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dc.contributor.authorRuohonen, Elisa M.
dc.contributor.authorKattainen, Saara
dc.contributor.authorLi, Xueqiao
dc.contributor.authorTaskila, Anna-Elisa
dc.contributor.authorYe, Chaoxiong
dc.contributor.authorAstikainen, Piia
dc.date.accessioned2020-04-07T06:45:40Z
dc.date.available2020-04-07T06:45:40Z
dc.date.issued2020
dc.identifier.citationRuohonen, E. M., Kattainen, S., Li, X., Taskila, A.-E., Ye, C., & Astikainen, P. (2020). Event-Related Potentials to Changes in Sound Intensity Demonstrate Alterations in Brain Function Related to Depression and Aging. <i>Frontiers in Human Neuroscience</i>, <i>14</i>, Article 98. <a href="https://doi.org/10.3389/fnhum.2020.00098" target="_blank">https://doi.org/10.3389/fnhum.2020.00098</a>
dc.identifier.otherCONVID_35177989
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/68472
dc.description.abstractMeasures of the brain’s automatic electrophysiological responses to sounds represent a potential tool for identifying age- and depression-related neural markers. However, these markers have rarely been studied related to aging and depression within one study. Here, we investigated auditory event-related potentials (ERPs) in the brain that may show different alterations related to aging and depression. We used an oddball condition employing changes in sound intensity to investigate: (i) sound intensity dependence; (ii) sensory gating; and (iii) change detection, all within a single paradigm. The ERPs of younger (18–40 years) and older (62–80 years) depressed female participants and age-matched non-depressed participants were measured. Intensity dependence was examined as the difference between N1 responses to repeated high- and low-intensity sounds, sensory gating as N1 responses to rare and repeated sounds, and change detection as indexed by the mismatch negativity (MMN). We found that intensity dependence was greater in older participants than younger ones, indicating effects related to aging but not to depression. For sensory gating, we found depression- and age-related alterations as increased N1 responses. No group differences were found for MMN. Although a sensory gating deficit was expected in older adults, this study is the first to demonstrate age-related overexcitability in sound intensity dependency. The results indicate that automatic brain responses to sound intensity changes are suitable for studying age- and depression-related neural markers but may not be sensitive enough to differentiate the effects of aging and depression.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherFrontiers Media
dc.relation.ispartofseriesFrontiers in Human Neuroscience
dc.rightsCC BY 4.0
dc.subject.otheraging
dc.subject.otherauditory-evoked potentials
dc.subject.otherdepression
dc.subject.otherintensity dependence
dc.subject.othersensory gating
dc.titleEvent-Related Potentials to Changes in Sound Intensity Demonstrate Alterations in Brain Function Related to Depression and Aging
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202004072687
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.oppiainePsykologiafi
dc.contributor.oppiaineMonitieteinen aivotutkimuskeskusfi
dc.contributor.oppiainePsychologyen
dc.contributor.oppiaineCentre for Interdisciplinary Brain Researchen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.relation.issn1662-5161
dc.relation.volume14
dc.type.versionpublishedVersion
dc.rights.copyright© 2020 The Author(s)
dc.rights.accesslevelopenAccessfi
dc.subject.ysomasennus
dc.subject.ysoikääntyminen
dc.subject.ysoneuropsykologia
dc.subject.ysokuulo
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p7995
jyx.subject.urihttp://www.yso.fi/onto/yso/p5056
jyx.subject.urihttp://www.yso.fi/onto/yso/p14664
jyx.subject.urihttp://www.yso.fi/onto/yso/p1937
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.3389/fnhum.2020.00098
jyx.fundinginformationThis work was supported by the Finnish Cultural foundation (Suomen Kulttuurirahasto, personal grants to ER: grant numbers 00150811, 00180941 and 00190910). The University of Jyväskylä provided funding for the open access publication fee.


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