Näytä suppeat kuvailutiedot

dc.contributor.authorGomez-Chamorro, Andrea
dc.contributor.authorBattilotti, Florian
dc.contributor.authorCayol, Claire
dc.contributor.authorMappes, Tapio
dc.contributor.authorKoskela, Esa
dc.contributor.authorBoulanger, Nathalie
dc.contributor.authorGenné, Dolores
dc.contributor.authorSarr, Anouk
dc.contributor.authorVoordouw, Maarten Jeroen
dc.date.accessioned2019-05-08T10:38:31Z
dc.date.available2019-05-08T10:38:31Z
dc.date.issued2019
dc.identifier.citationGomez-Chamorro, A., Battilotti, F., Cayol, C., Mappes, T., Koskela, E., Boulanger, N., Genné, D., Sarr, A., & Voordouw, M. J. (2019). Susceptibility to infection with Borrelia afzelii and TLR2 polymorphism in a wild reservoir host. <i>Scientific Reports</i>, <i>9</i>, Article 6711. <a href="https://doi.org/10.1038/s41598-019-43160-3" target="_blank">https://doi.org/10.1038/s41598-019-43160-3</a>
dc.identifier.otherCONVID_30606831
dc.identifier.otherTUTKAID_81334
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/63833
dc.description.abstractThe study of polymorphic immune genes in host populations is critical for understanding genetic variation in susceptibility to pathogens. Controlled infection experiments are necessary to separate variation in the probability of exposure from genetic variation in susceptibility to infection, but such experiments are rare for wild vertebrate reservoir hosts and their zoonotic pathogens. The bank vole (Myodes glareolus) is an important reservoir host of Borrelia afzelii, a tick-borne spirochete that causes Lyme disease. Bank vole populations are polymorphic for Toll-like receptor 2 (TLR2), an innate immune receptor that recognizes bacterial lipoproteins. To test whether the TLR2 polymorphism influences variation in the susceptibility to infection with B. afzelii, we challenged pathogen-free, lab-born individuals of known TLR2 genotype with B. afzelii-infected ticks. We measured the spirochete load in tissues of the bank voles. The susceptibility to infection with B. afzelii following an infected tick bite was very high (95%) and did not differ between TLR2 genotypes. The TLR2 polymorphism also had no effect on the spirochete abundance in the tissues of the bank voles. Under the laboratory conditions of our study, we did not find that the TLR2 polymorphism in bank voles influenced variation in the susceptibility to B. afzelii infection.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofseriesScientific Reports
dc.rightsCC BY 4.0
dc.subject.otherClethrionomys
dc.titleSusceptibility to infection with Borrelia afzelii and TLR2 polymorphism in a wild reservoir host
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201905062405
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.contributor.oppiaineEkologia ja evoluutiobiologiafi
dc.contributor.oppiaineEcology and Evolutionary Biologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-05-06T09:15:17Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn2045-2322
dc.relation.numberinseries0
dc.relation.volume9
dc.type.versionpublishedVersion
dc.rights.copyright© The Author(s) 2019
dc.rights.accesslevelopenAccessfi
dc.subject.ysoinfektiot
dc.subject.ysoBorrelia-bakteerit
dc.subject.ysoisäntäeläimet
dc.subject.ysoimmuniteetti
dc.subject.ysogenotyyppi
dc.subject.ysometsämyyrä
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p7316
jyx.subject.urihttp://www.yso.fi/onto/yso/p23656
jyx.subject.urihttp://www.yso.fi/onto/yso/p24487
jyx.subject.urihttp://www.yso.fi/onto/yso/p7524
jyx.subject.urihttp://www.yso.fi/onto/yso/p8863
jyx.subject.urihttp://www.yso.fi/onto/yso/p513
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1038/s41598-019-43160-3
dc.type.okmA1


Aineistoon kuuluvat tiedostot

Thumbnail

Aineisto kuuluu seuraaviin kokoelmiin

Näytä suppeat kuvailutiedot

CC BY 4.0
Ellei muuten mainita, aineiston lisenssi on CC BY 4.0