Associations of IGF-1 and Adrenal Androgens with Cognition in Childhood
Mäntyselkä A., Haapala E.A., Lindi V., Häkkinen M.R., Auriola S, Jääskeläinen J., Lakka T.A. (2019). Associations of IGF-1 and Adrenal Androgens with Cognition in Childhood. Hormone Research in Paediatrics, 91(5), 329-335. https://doi.org/10.1159/000501719
Published inHormone Research in Paediatrics
Lindi V. |
© 2019 S. Karger AG, Basel.
Background: Little is known about the association between adrenarche and cognition in general populations of children. We therefore studied the associations of dehydroepiandrosterone sulfate (DHEAS), androstenedione (A4), testosterone, insulin-like growth factor-1 (IGF-1), and adrenarche with cognition among prepubertal children. Methods: These cross-sectional analyses are based on baseline data of the Physical Activity and Nutrition in Children Study. A total of 387 children (183 girls, 204 boys) were included in the analyses. Raven’s Coloured Progressive Matrices (CPM) score was used to assess nonverbal reasoning. Serum adrenal androgens and IGF-1 concentrations were measured and clinical signs of androgen action were evaluated. Results: Higher IGF-1 among boys (β = 0.149, p =0.033) was related to a better Raven’s CPM score after adjustment for age and parental education. Adrenal androgens in girls or boys or IGF-1 in girls were not associated with the score. There were no differences in Raven’s CPM score between children with biochemical adrenarche (DHEAS ≥1.08 µmol/L; ≥40 µg/dL) or with clinical signs of androgen action and children without them. Conclusion: The results suggest that higher serum IGF-1 among boys is related to better cognition in prepubertal children. We could not provide evidence for the associations of adrenal maturation with cognition in prepubertal children. ...
Publication in research information system
MetadataShow full item record
- Liikuntatieteiden tiedekunta 
Showing items with similar title or keywords.
Stodden, David; Lakes, Kimberley D.; Côté, Jean; Aadland, Eivind; Brian, Ali; Draper, Catherine E.; Ekkekakis, Panteleimon; Fumagalli, Guido; Laukkanen, Arto; Mavilidi, Myrto F.; Mazzoli, Emiliano; Neville, Ross D.; Niemistö, Donna; Rudd, James; Sääkslahti, Arja; Schmidt, Mirko; Tomporowski, Phillip D.; Tortella, Patrizia; Vazou, Spyridoula; Pesce, Caterina (Sociedade Brasileira de Comportamento Motor, 2021)
Laamanen, Petra; Kiuru, Noona; Flykt, Marjo; Vänskä, Mervi; Hietanen, Jari K.; Peltola, Mikko J.; Kurkela, Enni; Poikkeus, Piia; Tiitinen, Aila; Lindblom, Jallu (Wiley, 2022)Facial emotion recognition (FER) is a fundamental element in human interaction. It begins to develop soon after birth and is important in achieving developmental tasks of middle childhood, such as developing mutual friendships ...
An Overview on the Associations between Health Behaviors and Brain Health in Children and Adolescents with Special Reference to Diet Quality Naveed, Sehrish; Lakka, Timo; Haapala, Eero A. (MDPI, 2020)Unhealthy diet has been associated with overweight, obesity, increased cardiometabolic risk, and recently, to impaired cognition and academic performance. The aim of this review is to provide an overview of the associations ...
Sehrish, Naveed; Venäläinen, Taisa; Eloranta, Aino-Maija; Erkkilä, Arja T.; Jalkanen, Henna; Lindi, Virpi; Lakka, Timo A.; Haapala, Eero A. (Cambridge University Press, 2020)Objective: To investigate the cross-sectional associations of dietary carbohydrate and fatty acid intakes with cognition in mid-childhood. Design: Dietary carbohydrate and fatty acid intakes were assessed using 4-d ...
Vuoksimaa, Eero; Rose, Richard J.; Pulkkinen, Lea; Palviainen, Teemu; Rimfeld, Kaili; Lundström, Sebastian; Bartels, Meike; van Beijsterveldt, Catharina; Hendriks, Anne; de Zeeuw, Eveline L.; Plomin, Robert; Lichtenstein, Paul; Boomsma, Dorret I.; Kaprio, Jaakko (Wiley-Blackwell, 2021)Background To conduct a comprehensive assessment of the association between aggression and academic performance in compulsory education. Method We studied aggression and academic performance in over 27,000 individuals ...