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dc.contributor.authorKunutsor, S.K.
dc.contributor.authorVoutilainen, A.
dc.contributor.authorWhitehouse, M.R.
dc.contributor.authorSeidu, S.
dc.contributor.authorKauhanen, J.
dc.contributor.authorBlom, A.W.
dc.contributor.authorLaukkanen, J.A.
dc.date.accessioned2019-10-15T11:12:35Z
dc.date.available2019-10-15T11:12:35Z
dc.date.issued2019
dc.identifier.citationKunutsor, S.K., Voutilainen, A., Whitehouse, M.R., Seidu, S., Kauhanen, J., Blom, A.W., & Laukkanen, J.A. (2019). Serum Albumin and Future Risk of Hip, Humeral, and Wrist Fractures in Caucasian Men : New Findings from a Prospective Cohort Study. <i>Medical Principles and Practice</i>, <i>28</i>(5), 401-409. <a href="https://doi.org/10.1159/000499738" target="_blank">https://doi.org/10.1159/000499738</a>
dc.identifier.otherCONVID_33239694
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/65889
dc.description.abstractObjective: Low serum albumin concentration is associated with poor health outcomes, but its relationship with the risk of fractures has not been reliably quantified. We aimed to assess the prospective association of serum albumin with the risk of fractures in a general population. Subjects and Methods: Baseline serum albumin concentrations were measured in 2,245 men aged 42–61 years in the Kuopio Is­chemic Heart Disease study. Hazard ratios (HRs) (95% confidence intervals) were calculated for incident fractures. Results: A total of 121 fractures (hip, humeral, or wrist) were recorded during a median follow-up of 25.6 years. The risk of fractures increased linearly below a serum albumin concentration of ∼48 g/L. The age-adjusted HR (95% CI) for fractures per 1 standard deviation lower serum albumin was 1.24 (1.05–1.48). On further adjustment for several conventional and emerging risk factors, the HR was attenuated to 1.21 (1.01–1.45). Comparing the bottom versus top quartile of serum albumin levels, the corresponding adjusted HRs were 2.48 (1.37–4.48) and 2.26 (1.23–4.14). The association of serum albumin with fracture risk did not differ substantially according to age, body mass index, blood pressure, physical activity, alcohol consumption, socioeconomic status, inflammation, prevalent diseases, and smoking. Serum albumin at a threshold of 41.5 g/L demonstrated an area under the curve of 0.5850. Conclusion: In middle-aged Caucasian men, low serum albumin is associated with an increased risk of future fractures. The potential relevance of serum albumin concentrations in fracture prevention and prediction deserves further evaluation.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherS. Karger
dc.relation.ispartofseriesMedical Principles and Practice
dc.rightsCC BY-NC 4.0
dc.subject.otherfracture
dc.subject.otherserum albumin
dc.titleSerum Albumin and Future Risk of Hip, Humeral, and Wrist Fractures in Caucasian Men : New Findings from a Prospective Cohort Study
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201910154468
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange401-409
dc.relation.issn1011-7571
dc.relation.numberinseries5
dc.relation.volume28
dc.type.versionpublishedVersion
dc.rights.copyright© 2019 The Authors. Published by S. Karger AG, Basel
dc.rights.accesslevelopenAccessfi
dc.subject.ysoluunmurtumat
dc.subject.ysoriskitekijät
dc.subject.ysobiomarkkerit
dc.subject.ysoalbumiinit
dc.subject.ysokohorttitutkimus
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p23619
jyx.subject.urihttp://www.yso.fi/onto/yso/p13277
jyx.subject.urihttp://www.yso.fi/onto/yso/p12288
jyx.subject.urihttp://www.yso.fi/onto/yso/p20319
jyx.subject.urihttp://www.yso.fi/onto/yso/p25606
dc.rights.urlhttps://creativecommons.org/licenses/by-nc/4.0/
dc.relation.doi10.1159/000499738
jyx.fundinginformationThis work was supported by the Finnish Foundation for Cardiovascular Research, Helsinki, Finland. Drs. Kunutsor, Whitehouse, and Blom acknowledge support from the NIHR Biomedical Research Centre at University Hospitals Bristol NHS Foundation Trust and the University of Bristol.
dc.type.okmA1


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