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dc.contributor.authorMäättä, Sara
dc.contributor.authorSäisänen, Laura
dc.contributor.authorKallioniemi, Elisa
dc.contributor.authorLakka, Timo A.
dc.contributor.authorLintu, Niina
dc.contributor.authorHaapala, Eero
dc.contributor.authorKoskenkorva, Päivi
dc.contributor.authorNiskanen, Eini
dc.contributor.authorFerreri, Florinda
dc.contributor.authorKönönen, Mervi
dc.date.accessioned2019-10-23T09:15:12Z
dc.date.available2020-01-15T22:35:28Z
dc.date.issued2019
dc.identifier.citationMäättä, S., Säisänen, L., Kallioniemi, E., Lakka, T. A., Lintu, N., Haapala, E., Koskenkorva, P., Niskanen, E., Ferreri, F., & Könönen, M. (2019). Maturation changes the excitability and effective connectivity of the frontal lobe : A developmental TMS-EEG study. <i>Human Brain Mapping</i>, <i>40</i>(8), 2320-2335. <a href="https://doi.org/10.1002/hbm.24525" target="_blank">https://doi.org/10.1002/hbm.24525</a>
dc.identifier.otherCONVID_28872918
dc.identifier.otherTUTKAID_80387
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/66002
dc.description.abstractThe combination of transcranial magnetic stimulation with simultaneous electroencephalography (TMS–EEG) offers direct neurophysiological insight into excitability and connectivity within neural circuits. However, there have been few developmental TMS–EEG studies to date, and they all have focused on primary motor cortex stimulation. In the present study, we used navigated high‐density TMS–EEG to investigate the maturation of the superior frontal cortex (dorsal premotor cortex [PMd]), which is involved in a broad range of motor and cognitive functions known to develop with age. We demonstrated that reactivity to frontal cortex TMS decreases with development. We also showed that although frontal cortex TMS elicits an equally complex TEP waveform in all age groups, the statistically significant between‐group differences in the topography of the TMS‐evoked peaks and differences in current density maps suggest changes in effective connectivity of the right PMd with maturation. More generally, our results indicate that direct study of the brain's excitability and effective connectivity via TMS–EEG co‐registration can also be applied to pediatric populations outside the primary motor cortex, and may provide useful information for developmental studies and studies on developmental neuropsychiatric disorders.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherJohn Wiley & Sons, Inc.
dc.relation.ispartofseriesHuman Brain Mapping
dc.rightsIn Copyright
dc.subject.otherlapset
dc.subject.otherTMS
dc.subject.othermagneettistimulaatio
dc.subject.otheradolescent
dc.subject.otheradult
dc.subject.otherchild
dc.subject.otherconnectivity
dc.subject.otherelectroencephalography
dc.subject.otherfrontal cortex
dc.titleMaturation changes the excitability and effective connectivity of the frontal lobe : A developmental TMS-EEG study
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201910214536
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiaineSports and Exercise Medicineen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-10-21T12:15:10Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange2320-2335
dc.relation.issn1065-9471
dc.relation.numberinseries8
dc.relation.volume40
dc.type.versionacceptedVersion
dc.rights.copyright© 2019 Wiley Periodicals, Inc.
dc.rights.accesslevelopenAccessfi
dc.subject.ysonuoret
dc.subject.ysoaikuiset
dc.subject.ysoaivot
dc.subject.ysoaivokuori
dc.subject.ysoEEG
dc.subject.ysotranskraniaalinen magneettistimulaatio
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p11617
jyx.subject.urihttp://www.yso.fi/onto/yso/p5590
jyx.subject.urihttp://www.yso.fi/onto/yso/p7040
jyx.subject.urihttp://www.yso.fi/onto/yso/p7039
jyx.subject.urihttp://www.yso.fi/onto/yso/p3328
jyx.subject.urihttp://www.yso.fi/onto/yso/p26000
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.doi10.1002/hbm.24525
dc.type.okmA1


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