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dc.contributor.authorThiede, Anja
dc.contributor.authorVirtala, Paula
dc.contributor.authorAla-Kurikka, Iina
dc.contributor.authorPartanen, Eino
dc.contributor.authorHuotilainen, Minna
dc.contributor.authorMikkola, Kaija
dc.contributor.authorLeppänen, Paavo H.T.
dc.contributor.authorKujala, Teija
dc.date.accessioned2019-03-26T06:44:40Z
dc.date.available2020-06-01T21:35:14Z
dc.date.issued2019
dc.identifier.citationThiede, A., Virtala, P., Ala-Kurikka, I., Partanen, E., Huotilainen, M., Mikkola, K., Leppänen, P. H., & Kujala, T. (2019). An extensive pattern of atypical neural speech-sound discrimination in newborns at risk of dyslexia. <i>Clinical Neurophysiology</i>, <i>130</i>(5), 634-646. <a href="https://doi.org/10.1016/j.clinph.2019.01.019" target="_blank">https://doi.org/10.1016/j.clinph.2019.01.019</a>
dc.identifier.otherCONVID_28915209
dc.identifier.otherTUTKAID_80624
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/63273
dc.description.abstractObjective: Identifying early signs of developmental dyslexia, associated with deficient speech-sound processing, is paramount to establish early interventions. We aimed to find early speech-sound processing deficiencies in dyslexia, expecting diminished and atypically lateralized event-related potentials (ERP) and mismatch responses (MMR) in newborns at dyslexia risk. Methods: ERPs were recorded to a pseudoword and its variants (vowel-duration, vowel-identity, and syllable-frequency changes) from 88 newborns at high or no familial risk. The response significance was tested, and group, laterality, and frontality effects were assessed with repeated-measures ANOVA. Results: An early positive and right-lateralized ERP component was elicited by standard pseudowords in both groups, the response amplitude not differing between groups. Early negative MMRs were absent in the at-risk group, and MMRs to duration changes diminished compared to controls. MMRs to vowel changes had significant laterality x group interactions resulting from right-lateralized MMRs in controls. Conclusions: The MMRs of high-risk infants were absent or diminished, and morphologically atypical, suggesting atypical neural speech-sound discrimination. Significance: This atypical neural basis for speech discrimination may contribute to impaired language development, potentially leading to future reading problems.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherElsevier Ireland Ltd.
dc.relation.ispartofseriesClinical Neurophysiology
dc.rightsCC BY-NC-ND 4.0
dc.subject.othernewborn
dc.subject.othermismatch response (MMR)
dc.subject.otherevent-related potential (ERP)
dc.subject.otherauditory
dc.subject.otherspeech sound
dc.titleAn extensive pattern of atypical neural speech-sound discrimination in newborns at risk of dyslexia
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201903121837
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.oppiainePsykologiafi
dc.contributor.oppiainePsychologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-03-12T16:15:17Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange634-646
dc.relation.issn1388-2457
dc.relation.numberinseries5
dc.relation.volume130
dc.type.versionacceptedVersion
dc.rights.copyright© 2019 International Federation of Clinical Neurophysiology.
dc.rights.accesslevelopenAccessfi
dc.subject.ysovastasyntyneet
dc.subject.ysodysleksia
dc.subject.ysopuheääni
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p3525
jyx.subject.urihttp://www.yso.fi/onto/yso/p5303
jyx.subject.urihttp://www.yso.fi/onto/yso/p27936
dc.rights.urlhttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.relation.doi10.1016/j.clinph.2019.01.019


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