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dc.contributor.authorStrömmer, Juho
dc.contributor.authorDavis, Simon W.
dc.contributor.authorHenson, Richard N.
dc.contributor.authorTyler, Lorraine K.
dc.contributor.authorConsortium, Cambridge Centre for Ageing and Neuroscience
dc.contributor.authorCampbell, Karen L.
dc.date.accessioned2020-02-05T07:15:28Z
dc.date.available2020-02-05T07:15:28Z
dc.date.issued2020
dc.identifier.citationStrömmer, J., Davis, S. W., Henson, R. N., Tyler, L. K., Consortium, C. C. F. A. A. N., & Campbell, K. L. (2020). Physical Activity Predicts Population-Level Age-Related Differences in Frontal White Matter. <i>Journals of Gerontology Series A: Biological Sciences and Medical Sciences</i>, <i>75</i>(2), 236-243. <a href="https://doi.org/10.1093/gerona/gly220" target="_blank">https://doi.org/10.1093/gerona/gly220</a>
dc.identifier.otherCONVID_28662518
dc.identifier.otherTUTKAID_79151
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/67740
dc.description.abstractPhysical activity has positive effects on brain health and cognitive function throughout the life span. Thus far, few studies have examined the effects of physical activity on white matter microstructure and psychomotor speed within the same, population-based sample (critical if conclusions are to extend to the wider population). Here, using diffusion tensor imaging and a simple reaction time task within a relatively large population-derived sample (N = 399; 18–87 years) from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN), we demonstrate that physical activity mediates the effect of age on white matter integrity, measured with fractional anisotropy. Higher self-reported daily physical activity was associated with greater preservation of white matter in several frontal tracts, including the genu of corpus callosum, uncinate fasciculus, external capsule, and anterior limb of the internal capsule. We also show that the age-related slowing is mediated by white matter integrity in the genu. Our findings contribute to a growing body of work, suggesting that a physically active lifestyle may protect against age-related structural disconnection and slowing.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherOxford University Press; The Gerontological Society of America
dc.relation.ispartofseriesJournals of Gerontology Series A: Biological Sciences and Medical Sciences
dc.rightsCC BY 4.0
dc.subject.otherbrain aging
dc.subject.otherexercise
dc.subject.othercognitive decline
dc.titlePhysical Activity Predicts Population-Level Age-Related Differences in Frontal White Matter
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202002031951
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.oppiainePsykologiafi
dc.contributor.oppiainePsychologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2020-02-03T04:15:42Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange236-243
dc.relation.issn1079-5006
dc.relation.numberinseries2
dc.relation.volume75
dc.type.versionpublishedVersion
dc.rights.copyright© 2018 the Author(s)
dc.rights.accesslevelopenAccessfi
dc.subject.ysoaivot
dc.subject.ysoikääntyminen
dc.subject.ysofyysinen aktiivisuus
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p7040
jyx.subject.urihttp://www.yso.fi/onto/yso/p5056
jyx.subject.urihttp://www.yso.fi/onto/yso/p23102
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1093/gerona/gly220
jyx.fundinginformationThis work was supported by the Biotechnology and Biological Sciences Research Council (grant number BB/H008217/1).


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Except where otherwise noted, this item's license is described as CC BY 4.0