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dc.contributor.authorLipponen, Arto
dc.contributor.authorKurkela, Jari
dc.contributor.authorKyläheiko, I.
dc.contributor.authorHölttä, S.
dc.contributor.authorRuusuvirta, T.
dc.contributor.authorHämäläinen, Jarmo
dc.contributor.authorAstikainen, Piia
dc.date.accessioned2019-07-29T08:42:33Z
dc.date.available2020-01-29T22:35:46Z
dc.date.issued2019
dc.identifier.citationLipponen, A., Kurkela, J., Kyläheiko, I., Hölttä, S., Ruusuvirta, T., Hämäläinen, J., & Astikainen, P. (2019). Auditory-evoked potentials to changes in sound duration in urethane-anesthetized mice. <i>European Journal of Neuroscience</i>, <i>50</i>(2), 1911-1919. <a href="https://doi.org/10.1111/ejn.14359" target="_blank">https://doi.org/10.1111/ejn.14359</a>
dc.identifier.otherCONVID_28891338
dc.identifier.otherTUTKAID_80483
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/65135
dc.description.abstractSpectrotemporally complex sounds carry important information for acoustic communication. Among the important features of these sounds is the temporal duration. An event‐related potential called mismatch negativity indexes auditory change detection in humans. An analogous response (mismatch response) has been found to duration changes in speech sounds in rats but not yet in mice. We addressed whether mice show this response, and, if elicited, whether this response is functionally analogous to mismatch negativity or whether adaptation‐based models suffice to explain them. Auditory‐evoked potentials were epidurally recorded above the mice auditory cortex. The differential response to the changes in a repeated human speech sound /a/ was elicited 53–259 ms post‐change (oddball condition). The differential response was observable to the largest duration change (from 200 to 110 ms). Any smaller (from 200 to 120–180 ms at 10 ms steps) duration changes did elicit an observable response. The response to the largest duration change did not robustly differ in amplitude from the response to the change‐inducing sound presented without its repetitive background (equiprobable condition). The findings suggest that adaptation may suffice to explain responses to duration changes in spectrotemporally complex sounds in anaesthetized mice. The results pave way for development of a variety of murine models of acoustic communication.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing Ltd.
dc.relation.ispartofseriesEuropean Journal of Neuroscience
dc.rightsIn Copyright
dc.subject.otherAEPs
dc.subject.othermouse model
dc.subject.othertemporal feature
dc.titleAuditory-evoked potentials to changes in sound duration in urethane-anesthetized mice
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201907293689
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.oppiainePsykologiafi
dc.contributor.oppiainePsychologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-07-29T06:15:10Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1911-1919
dc.relation.issn0953-816X
dc.relation.numberinseries2
dc.relation.volume50
dc.type.versionacceptedVersion
dc.rights.copyright© 2019 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
dc.rights.accesslevelopenAccessfi
dc.subject.ysokuulohavainnot
dc.subject.ysopoikkeavuusnegatiivisuus
dc.subject.ysokoe-eläinmallit
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p23127
jyx.subject.urihttp://www.yso.fi/onto/yso/p26013
jyx.subject.urihttp://www.yso.fi/onto/yso/p28104
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.doi10.1111/ejn.14359
jyx.fundinginformationThis work was supported by the Academy of Finland, grant number 273134 to Piia Astikainen. The funding source was not involved in the study.


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