dc.contributor.author | Mäntyselkä, A. | |
dc.contributor.author | Haapala, E.A. | |
dc.contributor.author | Lindi, V. | |
dc.contributor.author | Häkkinen, M.R. | |
dc.contributor.author | Auriola S | |
dc.contributor.author | Jääskeläinen, J. | |
dc.contributor.author | Lakka, T.A. | |
dc.date.accessioned | 2019-08-28T11:11:37Z | |
dc.date.available | 2019-08-28T11:11:37Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Mäntyselkä, A., Haapala, E.A., Lindi, V., Häkkinen, M.R., Auriola S, Jääskeläinen, J., Lakka, T.A. (2019). Associations of IGF-1 and Adrenal Androgens with Cognition in Childhood. <i>Hormone Research in Paediatrics</i>, <i>91</i>(5), 329-335. <a href="https://doi.org/10.1159/000501719" target="_blank">https://doi.org/10.1159/000501719</a> | |
dc.identifier.other | CONVID_32474122 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/65348 | |
dc.description.abstract | Background: Little is known about the association between adrenarche and cognition in general populations of children. We therefore studied the associations of dehydroepiandrosterone sulfate (DHEAS), androstenedione (A4), testosterone, insulin-like growth factor-1 (IGF-1), and adrenarche with cognition among prepubertal children. Methods: These cross-sectional analyses are based on baseline data of the Physical Activity and Nutrition in Children Study. A total of 387 children (183 girls, 204 boys) were included in the analyses. Raven’s Coloured Progressive Matrices (CPM) score was used to assess nonverbal reasoning. Serum adrenal androgens and IGF-1 concentrations were measured and clinical signs of androgen action were evaluated. Results: Higher IGF-1 among boys (β = 0.149, p =0.033) was related to a better Raven’s CPM score after adjustment for age and parental education. Adrenal androgens in girls or boys or IGF-1 in girls were not associated with the score. There were no differences in Raven’s CPM score between children with biochemical adrenarche (DHEAS ≥1.08 µmol/L; ≥40 µg/dL) or with clinical signs of androgen action and children without them. Conclusion: The results suggest that higher serum IGF-1 among boys is related to better cognition in prepubertal children. We could not provide evidence for the associations of adrenal maturation with cognition in prepubertal children. | en |
dc.format.mimetype | application/pdf | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | S. Karger | |
dc.relation.ispartofseries | Hormone Research in Paediatrics | |
dc.rights | In Copyright | |
dc.subject.other | DHEAS | |
dc.subject.other | insulin-like growth factor-1 | |
dc.subject.other | adrenarche | |
dc.subject.other | cognition | |
dc.title | Associations of IGF-1 and Adrenal Androgens with Cognition in Childhood | |
dc.type | article | |
dc.identifier.urn | URN:NBN:fi:jyu-201908283954 | |
dc.contributor.laitos | Liikuntatieteellinen tiedekunta | fi |
dc.contributor.laitos | Faculty of Sport and Health Sciences | en |
dc.contributor.oppiaine | Liikuntalääketiede | fi |
dc.contributor.oppiaine | Sports and Exercise Medicine | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
dc.description.reviewstatus | peerReviewed | |
dc.format.pagerange | 329-335 | |
dc.relation.issn | 1663-2818 | |
dc.relation.numberinseries | 5 | |
dc.relation.volume | 91 | |
dc.type.version | acceptedVersion | |
dc.rights.copyright | © 2019 S. Karger AG, Basel. | |
dc.rights.accesslevel | openAccess | fi |
dc.subject.yso | lapset (ikäryhmät) | |
dc.subject.yso | androgeenit | |
dc.subject.yso | steroidit | |
dc.subject.yso | kasvuhormonit | |
dc.subject.yso | kognitio | |
dc.subject.yso | kognitiivinen kehitys | |
dc.subject.yso | hormonaaliset tekijät | |
dc.subject.yso | adrenarke | |
dc.format.content | fulltext | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p4354 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p13606 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p10983 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p15759 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p642 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p15532 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p21658 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p23950 | |
dc.rights.url | http://rightsstatements.org/page/InC/1.0/?language=en | |
dc.relation.doi | 10.1159/000501719 | |
dc.type.okm | A1 | |