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dc.contributor.authorRepapi, E.
dc.contributor.authorSayers, I.
dc.contributor.authorWain, LV.
dc.contributor.authorBurton, RB.
dc.contributor.authorJohnson, T.
dc.contributor.authorObeidat, M.
dc.contributor.authorZhao, JH.
dc.contributor.authorRamasamy, A.
dc.contributor.authorZhai, G.
dc.contributor.authorVitart, V.
dc.contributor.authorHuffman, JE.
dc.contributor.authorIgl, W.
dc.contributor.authorAlbrecht, E.
dc.contributor.authorDeloukas, P.
dc.contributor.authorHenderson, J.
dc.contributor.authorGranell, J.
dc.contributor.authorMcArdle, WL,.
dc.contributor.authorRudnicka, AR.
dc.contributor.authorConsortium, Wellcome Trust Case Control
dc.contributor.authorBarroso, I.
dc.contributor.authorLoos, RJF.
dc.contributor.authorWareham, NJ.
dc.contributor.authorMustelin, L.
dc.contributor.authorRantanen, Taina
dc.contributor.authorSurakka, I.
dc.contributor.authorImboden, M.
dc.contributor.authorWichmann, HE.
dc.contributor.authorGrkovic, I.
dc.contributor.authorJankovic, S.
dc.contributor.authorZgaga, L.
dc.contributor.authorHartikainen, A.
dc.contributor.authorPeltonen, L.
dc.contributor.authorGyllensten, U.
dc.contributor.authorJohansson, Å.
dc.contributor.authorZaboli, G.
dc.contributor.authorCampbell, H.
dc.contributor.authorWild, SH.
dc.contributor.authorWilson, JF.
dc.contributor.authorGläser, S.
dc.contributor.authorHomuth, G.
dc.contributor.authorVölzke, H.
dc.contributor.authorMangino, M.
dc.contributor.authorSoranzo, N.
dc.contributor.authorSpector, TD.
dc.contributor.authorPolašek, O,.
dc.contributor.authorRudan, I.
dc.contributor.authorWright, AF.
dc.contributor.authorHeliövaara, M.
dc.contributor.authorRipatti, S.
dc.contributor.authorPouta, A.
dc.contributor.authorTorinsson Naluai, Å.
dc.contributor.authorOlin, A.
dc.contributor.authorTorén, K.
dc.contributor.authorCooper, MN.
dc.contributor.authorJames, AL.
dc.contributor.authorPalmer, LJ.
dc.contributor.authorHingorani, AD.
dc.contributor.authorWannamethee, SG.
dc.contributor.authorWhincup, PH.
dc.contributor.authorSmith, GD.
dc.contributor.authorEbrahim, S.
dc.contributor.authorMcKeever, TM.
dc.contributor.authorPavord, ID.
dc.contributor.authorMacLeod, AK.
dc.contributor.authorMorris, AD.
dc.contributor.authorPorteous, DJ.
dc.contributor.authorCooper, C.
dc.contributor.authorDennison, E.
dc.contributor.authorShaheen, S.
dc.contributor.authorKarrasch, S.
dc.contributor.authorSchnabel, E.
dc.contributor.authorSchulz, H.
dc.contributor.authorGrallert, H.
dc.contributor.authorBouatia-Naji, N.
dc.contributor.authorDelplanque, J.
dc.contributor.authorFroguel, P.
dc.contributor.authorBlakey, JD.
dc.contributor.authorTeam, The NSHD Respiratory Study
dc.contributor.authorBritton, JR.
dc.contributor.authorMorris, RW.
dc.contributor.authorHolloway, JW.
dc.contributor.authorLawlor, DA.
dc.contributor.authorHui, J.
dc.contributor.authorNyberg, F.
dc.contributor.authorJarvelin, M.
dc.contributor.authorJackson, C.
dc.contributor.authorKähönen, M.
dc.contributor.authorKaprio, J.
dc.contributor.authorProbst-Hensch, NM.
dc.contributor.authorKoch, B.
dc.contributor.authorHayward, C.
dc.contributor.authorEvans, DE.
dc.contributor.authorElliott, P.
dc.contributor.authorStrachan, DP.
dc.contributor.authorHall, IP.
dc.contributor.authorTobin, MD.
dc.date.accessioned2019-09-18T09:53:09Z
dc.date.available2019-09-18T09:53:09Z
dc.date.issued2010
dc.identifier.citationE, R., I, S., LV, W., RB, B., T, J., M, O., JH, Z., A, R., G, Z., V, V., JE, H., W, I., E, A., P, D., J, H., J, G., WL, M., AR, R., Consortium, W. T. C. C., . . . MD, T. (2010). Genome-wide association study identifies five loci associated with lung function. <i>Nature Genetics</i>, <i>42</i>(1), 36-44. <a href="https://doi.org/10.1038/ng.501" target="_blank">https://doi.org/10.1038/ng.501</a>
dc.identifier.otherCONVID_20353560
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/65547
dc.description.abstractPulmonary function measures are heritable traits that predict morbidity and mortality and define chronic obstructive pulmonary disease (COPD). We tested genome-wide association with forced expiratory volume in 1 s (FEV1) and the ratio of FEV1 to forced vital capacity (FVC) in the SpiroMeta consortium (n = 20,288 individuals of European ancestry). We conducted a meta-analysis of top signals with data from direct genotyping (n ≤ 32,184 additional individuals) and in silico summary association data from the CHARGE Consortium (n = 21,209) and the Health 2000 survey (n ≤ 883). We confirmed the reported locus at 4q31 and identified associations with FEV1 or FEV1/FVC and common variants at five additional loci: 2q35 in TNS1 (P = 1.11 × 10−12), 4q24 in GSTCD (2.18 × 10−23), 5q33 in HTR4 (P = 4.29 × 10−9), 6p21 in AGER (P = 3.07 × 10−15) and 15q23 in THSD4 (P = 7.24 × 10−15). mRNA analyses showed expression of TNS1, GSTCD, AGER, HTR4 and THSD4 in human lung tissue. These associations offer mechanistic insight into pulmonary function regulation and indicate potential targets for interventions to alleviate respiratory disease.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofseriesNature Genetics
dc.rightsIn Copyright
dc.subject.otherkeuhkotoiminnot
dc.subject.otherLung function
dc.subject.othergenetic
dc.titleGenome-wide association study identifies five loci associated with lung function
dc.typeresearch article
dc.identifier.urnURN:NBN:fi:jyu-201909184206
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-09-18T09:16:10Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange36-44
dc.relation.issn1061-4036
dc.relation.numberinseries1
dc.relation.volume42
dc.type.versionacceptedVersion
dc.rights.copyright© 2009, Springer Nature
dc.rights.accesslevelopenAccessfi
dc.type.publicationarticle
dc.subject.ysogeenit
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p147
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.doi10.1038/ng.501
dc.type.okmA1


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