Fat oxidation at rest and during exercise in male monozygotic twins
Karppinen, J. E., Rottensteiner, M., Wiklund, P., Hämäläinen, K., Laakkonen, E. K., Kaprio, J., Kainulainen, H., & Kujala, U. M. (2019). Fat oxidation at rest and during exercise in male monozygotic twins. European Journal of Applied Physiology, 119(11-12), 2711-2722. https://doi.org/10.1007/s00421-019-04247-x
Published inEuropean Journal of Applied Physiology
DisciplineLiikuntafysiologiaGerontologia ja kansanterveysLiikuntalääketiedeExercise PhysiologyGerontology and Public HealthSports and Exercise Medicine
© The Author(s) 2019
Purpose. We aimed to investigate if hereditary factors, leisure-time physical activity (LTPA) and metabolic health interact with resting fat oxidation (RFO) and peak fat oxidation (PFO) during ergometer cycling. Methods. We recruited 23 male monozygotic twin pairs (aged 32–37 years) and determined their RFO and PFO with indirect calorimetry for 21 and 19 twin pairs and for 43 and 41 twin individuals, respectively. Using physical activity interviews and the Baecke questionnaire, we identified 10 twin pairs as LTPA discordant for the past 3 years. Of the twin pairs, 8 pairs participated in both RFO and PFO measurements, and 2 pairs participated in either of the measurements. We quantified the participants’ metabolic health with a 2-h oral glucose tolerance test. Results. Fat oxidation within co-twins was correlated at rest [intraclass correlation coefficient (ICC) = 0.54, 95% confidence interval (CI) 0.15–0.78] and during exercise (ICC = 0.67, 95% CI 0.33–0.86). The LTPA-discordant pairs had no pairwise differences in RFO or PFO. In the twin individual-based analysis, PFO was positively correlated with the past 12-month LTPA (r = 0.26, p = 0.034) and the Baecke score (r = 0.40, p = 0.022) and negatively correlated with the area under the curve of insulin (r = − 0.42, p = 0.015) and glucose (r = − 0.31, p = 0.050) during the oral glucose tolerance test. Conclusions. Hereditary factors were more important than LTPA for determining fat oxidation at rest and during exercise. Additionally, PFO, but not RFO, was associated with better metabolic health. ...
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Additional information about fundingThe FITFATTWIN study was supported by the Finnish Ministry of Education and Culture (OKM/56/626/2013 to UMK), META-PREDICT (within the European Union Seventh Framework Programme, HEALTH-F2-2012–277936 to UMK). Data collection for the FT16 study was supported by the National Institute of Alcohol Abuse and Alcoholism (grants AA-12502, AA-00145, and AA-09203 to RJ Rose) and the Academy of Finland (grants 100499, 205585, 118555, 141054, 264146, 308248 and 312073 to JK). ...
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