomäki, Varpu; Hyöty, Heikki; Blazevic, Vesna; Laitinen, Olli H.; Flodström-Tullberg, Malin; Hytönen, Vesa P. (Elsevier Ltd, 2019)Type B Coxsackieviruses (CVBs) belong to the enterovirus genus, and they cause both acute and chronic diseases in humans. CVB infections usually lead to flu-like symptoms but can also result in more serious diseases such ... -
Formalin treatment increases the stability and immunogenicity of coxsackievirus B1 VLP vaccine
Hankaniemi, Minna M.; Stone, Virginia M.; Andrejeff, Tanja; Heinimäki, Suvi; Sioofy-Khojine, Amir-Babak; Marjomäki, Varpu; Hyöty, Heikki; Blazevic, Vesna; Flodström-Tullberg, Malin; Hytönen, Vesa P.; Laitinen, Olli H. (Elsevier, 2019)Type B Coxsackieviruses (CVBs) are a common cause of acute and chronic myocarditis, dilated cardiomyopathy and aseptic meningitis. However, no CVB-vaccines are available for human use. We have previously produced virus-like ... -
Structural Insight into CVB3-VLP Non-Adjuvanted Vaccine
Hankaniemi, Minna M.; Baikoghli, Mo A.; Stone, Virginia M.; Xing, Li; Väätäinen, Outi; Soppela, Saana; Sioofy-Khojine, Amirbabak; Saarinen, Niila V. V.; Ou, Tingwei; Anson, Brandon; Hyöty, Heikki; Marjomäki, Varpu; Flodström-Tullberg, Malin; Cheng, R. H.; Hytönen, Vesa P.; Laitinen, Olli H. (MDPI, 2020)Coxsackievirus B (CVB) enteroviruses are common pathogens that can cause acute and chronic myocarditis, dilated cardiomyopathy, aseptic meningitis, and they are hypothesized to be a causal factor in type 1 diabetes. The ... -
Detection of enterovirus infection in pancreas tissue
Runtuvuori, Anniina (2017)Coxsackievirusryhmä B (CVB) kuuluu Picornaviridae -heimoon ja Enterovirus-sukuun. Pikornavirukset ovat pieniä, halkaisijaltaan noin 30 nm, vaipattomia ja ikosahedraalisia viruksia. Viimeaikaiset tutkimukset ovat osoittaneet, ... -
Detecting Enterovirus Infection in Type 1 Diabetic Pancreas Tissue Using Immuno-Electron Microscopy
Lommi, Sara (2019)Tyypin 1 diabetes on krooninen autoimmuunisairaus, jossa kehon glukoositasapaino on häiriintynyt. Tautia sairastavan potilaan haiman beta-solut ovat tuhoutuneet, minkä takia insuliinia ei muodostu tarpeeksi kehon ...
Ellei toisin mainittu, julkisesti saatavilla olevia JYX-metatietoja (poislukien tiivistelmät) saa vapaasti uudelleenkäyttää CC0-lisenssillä.