Physical Activity Predicts Population-Level Age-Related Differences in Frontal White Matter
Strömmer, J., Davis, S. W., Henson, R. N., Tyler, L. K., Consortium, C. C. F. A. A. N., & Campbell, K. L. (2020). Physical Activity Predicts Population-Level Age-Related Differences in Frontal White Matter. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 75(2), 236-243. https://doi.org/10.1093/gerona/gly220
© 2018 the Author(s)
Physical activity has positive effects on brain health and cognitive function throughout the life span. Thus far, few studies have examined the effects of physical activity on white matter microstructure and psychomotor speed within the same, population-based sample (critical if conclusions are to extend to the wider population). Here, using diffusion tensor imaging and a simple reaction time task within a relatively large population-derived sample (N = 399; 18–87 years) from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN), we demonstrate that physical activity mediates the effect of age on white matter integrity, measured with fractional anisotropy. Higher self-reported daily physical activity was associated with greater preservation of white matter in several frontal tracts, including the genu of corpus callosum, uncinate fasciculus, external capsule, and anterior limb of the internal capsule. We also show that the age-related slowing is mediated by white matter integrity in the genu. Our findings contribute to a growing body of work, suggesting that a physically active lifestyle may protect against age-related structural disconnection and slowing. ...
PublisherOxford University Press; The Gerontological Society of America
Publication in research information system
MetadataShow full item record
Additional information about fundingThis work was supported by the Biotechnology and Biological Sciences Research Council (grant number BB/H008217/1).
Showing items with similar title or keywords.
Age-Related Declines in Lower Limb Muscle Function are Similar in Power and Endurance Athletes of Both Sexes : A Longitudinal Study of Master Athletes Ireland, Alex; Mittag, Uwe; Degens, Hans; Felsenberg, Dieter; Heinonen, Ari; Koltai, Erika; Korhonen, Marko T.; McPhee, Jamie S.; Mekjavic, Igor; Pisot, Rado; Rawer, Rainer; Radak, Zsolt; Simunic, Bostjan; Suominen, Harri; Rittweger, Jörn (Springer, 2021)The age-related decline in muscle function, particularly muscle power, is associated with increased risk of important clinical outcomes. Physical activity is an important determinant of muscle function, and different types ...
Rantakokko, Merja; Mänty, Minna; Rantanen, Taina (American College of Sports Medicine, 2013)Mobility is important for community independence. With increasing age, underlying pathologies, genetic vulnerabilities, physiological and sensory impairments, and environmental barriers increase the risk for mobility ...
Strömmer, Juho (University of Jyväskylä, 2018)Normal ageing is accompanied by profound changes in brain structure and declines in the automatic processing of sensory stimuli, which in turn lead to altered cognitive performance. However, behaviour and lifestyle ...
Relationships of leisure-time physical activity and work ability between different occupational physical demands in adult working men Päivärinne, Ville; Kautiainen, Hannu; Heinonen, Ari; Kiviranta, Ilkka (Springer, 2019)Purpose: Leisure-time physical activity (LTPA) is known to be associated with positive health benefits, but the role of occupational physical demands remains inconsistent. The purpose of the current study was to assess ...
Perceived Opportunities for Physical Activity and Willingness to Be More Active in Older Adults with Different Physical Activity Levels Aartolahti, Eeva; Eronen, Johanna; Törmäkangas, Timo; Rantanen, Taina; Hirvensalo, Mirja; Palmberg, Lotta; Skantz, Heidi; Viljanen, Anne; Portegijs, Erja; Iwarsson, Susanne; Rantakokko, Merja (MDPI AG, 2021)This study examined equity in physical activity (PA) by investigating whether perceived opportunity for PA was associated with willingness to be more active. Among community residents (75, 80, or 85 years old, n = 962) ...