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dc.contributor.authorCairns, Johannes
dc.contributor.authorKoskinen, Katariina
dc.contributor.authorPenttinen, Reetta
dc.contributor.authorPatinen, Tommi
dc.contributor.authorHartikainen, Anna
dc.contributor.authorJokela, Roosa
dc.contributor.authorRuusulehto, Liisa
dc.contributor.authorViitamäki, Sirja
dc.contributor.authorMattila, Sari
dc.contributor.authorHiltunen, Teppo
dc.contributor.authorJalasvuori, Matti
dc.date.accessioned2018-10-30T11:41:45Z
dc.date.available2018-10-30T11:41:45Z
dc.date.issued2018
dc.identifier.citationCairns, J., Koskinen, K., Penttinen, R., Patinen, T., Hartikainen, A., Jokela, R., Ruusulehto, L., Viitamäki, S., Mattila, S., Hiltunen, T., & Jalasvuori, M. (2018). Black Queen Evolution and Trophic Interactions Determine Plasmid Survival after the Disruption of the Conjugation Network. <i>mSystems</i>, <i>3</i>(5), Article 00104-18. <a href="https://doi.org/10.1128/mSystems.00104-18" target="_blank">https://doi.org/10.1128/mSystems.00104-18</a>
dc.identifier.otherCONVID_28677432
dc.identifier.otherTUTKAID_79245
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/60036
dc.description.abstractMobile genetic elements such as conjugative plasmids are responsible for antibiotic resistance phenotypes in many bacterial pathogens. The ability to conjugate, the presence of antibiotics, and ecological interactions all have a notable role in the persistence of plasmids in bacterial populations. Here, we set out to investigate the contribution of these factors when the conjugation network was disturbed by a plasmid-dependent bacteriophage. Phage alone effectively caused the population to lose plasmids, thus rendering them susceptible to antibiotics. Leakiness of the antibiotic resistance mechanism allowing Black Queen evolution (i.e. a “race to the bottom”) was a more significant factor than the antibiotic concentration (lethal vs sublethal) in determining plasmid prevalence. Interestingly, plasmid loss was also prevented by protozoan predation. These results show that outcomes of attempts to resensitize bacterial communities by disrupting the conjugation network are highly dependent on ecological factors and resistance mechanisms.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherAmerican Society for Microbiology
dc.relation.ispartofseriesmSystems
dc.rightsCC BY 4.0
dc.subject.otherBlack Queen evolution
dc.subject.otherconjugation
dc.subject.othertrophic levels
dc.titleBlack Queen Evolution and Trophic Interactions Determine Plasmid Survival after the Disruption of the Conjugation Network
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201810234490
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.contributor.oppiaineSolu- ja molekyylibiologiafi
dc.contributor.oppiaineBiologisten vuorovaikutusten huippututkimusyksikköfi
dc.contributor.oppiaineNanoscience Centerfi
dc.contributor.oppiaineCell and Molecular Biologyen
dc.contributor.oppiaineCentre of Excellence in Biological Interactions Researchen
dc.contributor.oppiaineNanoscience Centeren
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2018-10-23T09:15:24Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn2379-5077
dc.relation.numberinseries5
dc.relation.volume3
dc.type.versionpublishedVersion
dc.rights.copyright© 2018 the Authors
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber297049
dc.subject.ysosaalistus
dc.subject.ysohorisontaalinen geeninsiirto
dc.subject.ysoantibioottiresistenssi
dc.subject.ysobakteerit
dc.subject.ysoplasmidit
dc.subject.ysoevoluutio
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p946
jyx.subject.urihttp://www.yso.fi/onto/yso/p29551
jyx.subject.urihttp://www.yso.fi/onto/yso/p29640
jyx.subject.urihttp://www.yso.fi/onto/yso/p1749
jyx.subject.urihttp://www.yso.fi/onto/yso/p27720
jyx.subject.urihttp://www.yso.fi/onto/yso/p8278
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.datasethttps://doi.org/10.5061/dryad.10gk660
dc.relation.doi10.1128/mSystems.00104-18
dc.relation.funderSuomen Akatemiafi
dc.relation.funderResearch Council of Finlanden
jyx.fundingprogramAkatemiatutkija, SAfi
jyx.fundingprogramAcademy Research Fellow, AoFen
jyx.fundinginformationThis work was supported by an Academy of Finland grant (no. 106993) and a University of Helsinki grant (no. 490152) to T.H.; by a Finnish Cultural Foundation grant (no. 160149) and by University of Helsinki Doctoral Programme in Microbiology and Biotechnology funding to J.C.; and by Academy of Finland grants (no. 252411 and no. 297049) and a Emil Aaltonen Foundation grant to M.J.
dc.type.okmA1


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