A hexavalent Coxsackievirus B vaccine is highly immunogenic and has a strong protective capacity in mice and nonhuman primates
Stone, V. M., Hankaniemi, M.M., Laitinen, O. H., Sioofy-Khojine, A. B., Lin, A., Diaz Lozano, I. M., Mazur, M. A., Marjomäki, V., Loré, K., Hyöty, H., Hytönen, V. P., & Flodström-Tullberg, M. (2020). A hexavalent Coxsackievirus B vaccine is highly immunogenic and has a strong protective capacity in mice and nonhuman primates. Science Advances, 6(19), Article eaaz2433. https://doi.org/10.1126/sciadv.aaz2433
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2020Copyright
© 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
Coxsackievirus B (CVB) enteroviruses are common human pathogens known to cause severe diseases including myocarditis, chronic dilated cardiomyopathy, and aseptic meningitis. CVBs are also hypothesized to be a causal factor in type 1 diabetes. Vaccines against CVBs are not currently available, and here we describe the generation and preclinical testing of a novel hexavalent vaccine targeting the six known CVB serotypes. We show that the vaccine has an excellent safety profile in murine models and nonhuman primates and that it induces strong neutralizing antibody responses to the six serotypes in both species without an adjuvant. We also demonstrate that the vaccine provides immunity against acute CVB infections in mice, including CVB infections known to cause virus-induced myocarditis. In addition, it blocks CVB-induced diabetes in a genetically permissive mouse model. Our preclinical proof-of-concept studies demonstrate the successful generation of a promising hexavalent CVB vaccine with high immunogenicity capable of preventing CVB-induced diseases.
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American Association for the Advancement of ScienceISSN Search the Publication Forum
2375-2548Publication in research information system
https://converis.jyu.fi/converis/portal/detail/Publication/35400162
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We would like to acknowledge the financial support from the Business Finland [formerly TEKES (THERDIAB project, diary no. 1843/31/2014)]; the Academy of Finland (grant nos. 288671 and 1309455); the Swedish Child Diabetes Foundation; and Karolinska Institutet including the Strategic Research Program in Diabetes.License
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