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dc.contributor.authorAshrafi, Roghaieh
dc.contributor.authorBruneaux, Matthieu
dc.contributor.authorSundberg, Lotta-Riina
dc.contributor.authorPulkkinen, Katja
dc.contributor.authorValkonen, Janne
dc.contributor.authorKetola, Tarmo
dc.date.accessioned2018-10-31T10:40:34Z
dc.date.available2018-10-31T10:40:34Z
dc.date.issued2018
dc.identifier.citationAshrafi, R., Bruneaux, M., Sundberg, L.-R., Pulkkinen, K., Valkonen, J., & Ketola, T. (2018). Broad thermal tolerance is negatively correlated with virulence in an opportunistic bacterial pathogen. <i>Evolutionary Applications</i>, <i>11</i>(9), 1700-1714. <a href="https://doi.org/10.1111/eva.12673" target="_blank">https://doi.org/10.1111/eva.12673</a>
dc.identifier.otherCONVID_28141215
dc.identifier.otherTUTKAID_78135
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/60061
dc.description.abstractPredicting the effects of global increase in temperatures on disease virulence is challenging, especially for environmental opportunistic bacteria, because pathogen fitness may be differentially affected by temperature within and outside host environment. So far, there is very little empirical evidence on the connections between optimal temperature range and virulence in environmentally growing pathogens. Here, we explored whether the virulence of an environmentally growing opportunistic fish pathogen, Flavobacterium columnare, is malleable to evolutionary changes via correlated selection on thermal tolerance. To this end, we experimentally quantified the thermal performance curves (TPCs) for maximum biomass yield of 49 F. columnare isolates from eight different geographic locations in Finland over ten years (2003–2012). We also characterized virulence profiles of these strains in a zebra fish (Danio rerio) infection model. We show that virulence among the strains increased over the years, but thermal generalism, and in particular tolerance to higher temperatures, was negatively associated with virulence. Our data suggest that temperature has a strong effect on the pathogen genetic diversity and therefore presumably also on disease dynamics. However, the observed increase in frequency and severity of F. columnare epidemics over the last decade cannot be directly linked to bacterial evolution due to increased mean temperature, but is most likely associated with factors related to increased length of growing season, or other time‐dependent change in environment. Our study demonstrates that complex interactions between the host, the pathogen and the environment influence disease virulence of an environmentally growing opportunistic pathogen.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing, Inc.
dc.relation.ispartofseriesEvolutionary Applications
dc.rightsCC BY 4.0
dc.subject.otherthermal tolerance
dc.subject.otheropportunistic pathogen
dc.subject.otherthermal performance curves
dc.subject.otherclimate change
dc.titleBroad thermal tolerance is negatively correlated with virulence in an opportunistic bacterial pathogen
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201810164433
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.contributor.oppiaineEkologia ja evoluutiobiologiafi
dc.contributor.oppiaineSolu- ja molekyylibiologiafi
dc.contributor.oppiaineAkvaattiset tieteetfi
dc.contributor.oppiaineEcology and Evolutionary Biologyen
dc.contributor.oppiaineCell and Molecular Biologyen
dc.contributor.oppiaineAquatic Sciencesen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2018-10-16T09:15:14Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1700-1714
dc.relation.issn1752-4571
dc.relation.numberinseries9
dc.relation.volume11
dc.type.versionpublishedVersion
dc.rights.copyright© 2018 The Authors
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber278751
dc.relation.grantnumber304615
dc.relation.grantnumber266879
dc.subject.ysoilmastonmuutokset
dc.subject.ysobakteerit
dc.subject.ysolämmönsieto
dc.subject.ysotaudinaiheuttajat
dc.subject.ysovirulenssi
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p5729
jyx.subject.urihttp://www.yso.fi/onto/yso/p1749
jyx.subject.urihttp://www.yso.fi/onto/yso/p25351
jyx.subject.urihttp://www.yso.fi/onto/yso/p8822
jyx.subject.urihttp://www.yso.fi/onto/yso/p28481
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.datasethttps://doi.org/10.5061/dryad.858j5m7
dc.relation.doi10.1111/eva.12673
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderAcademy of Finlanden
dc.relation.funderAcademy of Finlanden
dc.relation.funderAcademy of Finlanden
jyx.fundingprogramAkatemiatutkijan tehtävä, SAfi
jyx.fundingprogramMuut, SAfi
jyx.fundingprogramAkatemiatutkijan tehtävä, SAfi
jyx.fundingprogramResearch post as Academy Research Fellow, AoFen
jyx.fundingprogramOthers, AoFen
jyx.fundingprogramResearch post as Academy Research Fellow, AoFen
jyx.fundinginformationThis work was supported by KONE Foundation (Roghaieh Ashrafi via project “Constraints of evolutionary adaptation to climate change” to Tarmo Ketola), OLVI Foundation (Roghaieh Ashrafi #201620393), the Jane and Aatos Erkko Foundation (Lotta‐Riina Sundberg), Finnish Cultural Foundation (Katja Pulkkinen) and Academy of Finland (Lotta‐Riina Sundberg # 266879 and # 304615, Tarmo Ketola # 278751, Jouni Taskinen # 260704 to Katja Pulkkinen) and Centre of Excellence in Biological Interactions (# 252411, Prof. Johanna Mappes) to Roghaieh Ashrafi, Lotta‐Riina Sundberg and Tarmo Ketola.


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