An extensive pattern of atypical neural speech-sound discrimination in newborns at risk of dyslexia
Thiede, A., Virtala, P., Ala-Kurikka, I., Partanen, E., Huotilainen, M., Mikkola, K., Leppänen, P. H., & Kujala, T. (2019). An extensive pattern of atypical neural speech-sound discrimination in newborns at risk of dyslexia. Clinical Neurophysiology, 130(5), 634-646. https://doi.org/10.1016/j.clinph.2019.01.019
Published inClinical Neurophysiology
© 2019 International Federation of Clinical Neurophysiology.
Objective: Identifying early signs of developmental dyslexia, associated with deficient speech-sound processing, is paramount to establish early interventions. We aimed to find early speech-sound processing deficiencies in dyslexia, expecting diminished and atypically lateralized event-related potentials (ERP) and mismatch responses (MMR) in newborns at dyslexia risk. Methods: ERPs were recorded to a pseudoword and its variants (vowel-duration, vowel-identity, and syllable-frequency changes) from 88 newborns at high or no familial risk. The response significance was tested, and group, laterality, and frontality effects were assessed with repeated-measures ANOVA. Results: An early positive and right-lateralized ERP component was elicited by standard pseudowords in both groups, the response amplitude not differing between groups. Early negative MMRs were absent in the at-risk group, and MMRs to duration changes diminished compared to controls. MMRs to vowel changes had significant laterality x group interactions resulting from right-lateralized MMRs in controls. Conclusions: The MMRs of high-risk infants were absent or diminished, and morphologically atypical, suggesting atypical neural speech-sound discrimination. Significance: This atypical neural basis for speech discrimination may contribute to impaired language development, potentially leading to future reading problems. ...
PublisherElsevier Ireland Ltd.
Publication in research information system
MetadataShow full item record
Showing items with similar title or keywords.
Brain responses to speech sounds in infants and children with and without familial risk for dyslexia Lohvansuu, Kaisa (University of Jyväskylä, 2015)Dyslexia, a specific reading disability, runs in families. Therefore, the risk for a child to become dyslexic increases multifold if reading difficulties occur in the family. One risk factor for dyslexia is a deficit in ...
Newborn brain responses measuring feature and change detection and predicting later language development in children with and without familial risk for dyslexia Guttorm, Tomi (Jyväskylän yliopisto, 2003)Lukemisen erityisvaikeuksia eli kehityksellistä dysleksiaa on noin 3-10 prosentilla suomalaisista koululaisista. Vaikeudet haittaavat eri tavoin heidän koulusuoriutumistaan ja vaikuttavat näin myös tulevaisuuden ...
Enhancement of brain event-related potentials to speech sounds is associated with compensated reading skills in dyslexic children with familial risk for dyslexia Lohvansuu, Kaisa; Hämäläinen, Jarmo; Tanskanen, Annika; Ervast, Leena; Heikkinen, Elisa; Lyytinen, Heikki; Leppänen, Paavo H.T. (Elsevier; International Organization of Psychophysiology, 2014)Specific reading disability, dyslexia, is a prevalent and heritable disorder impairing reading acquisition characterized by a phonological deficit. However, the underlying mechanism of how the impaired phonological processing ...
Event-related potentials to tones show differences between children with multiple risk factors for dyslexia and control children before the onset of formal reading instruction Hämäläinen, Jarmo; Lohvansuu, Kaisa; Ervast, Leena; Leppänen, Paavo H.T. (Elsevier BV; International Organization of Psychophysiology, 2015)Multiple risk factors can affect the development of specific reading problems or dyslexia. In addition to the most prevalent and studied risk factor, phonological processing, also auditory discrimination problems have ...
Virtala, Paula; Huotilainen, Minna; Partanen, Eino; Fellman, Vineta; Tervaniemi, Mari (Frontiers Research Foundation, 2013)Neural encoding of abstract rules in the audition of newborn infants has been recently demonstrated in several studies using event-related potentials (ERPs). In the present study the neural encoding of Western music chords ...