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dc.contributor.authorMäntyselkä A.
dc.contributor.authorHaapala E.A.
dc.contributor.authorLindi V.
dc.contributor.authorHäkkinen M.R.
dc.contributor.authorAuriola S
dc.contributor.authorJääskeläinen J.
dc.contributor.authorLakka T.A.
dc.date.accessioned2019-08-28T11:11:37Z
dc.date.available2019-08-28T11:11:37Z
dc.date.issued2019
dc.identifier.citationMäntyselkä A., Haapala E.A., Lindi V., Häkkinen M.R., Auriola S, Jääskeläinen J., Lakka T.A. (2019). Associations of IGF-1 and Adrenal Androgens with Cognition in Childhood. <i>Hormone Research in Paediatrics</i>, <i>91</i>(5), 329-335. <a href="https://doi.org/10.1159/000501719" target="_blank">https://doi.org/10.1159/000501719</a>
dc.identifier.otherCONVID_32474122
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/65348
dc.description.abstractBackground: Little is known about the association between adrenarche and cognition in general populations of children. We therefore studied the associations of dehydroepiandrosterone sulfate (DHEAS), androstenedione (A4), testosterone, insulin-like growth factor-1 (IGF-1), and adrenarche with cognition among prepubertal children. Methods: These cross-sectional analyses are based on baseline data of the Physical Activity and Nutrition in Children Study. A total of 387 children (183 girls, 204 boys) were included in the analyses. Raven’s Coloured Progressive Matrices (CPM) score was used to assess nonverbal reasoning. Serum adrenal androgens and IGF-1 concentrations were measured and clinical signs of androgen action were evaluated. Results: Higher IGF-1 among boys (β = 0.149, p =0.033) was related to a better Raven’s CPM score after adjustment for age and parental education. Adrenal androgens in girls or boys or IGF-1 in girls were not associated with the score. There were no differences in Raven’s CPM score between children with biochemical adrenarche (DHEAS ≥1.08 µmol/L; ≥40 µg/dL) or with clinical signs of androgen action and children without them. Conclusion: The results suggest that higher serum IGF-1 among boys is related to better cognition in prepubertal children. We could not provide evidence for the associations of adrenal maturation with cognition in prepubertal children.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherS. Karger
dc.relation.ispartofseriesHormone Research in Paediatrics
dc.rightsIn Copyright
dc.subject.otherDHEAS
dc.subject.otherinsulin-like growth factor-1
dc.subject.otheradrenarche
dc.subject.othercognition
dc.titleAssociations of IGF-1 and Adrenal Androgens with Cognition in Childhood
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201908283954
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiaineSports and Exercise Medicineen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.format.pagerange329-335
dc.relation.issn1663-2818
dc.relation.numberinseries5
dc.relation.volume91
dc.type.versionacceptedVersion
dc.rights.copyright© 2019 S. Karger AG, Basel.
dc.rights.accesslevelopenAccessfi
dc.subject.ysolapset (ikäryhmät)
dc.subject.ysoandrogeenit
dc.subject.ysosteroidit
dc.subject.ysokasvuhormonit
dc.subject.ysokognitio
dc.subject.ysokognitiivinen kehitys
dc.subject.ysohormonaaliset tekijät
dc.subject.ysoadrenarke
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p4354
jyx.subject.urihttp://www.yso.fi/onto/yso/p13606
jyx.subject.urihttp://www.yso.fi/onto/yso/p10983
jyx.subject.urihttp://www.yso.fi/onto/yso/p15759
jyx.subject.urihttp://www.yso.fi/onto/yso/p642
jyx.subject.urihttp://www.yso.fi/onto/yso/p15532
jyx.subject.urihttp://www.yso.fi/onto/yso/p21658
jyx.subject.urihttp://www.yso.fi/onto/yso/p23950
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.doi10.1159/000501719


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