Näytä suppeat kuvailutiedot

dc.contributor.authorSarin, Heikki V.
dc.contributor.authorGudelj, Ivan
dc.contributor.authorHonkanen, Jarno
dc.contributor.authorIhalainen, Johanna
dc.contributor.authorVuorela, Arja
dc.contributor.authorLee, Joseph H.
dc.contributor.authorJin, Zhenzhen
dc.contributor.authorTerwilliger, Joseph D.
dc.contributor.authorIsola, Ville
dc.contributor.authorAhtiainen, Juha
dc.contributor.authorHäkkinen, Keijo
dc.contributor.authorJuric, Julija
dc.contributor.authorLauc, Gordan
dc.contributor.authorKristiansson, Kati
dc.contributor.authorHulmi, Juha
dc.contributor.authorPerola, Markus
dc.date.accessioned2019-05-31T08:53:16Z
dc.date.available2019-05-31T08:53:16Z
dc.date.issued2019
dc.identifier.citationSarin, H. V., Gudelj, I., Honkanen, J., Ihalainen, J., Vuorela, A., Lee, J. H., Jin, Z., Terwilliger, J. D., Isola, V., Ahtiainen, J., Häkkinen, K., Juric, J., Lauc, G., Kristiansson, K., Hulmi, J., & Perola, M. (2019). Molecular pathways mediating immunosuppression in response to prolonged intensive physical training, low-energy availability, and intensive weight loss. <i>Frontiers in Immunology</i>, <i>10</i>, Article 907. <a href="https://doi.org/10.3389/fimmu.2019.00907" target="_blank">https://doi.org/10.3389/fimmu.2019.00907</a>
dc.identifier.otherCONVID_30120236
dc.identifier.otherTUTKAID_81220
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/64282
dc.description.abstractExercise and exercise-induced weight loss have a beneficial effect on overall health, including positive effects on molecular pathways associated with immune function, especially in overweight individuals. The main aim of our study was to assess how energy deprivation (i.e., “semi-starvation”) leading to substantial fat mass loss affects the immune system and immunosuppression in previously normal weight individuals. Thus, to address this hypothesis, we applied a high-throughput systems biology approach to better characterize potential key pathways associated with immune system modulation during intensive weight loss and subsequent weight regain. We examined 42 healthy female physique athletes (age 27.5 ± 4.0 years, body mass index 23.4 ± 1.7 kg/m2) volunteered into either a diet group (n = 25) or a control group (n = 17). For the diet group, the energy intake was reduced and exercise levels were increased to induce loss of fat mass that was subsequently regained during a recovery period. The control group was instructed to maintain their typical lifestyle, exercise levels, and energy intake at a constant level. For quantification of systems biology markers, fasting blood samples were drawn at three time points: baseline (PRE), at the end of the weight loss period (MID 21.1 ± 3.1 weeks after PRE), and at the end of the weight regain period (POST 18.4 ± 2.9 weeks after MID). In contrast to the control group, the diet group showed significant (false discovery rate <0.05) alteration of all measured immune function parameters—white blood cells (WBCs), immunoglobulin G glycome, leukocyte transcriptome, and cytokine profile. Integrative omics suggested effects on multiple levels of immune system as dysregulated hematopoiesis, suppressed immune cell proliferation, attenuated systemic inflammation, and loss of immune cell function by reduced antibody and chemokine secretion was implied after intense weight loss. During the weight regain period, the majority of the measured immune system parameters returned back to the baseline. In summary, this study elucidated a number of molecular pathways presumably explaining immunosuppression in individuals going through prolonged periods of intense training with low-energy availability. Our findings also reinforce the perception that the way in which weight loss is achieved (i.e., dietary restriction, exercise, or both) has a distinct effect on how the immune system is modulated.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherFrontiers Research Foundation
dc.relation.ispartofseriesFrontiers in Immunology
dc.rightsCC BY 4.0
dc.subject.otherimmunosuppression
dc.subject.otherlow energy availability
dc.titleMolecular pathways mediating immunosuppression in response to prolonged intensive physical training, low-energy availability, and intensive weight loss
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201905062412
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineLiikuntafysiologiafi
dc.contributor.oppiaineValmennus- ja testausoppifi
dc.contributor.oppiaineExercise Physiologyen
dc.contributor.oppiaineScience of Sport Coaching and Fitness Testingen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-05-06T09:15:47Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn1664-3224
dc.relation.numberinseries0
dc.relation.volume10
dc.type.versionpublishedVersion
dc.rights.copyright© 2019 The Authors.
dc.rights.accesslevelopenAccessfi
dc.subject.ysoliikunta
dc.subject.ysobioinformatiikka
dc.subject.ysolaihdutus
dc.subject.ysoimmuunivaste
dc.subject.ysofyysinen aktiivisuus
dc.subject.ysoenergiansaanti
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p916
jyx.subject.urihttp://www.yso.fi/onto/yso/p15748
jyx.subject.urihttp://www.yso.fi/onto/yso/p825
jyx.subject.urihttp://www.yso.fi/onto/yso/p21599
jyx.subject.urihttp://www.yso.fi/onto/yso/p23102
jyx.subject.urihttp://www.yso.fi/onto/yso/p27286
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.3389/fimmu.2019.00907
dc.type.okmA1


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