dc.contributor.author | Mustalahti, Satu | |
dc.contributor.author | Morozov, Dmitry | |
dc.contributor.author | Luk, Hoi Ling | |
dc.contributor.author | Pallerla, Rajanish R. | |
dc.contributor.author | Myllyperkiö, Pasi | |
dc.contributor.author | Pettersson, Mika | |
dc.contributor.author | Pihko, Petri M. | |
dc.contributor.author | Groenhof, Gerrit | |
dc.date.accessioned | 2020-03-02T08:10:02Z | |
dc.date.available | 2020-03-02T08:10:02Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Mustalahti, S., Morozov, D., Luk, H. L., Pallerla, R. R., Myllyperkiö, P., Pettersson, M., Pihko, P. M., & Groenhof, G. (2020). Photoactive Yellow Protein Chromophore Photoisomerizes around a Single Bond if the Double Bond Is Locked. <i>Journal of Physical Chemistry Letters</i>, <i>11</i>(6), 2177-2181. <a href="https://doi.org/10.1021/acs.jpclett.0c00060" target="_blank">https://doi.org/10.1021/acs.jpclett.0c00060</a> | |
dc.identifier.other | CONVID_34774627 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/68018 | |
dc.description.abstract | Photoactivation in the Photoactive Yellow Protein, a bacterial blue light photoreceptor, proceeds via photo-isomerization of the double C=C bond in the covalently attached chromophore. Quantum chemistry calculations, however, have suggested that in addition to double bond photo-isomerization, the isolated chromophore and many of its analogues, can isomerize around a single C-C bond as well. Whereas double bond photo-isomerization has been observed with x-ray crystallography, experimental evidence for single bond photo-isomerization is currently lacking. Therefore, we have synthesized a chromophore analogue, in which the formal double bond is covalently locked in a cyclopentenone ring and carried out transient absorption spectroscopy experiments in combination with non-adiabatic molecular dynamics simulations to reveal that the locked chromophore isomerizes around the single bond upon photo-activation. Our work thus provides experimental evidence for single bond photo-isomerization in a photoactive yellow protein chromophore analogue and suggests that photo-isomerization is not restricted to the double bonds in conjugated systems. This insight may be useful for designing light-driven molecular switches or motors. | en |
dc.format.mimetype | application/pdf | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | American Chemical Society | |
dc.relation.ispartofseries | Journal of Physical Chemistry Letters | |
dc.rights | CC BY 4.0 | |
dc.subject.other | photoactivation | |
dc.subject.other | photo-isomerization | |
dc.subject.other | photoactive yellow protein | |
dc.subject.other | single bond | |
dc.subject.other | double bond | |
dc.title | Photoactive Yellow Protein Chromophore Photoisomerizes around a Single Bond if the Double Bond Is Locked | |
dc.type | article | |
dc.identifier.urn | URN:NBN:fi:jyu-202003022240 | |
dc.contributor.laitos | Kemian laitos | fi |
dc.contributor.laitos | Matemaattis-luonnontieteellinen tiedekunta | fi |
dc.contributor.laitos | Department of Chemistry | en |
dc.contributor.laitos | Faculty of Mathematics and Science | en |
dc.contributor.oppiaine | Orgaaninen kemia | fi |
dc.contributor.oppiaine | Fysikaalinen kemia | fi |
dc.contributor.oppiaine | Organic Chemistry | en |
dc.contributor.oppiaine | Physical Chemistry | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
dc.description.reviewstatus | peerReviewed | |
dc.format.pagerange | 2177-2181 | |
dc.relation.issn | 1948-7185 | |
dc.relation.numberinseries | 6 | |
dc.relation.volume | 11 | |
dc.type.version | acceptedVersion | |
dc.rights.copyright | © 2020 American Chemical Society | |
dc.rights.accesslevel | openAccess | fi |
dc.relation.grantnumber | 823830 | |
dc.relation.grantnumber | 823830 | |
dc.relation.grantnumber | 304455 | |
dc.relation.grantnumber | 297874 | |
dc.relation.grantnumber | 290677 | |
dc.relation.projectid | info:eu-repo/grantAgreement/EC/H2020/823830/EU//BioExcel-2 | |
dc.subject.yso | valokemia | |
dc.subject.yso | isomeria | |
dc.subject.yso | kemialliset sidokset | |
dc.subject.yso | proteiinit | |
dc.format.content | fulltext | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p7201 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p10129 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p10130 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p4332 | |
dc.rights.url | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.relation.doi | 10.1021/acs.jpclett.0c00060 | |
dc.relation.funder | European Commission | en |
dc.relation.funder | Research Council of Finland | en |
dc.relation.funder | Research Council of Finland | en |
dc.relation.funder | Research Council of Finland | en |
dc.relation.funder | Euroopan komissio | fi |
dc.relation.funder | Suomen Akatemia | fi |
dc.relation.funder | Suomen Akatemia | fi |
dc.relation.funder | Suomen Akatemia | fi |
jyx.fundingprogram | Research infrastructures, H2020 | en |
jyx.fundingprogram | Others, AoF | en |
jyx.fundingprogram | Academy Project, AoF | en |
jyx.fundingprogram | Academy Project, AoF | en |
jyx.fundingprogram | Research infrastructures, H2020 | fi |
jyx.fundingprogram | Muut, SA | fi |
jyx.fundingprogram | Akatemiahanke, SA | fi |
jyx.fundingprogram | Akatemiahanke, SA | fi |
jyx.fundinginformation | This work has been done as part of the BioExcel CoE (www.bioexcel.eu), a project funded by the European Union contracts H2020-INFRAEDI-02-2018-823830, H2020-EINFRA-2015-1-675728. In addition, we received funding from the Academy of Finland (Grants 297874, 290677 and 304455). | |
dc.type.okm | A1 | |