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dc.contributor.authorZopf, David
dc.contributor.authorPittner, Angelina
dc.contributor.authorDathe, André
dc.contributor.authorGrosse, Norman
dc.contributor.authorCsáki, Andrea
dc.contributor.authorArstila, Kai
dc.contributor.authorToppari, Jussi
dc.contributor.authorSchott, Walter
dc.contributor.authorDontsov, Denis
dc.contributor.authorUhlrich, Günter
dc.contributor.authorFritzsche, Wolfgang
dc.contributor.authorStranik, Ondrej
dc.date.accessioned2019-02-22T13:31:32Z
dc.date.available2020-01-19T22:35:13Z
dc.date.issued2019
dc.identifier.citationZopf, D., Pittner, A., Dathe, A., Grosse, N., Csáki, A., Arstila, K., Toppari, J., Schott, W., Dontsov, D., Uhlrich, G., Fritzsche, W., & Stranik, O. (2019). Plasmonic nanosensor array for multiplexed DNA-based pathogen detection. <i>ACS Sensors</i>, <i>4</i>(2), 335-343. <a href="https://doi.org/10.1021/acssensors.8b01073" target="_blank">https://doi.org/10.1021/acssensors.8b01073</a>
dc.identifier.otherCONVID_28880712
dc.identifier.otherTUTKAID_80428
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/62938
dc.description.abstractIn this research we introduce a plasmonic nanoparticle based optical biosensor for monitoring of molecular binding events. The sensor utilizes spotted gold nanoparticle arrays as sensing platform. The nanoparticle spots are functionalized with capture DNA sequences complementary to the analyte (target) DNA. Upon incubation with the target sequence, it will bind on the respectively complementary functionalized particle spot. This binding changes the local refractive index, which is detected spectroscopically as the resulting changes of the localized surface plasmon resonance (LSPR) peak wavelength. In order to increase the signal, a small gold nanoparticle label is introduced. The binding can be reversed using chemical means (10 mM HCl). It is demonstrated that multiplexed detection and identification of several fungal pathogen DNA sequences subsequently on one sensor array are possible by this approach.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.ispartofseriesACS Sensors
dc.rightsIn Copyright
dc.subject.otherLSPR sensing
dc.subject.otherplasmonic nanoparticles
dc.subject.otherDNA detection
dc.subject.otherplasmonic array
dc.subject.otherFourier-transform-imaging spectroscopy
dc.titlePlasmonic nanosensor array for multiplexed DNA-based pathogen detection
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201902221623
dc.contributor.laitosFysiikan laitosfi
dc.contributor.laitosDepartment of Physicsen
dc.contributor.oppiaineFysiikkafi
dc.contributor.oppiaineNanoscience Centerfi
dc.contributor.oppiaineKiihdytinlaboratoriofi
dc.contributor.oppiainePhysicsen
dc.contributor.oppiaineNanoscience Centeren
dc.contributor.oppiaineAccelerator Laboratoryen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-02-22T13:15:23Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange335-343
dc.relation.issn2379-3694
dc.relation.numberinseries2
dc.relation.volume4
dc.type.versionacceptedVersion
dc.rights.copyright© 2019 American Chemical Society
dc.rights.accesslevelopenAccessfi
dc.subject.ysonanobiotekniikka
dc.subject.ysobiosensorit
dc.subject.ysonanohiukkaset
dc.subject.ysoDNA
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p27775
jyx.subject.urihttp://www.yso.fi/onto/yso/p22008
jyx.subject.urihttp://www.yso.fi/onto/yso/p23451
jyx.subject.urihttp://www.yso.fi/onto/yso/p7690
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.doi10.1021/acssensors.8b01073
dc.type.okmA1


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