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dc.contributor.authorIjäs, Heini
dc.contributor.authorHakaste, Iiris
dc.contributor.authorShen, Boxuan
dc.contributor.authorKostiainen, Mauri A.
dc.contributor.authorLinko, Veikko
dc.date.accessioned2019-06-10T09:36:11Z
dc.date.available2019-06-10T09:36:11Z
dc.date.issued2019
dc.identifier.citationIjäs, H., Hakaste, I., Shen, B., Kostiainen, M. A., & Linko, V. (2019). Reconfigurable DNA Origami Nanocapsule for pH-Controlled Encapsulation and Display of Cargo. <i>ACS Nano</i>, <i>13</i>(5), 5959-5967. <a href="https://doi.org/10.1021/acsnano.9b01857" target="_blank">https://doi.org/10.1021/acsnano.9b01857</a>
dc.identifier.otherCONVID_30534247
dc.identifier.otherTUTKAID_81248
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/64477
dc.description.abstractDNA nanotechnology provides a toolbox for creating custom and precise nanostructures with nanometer-level accuracy. These nano-objects are often static by nature and serve as versatile templates for assembling various molecular components in a user-defined way. In addition to the static structures, the intrinsic programmability of DNA nanostructures allows the design of dynamic devices that can perform predefined tasks when triggered with external stimuli, such as drug delivery vehicles whose cargo display or release can be triggered with a specified physical or chemical cue in the biological environment. Here, we present a DNA origami nanocapsule that can be loaded with cargo and reversibly opened and closed by changing the pH of the surrounding solution. Moreover, the threshold pH value for opening/closing can be rationally designed. We characterize the reversible switching and a rapid opening of “pH-latch”-equipped nanocapsules using Förster resonance energy transfer. Furthermore, we demonstrate the full cycle of capsule loading, encapsulation, and displaying the payload using metal nanoparticles and functional enzymes as cargo mimics at physiologically relevant ion concentrations.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.ispartofseriesACS Nano
dc.rightsCC BY 4.0
dc.subject.otherDNA nanotechnology
dc.subject.otherDNA origami
dc.subject.otherdrug delivery
dc.subject.otherFörster resonance energy transfer
dc.subject.otherpH control
dc.titleReconfigurable DNA Origami Nanocapsule for pH-Controlled Encapsulation and Display of Cargo
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201906052969
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.contributor.oppiaineSolu- ja molekyylibiologiafi
dc.contributor.oppiaineNanoscience Centerfi
dc.contributor.oppiaineCell and Molecular Biologyen
dc.contributor.oppiaineNanoscience Centeren
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-06-05T09:15:10Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange5959-5967
dc.relation.issn1936-0851
dc.relation.numberinseries5
dc.relation.volume13
dc.type.versionpublishedVersion
dc.rights.copyright© 2019 American Chemical Society.
dc.rights.accesslevelopenAccessfi
dc.subject.ysoDNA
dc.subject.ysoentsyymit
dc.subject.ysonanohiukkaset
dc.subject.ysonanobiotekniikka
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p7690
jyx.subject.urihttp://www.yso.fi/onto/yso/p4769
jyx.subject.urihttp://www.yso.fi/onto/yso/p23451
jyx.subject.urihttp://www.yso.fi/onto/yso/p27775
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1021/acsnano.9b01857


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Except where otherwise noted, this item's license is described as CC BY 4.0