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dc.contributor.authorIsiozor, Nzechukwu M.
dc.contributor.authorKunutsor, Setor K.
dc.contributor.authorVoutilainen, Ari
dc.contributor.authorKurl, Sudhir
dc.contributor.authorKauhanen, Jussi
dc.contributor.authorLaukkanen, Jari A.
dc.date.accessioned2019-09-24T07:20:11Z
dc.date.available2019-09-24T07:20:11Z
dc.date.issued2019
dc.identifier.citationIsiozor, N. M., Kunutsor, S. K., Voutilainen, A., Kurl, S., Kauhanen, J., & Laukkanen, J. A. (2019). Ideal cardiovascular health and risk of acute myocardial infarction among Finnish men. <i>Atherosclerosis</i>, <i>289</i>, 126-131. <a href="https://doi.org/10.1016/j.atherosclerosis.2019.08.024" target="_blank">https://doi.org/10.1016/j.atherosclerosis.2019.08.024</a>
dc.identifier.otherCONVID_32703558
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/65624
dc.description.abstractBackground and aims: Acute myocardial infarction (AMI) is associated with high mortality globally and remains a public health burden. We sought to investigate the relation between the American Heart Association’s cardiovascular health metrics (CVH) and the risk of AMI among middle-aged Finnish men. Methods: We used the ongoing population-based Kuopio Ischaemic Heart Disease cohort study comprising men aged 40 to 62 years at baseline. The CVH metrics was computed among 2584 participants at baseline with health scores ranging from 0 to 7. This was categorized into three groups of CVH metrics as poor (0-2), intermediate (3-4) and ideal (≥5). Multivariate Cox regression models were used to estimate the hazard ratios (HR) and 95% confidence intervals (CIs) of CVH metrics for AMI. Results: During a median follow-up period of 25.2 years, 513 cases of AMI were recorded. Only one participant was able to achieve all the seven ideal health metrics. The risk of AMI decreased continuously with increasing number of CVH metrics across the range 2-7 (for non-linearity, p=0.07). Men with ideal CVH metrics had a HR (95% CI) for AMI of 0.28 (CI 0.15 – 0.55, p<0.001) compared to those with poor CVH metrics after adjustment for age, alcohol intake and socioeconomic status.The associations remained consistent following further adjustment for history of coronary heart disease and history of type 2 diabetes. Conclusions: Ideal CVH metrics was strongly and linearly associated with reduced risk of AMI among middle-aged Finnish men.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherElsevier Ireland Ltd.
dc.relation.ispartofseriesAtherosclerosis
dc.rightsCC BY-NC-ND 4.0
dc.subject.otheracute myocardial infarction
dc.subject.othercardiovascular health metrics
dc.subject.otherideal cardiovascular health
dc.subject.otherrisk factor
dc.subject.othermen
dc.titleIdeal cardiovascular health and risk of acute myocardial infarction among Finnish men
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201909244246
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiaineSports and Exercise Medicineen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.format.pagerange126-131
dc.relation.issn0021-9150
dc.relation.volume289
dc.type.versionacceptedVersion
dc.rights.copyright© 2019 Elsevier B.V.
dc.rights.accesslevelopenAccessfi
dc.subject.ysosydäninfarkti
dc.subject.ysomiehet
dc.subject.ysofyysinen kunto
dc.subject.ysoterveydentila
dc.subject.ysoriskitekijät
dc.subject.ysosydän- ja verisuonitaudit
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p8730
jyx.subject.urihttp://www.yso.fi/onto/yso/p8173
jyx.subject.urihttp://www.yso.fi/onto/yso/p7384
jyx.subject.urihttp://www.yso.fi/onto/yso/p11646
jyx.subject.urihttp://www.yso.fi/onto/yso/p13277
jyx.subject.urihttp://www.yso.fi/onto/yso/p9886
dc.rights.urlhttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.relation.doi10.1016/j.atherosclerosis.2019.08.024
jyx.fundinginformationThis study was supported in part by Matti and Vappu Maukonen grant for Heart Disease Research.


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