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dc.contributor.authorMäättä, Sara
dc.contributor.authorSäisänen, Laura
dc.contributor.authorKallioniemi, Elisa
dc.contributor.authorLakka, Timo A.
dc.contributor.authorLintu, Niina
dc.contributor.authorHaapala, Eero
dc.contributor.authorKoskenkorva, Päivi
dc.contributor.authorNiskanen, Eini
dc.contributor.authorFerreri, Florinda
dc.contributor.authorKönönen, Mervi
dc.date.accessioned2019-10-23T09:15:12Z
dc.date.available2020-01-15T22:35:28Z
dc.date.issued2019fi
dc.identifier.citationMäättä, S., Säisänen, L., Kallioniemi, E., Lakka, T. A., Lintu, N., Haapala, E., . . . Könönen, M. (2019). Maturation changes the excitability and effective connectivity of the frontal lobe : A developmental TMS-EEG study. <em>Human Brain Mapping</em>, 40 (8), 2320-2335. <a href="https://doi.org/10.1002/hbm.24525">doi:10.1002/hbm.24525</a>fi
dc.identifier.otherTUTKAID_80387
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/66002
dc.description.abstractThe combination of transcranial magnetic stimulation with simultaneous electroencephalography (TMS–EEG) offers direct neurophysiological insight into excitability and connectivity within neural circuits. However, there have been few developmental TMS–EEG studies to date, and they all have focused on primary motor cortex stimulation. In the present study, we used navigated high‐density TMS–EEG to investigate the maturation of the superior frontal cortex (dorsal premotor cortex [PMd]), which is involved in a broad range of motor and cognitive functions known to develop with age. We demonstrated that reactivity to frontal cortex TMS decreases with development. We also showed that although frontal cortex TMS elicits an equally complex TEP waveform in all age groups, the statistically significant between‐group differences in the topography of the TMS‐evoked peaks and differences in current density maps suggest changes in effective connectivity of the right PMd with maturation. More generally, our results indicate that direct study of the brain's excitability and effective connectivity via TMS–EEG co‐registration can also be applied to pediatric populations outside the primary motor cortex, and may provide useful information for developmental studies and studies on developmental neuropsychiatric disorders.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherJohn Wiley & Sons, Inc.
dc.relation.ispartofseriesHuman Brain Mapping
dc.rightsIn Copyright
dc.subject.othernuoretfi
dc.subject.otheraikuisetfi
dc.subject.otherlapsetfi
dc.subject.otheraivotfi
dc.subject.otheraivokuorifi
dc.subject.otherEEGfi
dc.subject.otherTMSfi
dc.subject.othermagneettistimulaatiofi
dc.subject.otheradolescentfi
dc.subject.otheradultfi
dc.subject.otherchildfi
dc.subject.otherconnectivityfi
dc.subject.otherelectroencephalographyfi
dc.subject.otherfrontal cortexfi
dc.subject.othertranscranial magnetic stimulationfi
dc.titleMaturation changes the excitability and effective connectivity of the frontal lobe : A developmental TMS-EEG studyfi
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201910214536
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineLiikuntalääketiede
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-10-21T12:15:10Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange2320-2335
dc.relation.issn1065-9471
dc.relation.numberinseries8
dc.relation.volume40
dc.type.versionacceptedVersion
dc.rights.copyright© 2019 Wiley Periodicals, Inc.
dc.rights.accesslevelopenAccessfi
dc.format.contentfulltext
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.doi10.1002/hbm.24525


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