Dynamic DNA Origami Devices : from Strand-Displacement Reactions to External-Stimuli Responsive Systems
Ijäs, H., Nummelin, S., Shen, B., Kostiainen, M. A., & Linko, V. (2018). Dynamic DNA Origami Devices : from Strand-Displacement Reactions to External-Stimuli Responsive Systems. International Journal of Molecular Sciences, 19(7), Article 2114. https://doi.org/10.3390/ijms19072114
Published inInternational Journal of Molecular Sciences
© the Authors, 2018.
DNA nanotechnology provides an excellent foundation for diverse nanoscale structures that can be used in various bioapplications and materials research. Among all existing DNA assembly techniques, DNA origami proves to be the most robust one for creating custom nanoshapes. Since its invention in 2006, building from the bottom up using DNA advanced drastically, and therefore, more and more complex DNA-based systems became accessible. So far, the vast majority of the demonstrated DNA origami frameworks are static by nature; however, there also exist dynamic DNA origami devices that are increasingly coming into view. In this review, we discuss DNA origami nanostructures that exhibit controlled translational or rotational movement when triggered by predefined DNA sequences, various molecular interactions, and/or external stimuli such as light, pH, temperature, and electromagnetic fields. The rapid evolution of such dynamic DNA origami tools will undoubtedly have a significant impact on molecular-scale precision measurements, targeted drug delivery and diagnostics; however, they can also play a role in the development of optical/plasmonic sensors, nanophotonic devices, and nanorobotics for numerous different tasks. ...
ISSN Search the Publication Forum1661-6596
Publication in research information system
MetadataShow full item record
Showing items with similar title or keywords.
DNA-based applications in molecular electronics Linko, Veikko (University of Jyväskylä, 2011)This thesis is mainly focused on DNA molecules and especially on self-assembled DNA constructs and their potential applications in nanotechnology and molecular electronics. In the field of molecular electronics the ...
DNA-Based Enzyme Reactors and Systems Linko, Veikko; Nummelin, Sami; Aarnos, Laura; Tapio, Kosti; Toppari, Jussi; Kostiainen, Mauri A. (MDPI AG, 2016)During recent years, the possibility to create custom biocompatible nanoshapes using DNA as a building material has rapidly emerged. Further, these rationally designed DNA structures could be exploited in positioning ...
Constructing Large 2D Lattices Out of DNA-Tiles Parikka, Johannes M.; Sokołowska, Karolina; Markešević, Nemanja; Toppari, J. J. (MDPI, 2021)The predictable nature of deoxyribonucleic acid (DNA) interactions enables assembly of DNA into almost any arbitrary shape with programmable features of nanometer precision. The recent progress of DNA nanotechnology has ...
DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications Piskunen, Petteri; Shen, Boxuan; Julin, Sofia; Ijäs, Heini; Toppari, Jussi J.; Kostiainen, Mauri A.; Linko, Veikko (MyJove Corp., 2019)Structural DNA nanotechnology provides a viable route for building from the bottom-up using DNA as construction material. The most common DNA nanofabrication technique is called DNA origami, and it allows high-throughput ...
Metallic Nanostructures Based on DNA Nanoshapes Shen, Boxuan; Tapio, Kosti; Linko, Veikko; Kostiainen, Mauri A.; Toppari, Jussi (MDPI AG, 2016)Metallic nanostructures have inspired extensive research over several decades, particularly within the field of nanoelectronics and increasingly in plasmonics. Due to the limitations of conventional lithography methods, ...