Performance of Finnish biobanks in nationwide pulmonary carcinoid tumour research
Vesterinen, T., Salmenkivi, K., Mustonen, H., Kuopio, T., Lappi-Blanco, E., Paavonen, T., Vainio, P., Knuuttila, A., Carpén, O., Haglund, C., & Arola, J. (2020). Performance of Finnish biobanks in nationwide pulmonary carcinoid tumour research. Virchows Archiv, 476(2), 273-283. https://doi.org/10.1007/s00428-019-02625-6
Published inVirchows Archiv
© 2019 the Author(s)
Finnish hospital-integrated biobanks administer millions of formalin-fixed paraffin-embedded tissue samples collected within the clinical diagnostics. According to the Finnish Biobank Act, these samples can be coupled with patients’ clinical follow-up data and the data retrieved from national health registries. We collected a nationwide pulmonary carcinoid tumour series from Finnish biobanks to study prognostic factors as well as to explore how the number of tumours found in the Finnish biobanks corresponds to the number of tumours registered by the Finnish Cancer Registry (FCR). Finnish biobanks identified 88% of the tumours registered by the FCR and were able to deliver 63%. The main reasons for lacking samples were paucity of resected primary tumour tissue, incompatible primary diagnosis, and the absence of tissue blocks in the archives. The main bottleneck in the sample application process was retrieving patient data. Altogether, we received 224 tumour samples with appropriate patient data and identified six prognostic factors for shorter disease-specific survival: age over 56 years at the time of diagnosis, tumour size over 2.5 cm, atypical histology, Ki-67 proliferation index higher than 2.5%, hilar/mediastinal lymph node involvement at the time of diagnosis, and the presence of metastatic disease. In conclusion, the Finnish biobank infrastructure offers excellent opportunities for tissue-based research. However, to be able to develop the biobank operations further, involving more medical knowledge in the sample and data acquisition process is a necessity. Also, when working with tissue samples collected over decades, histological expertise is essential for re-evaluation and re-classification of the samples. ...
Publication in research information system
MetadataShow full item record
Additional information about fundingOpen access funding provided by University of Helsinki including Helsinki University Central Hospital. This study was funded by the Finnish Cancer Foundation (no grant number) and the Helsinki University Hospital Research Fund (grant number TYH2017204).
Showing items with similar title or keywords.
Prognostic impact of CD73 expression and its relationship to PD-L1 in patients with radically treated pancreatic cancer Tahkola, Kyösti; Ahtiainen, Maarit; Kellokumpu, Ilmo; Mecklin, Jukka-Pekka; Laukkarinen Johanna; Laakkonen, Joni; Kenessey, Istvan; Jalkanen, Sirpa; Salmi, Marko; Böhm, Jan (Springer, 2021)Immune suppressing molecule CD73 is overexpressed in various cancers and associated with poor survival. Little is so far known about the predictive value of CD73 in pancreatic ductal adenocarcinoma (PDAC). The purpose of ...
The expression and prognostic relevance of programmed cell death protein 1 in tongue squamous cell carcinoma Tervo, Sanni; Seppälä, Miia; Rautiainen, Markus; Huhtala, Heini; Salo, Tuula; Al‐Samadi, Ahmed; Kuopio, Teijo; Ahtiainen, Maarit; Tommola, Satu; Paavonen, Timo; Toppila‐Salmi, Sanna (Wiley-Blackwell, 2020)Background Programmed cell death protein 1 (PD‐1) is an immune checkpoint receptor which plays an important role in a patient´s immune responses to microbial and cancer antigens. It is expressed in tumor infiltrating ...
IGF2BP3 Associates with Proliferative Phenotype and Prognostic Features in B-Cell Acute Lymphoblastic Leukemia Mäkinen, Artturi; Nikkilä, Atte; Haapaniemi, Teppo; Oksa, Laura; Mehtonen, Juha; Vänskä, Matti; Heinäniemi, Merja; Paavonen, Timo; Lohi, Olli (MDPI, 2021)The oncofetal protein insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) belongs to a family of RNA-binding proteins involved in localization, stability, and translational regulation of target RNAs. IGF2BP3 is ...
Cohort differences in maximal physical performance : a comparison of 75- and 80-year-old men and women born 28 years apart Koivunen, Kaisa; Sillanpää, Elina; Munukka, Matti; Portegijs, Erja; Rantanen, Taina (Oxford University Press (OUP), 2021)Whether increased life expectancy is accompanied by increased functional capacity in older people at specific ages is unclear. We compared similar validated measures of maximal physical performance in two population-based ...
The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution Ballhausen, Alexej; Przybilla, Moritz Jakob; Jendrusch, Michael; Haupt, Saskia; Pfaffendorf, Elisabeth; Seidler, Florian; Witt, Johannes; Hernandez, Sanchez Alejandro; Urban, Katharina; Draxlbauer, Markus; Krausert, Sonja; Ahadova, Aysel; Kalteis, Martin Simon; Pfuderer, Pauline L.; Heid, Daniel; Stichel, Damian; Gebert, Johannes; Bonsack, Maria; Schott, Sarah; Bläker, Hendrik; Seppälä, Toni; Mecklin, Jukka-Pekka; Ten, Broeke Sanne; Nielsen, Maartje; Heuveline, Vincent; Krzykalla, Julia; Benner, Axel; Riemer, Angelika Beate; von Knebel Doeberitz, Magnus; Kloor, Matthias (Nature Publishing Group, 2020)The immune system can recognize and attack cancer cells, especially those with a high load of mutation-induced neoantigens. Such neoantigens are abundant in DNA mismatch repair (MMR)-deficient, microsatellite-unstable (MSI) ...