Autophagy is induced by resistance exercise in young men but unfolded protein response is induced regardless of age
Hentilä, J., Ahtiainen, J., Paulsen, G., Raastad, T., Häkkinen, K., Mero, A., & Hulmi, J. (2018). Autophagy is induced by resistance exercise in young men but unfolded protein response is induced regardless of age. Acta Physiologica, 224(1), Article e13069. https://doi.org/10.1111/apha.13069
Julkaistu sarjassa
Acta PhysiologicaTekijät
Päivämäärä
2018Oppiaine
LiikuntafysiologiaValmennus- ja testausoppiExercise PhysiologyScience of Sport Coaching and Fitness TestingTekijänoikeudet
© 2018 Scandinavian Physiological Society.
Aim
Autophagy and unfolded protein response (UPR) appear to be important for skeletal muscle homoeostasis and may be altered by exercise. Our aim was to investigate the effects of resistance exercise and training on indicators of UPR and autophagy in healthy untrained young men (n = 12, 27 ± 4 years) and older men (n = 8, 61 ± 6 years) as well as in resistance‐trained individuals (n = 15, 25 ± 5 years).
Methods
Indicators of autophagy and UPR were investigated from the muscle biopsies after a single resistance exercise bout and after 21 weeks of resistance training.
Results
Lipidated LC3II as an indicator of autophagosome content increased at 48 hours post‐resistance exercise (P < .05) and after a resistance training period (P < .01) in untrained young men but not in older men. Several UPRER markers, typically induced by protein misfolding in endoplasmic reticulum, were increased at 48 hours post‐resistance exercise in untrained young and older men (P < .05) but were unaltered after the 21‐week resistance training period regardless of age. UPR was unchanged within the first few hours after the resistance exercise bout regardless of the training status. Changes in autophagy and UPRER indicators did not correlate with a resistance training‐induced increase in muscle strength and size.
Conclusion
Autophagosome content is increased by resistance training in young previously untrained men, but this response may be blunted by ageing. However, unfolded protein response is induced by an unaccustomed resistance exercise bout in a delayed manner regardless of age.
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Julkaisija
Wiley-Blackwell Publishing Ltd.ISSN Hae Julkaisufoorumista
1748-1708Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/27984132
Metadata
Näytä kaikki kuvailutiedotKokoelmat
- Liikuntatieteiden tiedekunta [3032]
Rahoittaja(t)
Suomen AkatemiaRahoitusohjelmat(t)
Akatemiatutkija, SALisätietoja rahoituksesta
The Finnish Ministry of Education (to AAM), Academy of Finland (grant No. 275922 to JJH) and Finnish Cultural Foundation (JH personal grant) supported this research.Lisenssi
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