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dc.contributor.authorVinding, Mikkel C.
dc.contributor.authorTsitsi, Panagiota
dc.contributor.authorPiitulainen, Harri
dc.contributor.authorWaldthaler, Josefine
dc.contributor.authorJousmäki, Veikko
dc.contributor.authorIngvar, Martin
dc.contributor.authorSvenningsson, Per
dc.contributor.authorLundqvist, Daniel
dc.date.accessioned2019-03-15T08:36:32Z
dc.date.available2019-03-15T08:36:32Z
dc.date.issued2019fi
dc.identifier.citationVinding, M. C., Tsitsi, P., Piitulainen, H., Waldthaler, J., Jousmäki, V., Ingvar, M., . . . , & Lundqvist, D. (2019). Attenuated beta rebound to proprioceptive afferent feedback in Parkinson’s disease. <em>Scientific Reports</em>, 9, 2604. <a href="https://doi.org/10.1038/s41598-019-39204-3">doi:10.1038/s41598-019-39204-3</a>fi
dc.identifier.otherTUTKAID_80957
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/63140
dc.description.abstractMotor symptoms are defining traits in the diagnosis of Parkinson’s disease (PD). A crucial component in motor function is the integration of afferent proprioceptive sensory feedback. Previous studies have indicated abnormal movement-related cortical oscillatory activity in PD, but the role of the proprioceptive afference on abnormal oscillatory activity in PD has not been elucidated. We examine the cortical oscillations in the mu/beta-band (8–30 Hz) in the processing of proprioceptive stimulation in PD patients, ON/OFF levodopa medication, as compared to that of healthy controls (HC). We used a proprioceptive stimulator that generated precisely controlled passive movements of the index finger and measured the induced cortical oscillatory responses following the proprioceptive stimulation using magnetoencephalography. Both PD patients and HC showed a typical beta-band desynchronization during the passive movement. However, the subsequent beta rebound after the passive movement that was almost absent in PD patients compared to HC. Furthermore, we found no difference in the degree of beta rebound attenuation between patients ON and OFF levodopa medication. The results demonstrate a disease-related deterioration in cortical processing of proprioceptive afference in PD.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofseriesScientific Reports
dc.rightsCC BY 4.0
dc.subject.otheraivokuorifi
dc.subject.otherParkinsonin tautifi
dc.subject.othercortexfi
dc.subject.othermotor cortexfi
dc.subject.otherParkinson's diseasefi
dc.titleAttenuated beta rebound to proprioceptive afferent feedback in Parkinson’s diseasefi
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201903121831
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineLiikuntapsykologia
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-03-12T13:15:29Z
dc.description.reviewstatuspeerReviewed
dc.relation.issn2045-2322
dc.relation.numberinseries0
dc.relation.volume9
dc.type.versionpublishedVersion
dc.rights.copyright© The Author(s) 2019
dc.rights.accesslevelopenAccessfi
dc.format.contentfulltext
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1038/s41598-019-39204-3


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