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dc.contributor.authorE, Repapi
dc.contributor.authorI, Sayers
dc.contributor.authorLV, Wain
dc.contributor.authorRB, Burton
dc.contributor.authorT, Johnson
dc.contributor.authorM, Obeidat
dc.contributor.authorJH, Zhao
dc.contributor.authorA, Ramasamy
dc.contributor.authorG, Zhai
dc.contributor.authorV, Vitart
dc.contributor.authorJE, Huffman
dc.contributor.authorW, Igl
dc.contributor.authorE, Albrecht
dc.contributor.authorP, Deloukas
dc.contributor.authorJ, Henderson
dc.contributor.authorJ, Granell
dc.contributor.authorWL, McArdle
dc.contributor.authorAR, Rudnicka
dc.contributor.authorConsortium, Wellcome Trust Case Control
dc.contributor.authorI, Barroso
dc.contributor.authorRJF, Loos
dc.contributor.authorNJ, Wareham
dc.contributor.authorL, Mustelin
dc.contributor.authorRantanen, Taina
dc.contributor.authorI, Surakka
dc.contributor.authorM, Imboden
dc.contributor.authorHE, Wichmann
dc.contributor.authorI, Grkovic
dc.contributor.authorS, Jankovic
dc.contributor.authorL, Zgaga
dc.contributor.authorA, Hartikainen
dc.contributor.authorL, Peltonen
dc.contributor.authorU, Gyllensten
dc.contributor.authorÅ, Johansson
dc.contributor.authorG, Zaboli
dc.contributor.authorH, Campbell
dc.contributor.authorSH, Wild
dc.contributor.authorJF, Wilson
dc.contributor.authorS, Gläser
dc.contributor.authorG, Homuth
dc.contributor.authorH, Völzke
dc.contributor.authorM, Mangino
dc.contributor.authorN, Soranzo
dc.contributor.authorTD, Spector
dc.contributor.authorO, Polašek
dc.contributor.authorI, Rudan
dc.contributor.authorAF, Wright
dc.contributor.authorM, Heliövaara
dc.contributor.authorS, Ripatti
dc.contributor.authorA, Pouta
dc.contributor.authorÅ, Torinsson Naluai
dc.contributor.authorA, Olin
dc.contributor.authorK, Torén
dc.contributor.authorMN, Cooper
dc.contributor.authorAL, James
dc.contributor.authorLJ, Palmer
dc.contributor.authorAD, Hingorani
dc.contributor.authorSG, Wannamethee
dc.contributor.authorPH, Whincup
dc.contributor.authorGD, Smith
dc.contributor.authorS, Ebrahim
dc.contributor.authorTM, McKeever
dc.contributor.authorID, Pavord
dc.contributor.authorAK, MacLeod
dc.contributor.authorAD, Morris
dc.contributor.authorDJ, Porteous
dc.contributor.authorC, Cooper
dc.contributor.authorE, Dennison
dc.contributor.authorS, Shaheen
dc.contributor.authorS, Karrasch
dc.contributor.authorE, Schnabel
dc.contributor.authorH, Schulz
dc.contributor.authorH, Grallert
dc.contributor.authorN, Bouatia-Naji
dc.contributor.authorJ, Delplanque
dc.contributor.authorP, Froguel
dc.contributor.authorJD, Blakey
dc.contributor.authorTeam, The NSHD Respiratory Study
dc.contributor.authorJR, Britton
dc.contributor.authorRW, Morris
dc.contributor.authorJW, Holloway
dc.contributor.authorDA, Lawlor
dc.contributor.authorJ, Hui
dc.contributor.authorF, Nyberg
dc.contributor.authorM, Jarvelin
dc.contributor.authorC, Jackson
dc.contributor.authorM, Kähönen
dc.contributor.authorJ, Kaprio
dc.contributor.authorNM, Probst-Hensch
dc.contributor.authorB, Koch
dc.contributor.authorC, Hayward
dc.contributor.authorDE, Evans
dc.contributor.authorP, Elliott
dc.contributor.authorDP, Strachan
dc.contributor.authorIP, Hall
dc.contributor.authorMD, Tobin
dc.date.accessioned2019-09-18T09:53:09Z
dc.date.available2019-09-18T09:53:09Z
dc.date.issued2010fi
dc.identifier.citationE, R., I, S., LV, W., RB, B., T, J., M, O., . . . MD, T. (2010). Genome-wide association study identifies five loci associated with lung function. <em>Nature Genetics</em>, 42 (1), 36-44. <a href="https://doi.org/10.1038/ng.501">https://doi.org/10.1038/ng.501</a>fi
dc.identifier.otherTUTKAID_45548
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/65547
dc.description.abstractPulmonary function measures are heritable traits that predict morbidity and mortality and define chronic obstructive pulmonary disease (COPD). We tested genome-wide association with forced expiratory volume in 1 s (FEV1) and the ratio of FEV1 to forced vital capacity (FVC) in the SpiroMeta consortium (n = 20,288 individuals of European ancestry). We conducted a meta-analysis of top signals with data from direct genotyping (n ≤ 32,184 additional individuals) and in silico summary association data from the CHARGE Consortium (n = 21,209) and the Health 2000 survey (n ≤ 883). We confirmed the reported locus at 4q31 and identified associations with FEV1 or FEV1/FVC and common variants at five additional loci: 2q35 in TNS1 (P = 1.11 × 10−12), 4q24 in GSTCD (2.18 × 10−23), 5q33 in HTR4 (P = 4.29 × 10−9), 6p21 in AGER (P = 3.07 × 10−15) and 15q23 in THSD4 (P = 7.24 × 10−15). mRNA analyses showed expression of TNS1, GSTCD, AGER, HTR4 and THSD4 in human lung tissue. These associations offer mechanistic insight into pulmonary function regulation and indicate potential targets for interventions to alleviate respiratory disease.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofseriesNature Genetics
dc.rightsIn Copyright
dc.subject.otherkeuhkotoiminnotfi
dc.subject.othergeenitfi
dc.subject.otherLung functionfi
dc.subject.othergeneticfi
dc.titleGenome-wide association study identifies five loci associated with lung functionfi
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201909184206
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveys
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-09-18T09:16:10Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange36-44
dc.relation.issn1061-4036
dc.relation.numberinseries1
dc.relation.volume42
dc.type.versionacceptedVersion
dc.rights.copyright© 2009, Springer Nature
dc.rights.accesslevelopenAccessfi
dc.format.contentfulltext
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en


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