Dynamic DNA Origami Devices : from Strand-Displacement Reactions to External-Stimuli Responsive Systems
Ijäs, H., Nummelin, S., Shen, B., Kostiainen, M. A., & Linko, V. (2018). Dynamic DNA Origami Devices : from Strand-Displacement Reactions to External-Stimuli Responsive Systems. International Journal of Molecular Sciences, 19(7), Article 2114. https://doi.org/10.3390/ijms19072114
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2018Copyright
© the Authors, 2018.
DNA nanotechnology provides an excellent foundation for diverse nanoscale structures
that can be used in various bioapplications and materials research. Among all existing DNA assembly
techniques, DNA origami proves to be the most robust one for creating custom nanoshapes. Since its
invention in 2006, building from the bottom up using DNA advanced drastically, and therefore,
more and more complex DNA-based systems became accessible. So far, the vast majority of the
demonstrated DNA origami frameworks are static by nature; however, there also exist dynamic
DNA origami devices that are increasingly coming into view. In this review, we discuss DNA
origami nanostructures that exhibit controlled translational or rotational movement when triggered
by predefined DNA sequences, various molecular interactions, and/or external stimuli such as light,
pH, temperature, and electromagnetic fields. The rapid evolution of such dynamic DNA origami tools
will undoubtedly have a significant impact on molecular-scale precision measurements, targeted drug
delivery and diagnostics; however, they can also play a role in the development of optical/plasmonic
sensors, nanophotonic devices, and nanorobotics for numerous different tasks.
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